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A surge in academic publications calls for automated deep research (DR) systems, but accurately evaluating them is still an open problem. First, existing benchmarks often focus narrowly on retrieval while neglecting high-level planning and…

Computation and Language · Computer Science 2026-02-02 Zhihan Guo , Feiyang Xu , Yifan Li , Muzhi Li , Shuai Zou , Jiele Wu , Han Shi , Haoli Bai , Ho-fung Leung , Irwin King

Objective: Question answering (QA) systems have the potential to improve the quality of clinical care by providing health professionals with the latest and most relevant evidence. However, QA systems have not been widely adopted. This…

Computation and Language · Computer Science 2024-02-06 Gregory Kell , Angus Roberts , Serge Umansky , Linglong Qian , Davide Ferrari , Frank Soboczenski , Byron Wallace , Nikhil Patel , Iain J Marshall

As artificial intelligence (AI) becomes increasingly embedded in healthcare delivery, this chapter explores the critical aspects of developing reliable and ethical Clinical Decision Support Systems (CDSS). Beginning with the fundamental…

Artificial Intelligence · Computer Science 2025-02-18 Muhammet Alkan , Idris Zakariyya , Samuel Leighton , Kaushik Bhargav Sivangi , Christos Anagnostopoulos , Fani Deligianni

This paper introduces BioAgent Bench, a benchmark dataset and an evaluation suite designed for measuring the performance and robustness of AI agents in common bioinformatics tasks. The benchmark contains curated end-to-end tasks (e.g.,…

Artificial Intelligence · Computer Science 2026-05-08 Dionizije Fa , Marko Culjak , Bruno Pandza , Mateo Cupic

Diagnostic errors in healthcare persist as a critical challenge, with increasing numbers of patients turning to online resources for health information. While AI-powered healthcare chatbots show promise, there exists no standardized and…

Artificial Intelligence · Computer Science 2024-12-18 Deep Bhatt , Surya Ayyagari , Anuruddh Mishra

Advancing the state-of-the-art in large-scale biomedical semantic indexing and question answering is the main focus of the BioASQ challenge. BioASQ organizes respective tasks where different teams develop systems that are evaluated on the…

Users across enterprises increasingly rely on AI agents to query their data through natural language. However, building reliable data agents remains difficult because real-world data is often fragmented across multiple heterogeneous…

In the era of data-driven decision-making, the complexity of data analysis necessitates advanced expertise and tools of data science, presenting significant challenges even for specialists. Large Language Models (LLMs) have emerged as…

Artificial Intelligence · Computer Science 2024-02-28 Yuge Zhang , Qiyang Jiang , Xingyu Han , Nan Chen , Yuqing Yang , Kan Ren

Benchmarking competitions are central to the development of artificial intelligence (AI) in medical imaging, defining performance standards and shaping methodological progress. However, it remains unclear whether these benchmarks provide…

Motivation: Many researchers with domain expertise are unable to easily apply machine learning to their bioinformatics data due to a lack of machine learning and/or coding expertise. Methods that have been proposed thus far to automate…

Machine Learning · Computer Science 2020-04-29 William La Cava , Heather Williams , Weixuan Fu , Steve Vitale , Durga Srivatsan , Jason H. Moore

We envision the Full-Body AI Agent as a comprehensive AI system designed to simulate, analyze, and optimize the dynamic processes of the human body across multiple biological levels. By integrating computational models, machine learning…

Tissues and Organs · Quantitative Biology 2025-08-28 Aoqi Wang , Jiajia Liu , Jianguo Wen , Yangyang Luo , Zhiwei Fan , Liren Yang , Xi Hu , Ruihan Luo , Yankai Yu , Sophia Li , Weiling Zhao , Xiaobo Zhou

Artificial intelligence (AI) systems have the potential to revolutionize clinical practices, including improving diagnostic accuracy and surgical decision-making, while also reducing costs and manpower. However, it is important to recognize…

Artificial Intelligence · Computer Science 2024-09-18 Yifan Yang , Mingquan Lin , Han Zhao , Yifan Peng , Furong Huang , Zhiyong Lu

A growing body of work pursues AI scientists capable of end-to-end autonomous scientific discovery. This position paper argues that although they already function as co-scientists, agentic AI scientists are not built for autonomous…

Artificial Intelligence · Computer Science 2026-05-12 Harshit Bisht , Vinay Kumar , Kevin Maik Jablonka , Mausam , N. M. Anoop Krishnan

Critical appraisal of scientific literature is an essential skill in the biomedical field. While large language models (LLMs) can offer promising support in this task, their reliability remains limited, particularly for critical reasoning…

Computation and Language · Computer Science 2026-03-05 Doria Bonzi , Alexandre Guiggi , Frédéric Béchet , Carlos Ramisch , Benoit Favre

Verification of biomedical claims is critical for healthcare decision-making, public health policy and scientific research. We present an interactive biomedical claim verification system by integrating LLMs, transparent model explanations,…

Human-Computer Interaction · Computer Science 2025-03-03 Siting Liang , Daniel Sonntag

The rapid growth of biomedical data, tools, and literature has created a fragmented research landscape that outpaces human expertise. While AI agents offer a solution, they typically rely on static, manually curated toolsets, limiting their…

Artificial Intelligence · Computer Science 2025-07-04 Ruofan Jin , Zaixi Zhang , Mengdi Wang , Le Cong

Large Language Models (LLMs) show promise as data analysis agents, but existing benchmarks overlook the iterative nature of the field, where experts' decisions evolve with deeper insights of the dataset. To address this, we introduce…

Computation and Language · Computer Science 2025-06-09 Hanyu Li , Haoyu Liu , Tingyu Zhu , Tianyu Guo , Zeyu Zheng , Xiaotie Deng , Michael I. Jordan

Agentic AI scientists equipped with domain-specific tools are rapidly entering scientific workflows across disciplines, with especially strong uptake in the life sciences where they can be used for literature synthesis, sequence analysis,…

Other Quantitative Biology · Quantitative Biology 2026-05-05 Kimon Antonios Provatas , Avery Self , Ioannis Mouratidis , Ilias Georgakopoulos-Soares

Engineered image-based biomarkers offer a clinically interpretable alternative to black-box AI in computational pathology, yet their discovery remains largely intuition-driven, guided by fragmented literature rather than rigorous biological…

Can AI systems trained on the scientific record up to a fixed point in time forecast the scientific advances that follow? Such a capability could help researchers identify collaborators and impactful research directions, and anticipate…

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