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Synthetic DNA approaches 227.5 exabytes per gram of storage density with stability over millennial timescales. Realising this capacity requires error-correction codes that recover data from substantial synthesis and sequencing errors.…

Information Theory · Computer Science 2026-04-23 James L. Banal

Large pools of synthetic DNA molecules have been recently used to reliably store significant volumes of digital data. While DNA as a storage medium has enormous potential because of its high storage density, its practical use is currently…

Data Structures and Algorithms · Computer Science 2021-02-25 Konstantin Makarychev , Miklos Z. Racz , Cyrus Rashtchian , Sergey Yekhanin

DNA is a promising storage medium, but its stability and occurrence of Indel errors pose a significant challenge. The relative occurrence of Guanine(G) and Cytosine(C) in DNA is crucial for its longevity, and reverse complementary base…

Information Theory · Computer Science 2024-01-15 NallappaBhavithran G , Selvakumar R

Deep image compression performs better than conventional codecs, such as JPEG, on natural images. However, deep image compression is learning-based and encounters a problem: the compression performance deteriorates significantly for…

Image and Video Processing · Electrical Eng. & Systems 2022-11-03 Koki Tsubota , Hiroaki Akutsu , Kiyoharu Aizawa

In this paper, we study the Random Access Problem in DNA storage, which addresses the challenge of retrieving a specific information strand from a DNA-based storage system. In this framework, the data is represented by $k$ information…

Information Theory · Computer Science 2025-08-26 Avital Boruchovsky , Ohad Elishco , Ryan Gabrys , Anina Gruica , Itzhak Tamo , Eitan Yaakobi

As the global need for large-scale data storage is rising exponentially, existing storage technologies are approaching their theoretical and functional limits in terms of density and energy consumption, making DNA based storage a potential…

Emerging Technologies · Computer Science 2021-10-12 Yotam Nahum , Eyar Ben-Tolila , Leon Anavy

The DNA storage channel is considered, in which a codeword is comprised of $M$ unordered DNA molecules. At reading time, $N$ molecules are sampled with replacement, and then each molecule is sequenced. A coded-index concatenated-coding…

Information Theory · Computer Science 2022-05-23 Nir Weinberger

Recent genomic foundation models largely adopt large language model architectures that treat DNA as a one-dimensional token sequence. However, exhaustive sequential reading is structurally misaligned with sparse and discontinuous genomic…

Computer Vision and Pattern Recognition · Computer Science 2026-02-03 Hongxin Xiang , Pengsen Ma , Yunkang Cao , Di Yu , Haowen Chen , Xinyu Yang , Xiangxiang Zeng

Compression is a crucial solution for data reduction in modern scientific applications due to the exponential growth of data from simulations, experiments, and observations. Compression with progressive retrieval capability allows users to…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-04-08 Zhuoxun Yang , Sheng Di , Longtao Zhang , Ruoyu Li , Ximiao Li , Jiajun Huang , Jinyang Liu , Franck Cappello , Kai Zhao

Lossless image compression is an important technique for image storage and transmission when information loss is not allowed. With the fast development of deep learning techniques, deep neural networks have been used in this field to…

Image and Video Processing · Electrical Eng. & Systems 2021-08-25 Honglei Zhang , Francesco Cricri , Hamed R. Tavakoli , Nannan Zou , Emre Aksu , Miska M. Hannuksela

In this paper, we study achievable rates of concatenated coding schemes over a deoxyribonucleic acid (DNA) storage channel. Our channel model incorporates the main features of DNA-based data storage. First, information is stored on many,…

Information Theory · Computer Science 2020-05-04 Andreas Lenz , Lorenz Welter , Sven Puchinger

With the advancement in technology, digital images can easily be transmitted and stored over the Internet. Encryption is used to avoid illegal interception of digital images. Encrypting large-sized colour images in their original dimension…

Image compression and reconstruction are crucial for various digital applications. While contemporary neural compression methods achieve impressive compression rates, the adoption of such technology has been largely hindered by the…

Machine Learning · Computer Science 2025-10-06 Ethan G. Rogers , Cheng Wang

Motivation: High-coverage sequencing data have significant, yet hard to exploit, redundancy. Most FASTQ compressors cannot efficiently compress the DNA stream of large datasets, since the redundancy between overlapping reads cannot be…

Data Structures and Algorithms · Computer Science 2014-09-19 Szymon Grabowski , Sebastian Deorowicz , Łukasz Roguski

With limited storage/bandwidth resources, input images to Computer Vision (CV) applications that use Deep Neural Networks (DNNs) are often encoded with JPEG that is tailored to Human Vision (HV). This paper presents Deep Selector-JPEG, an…

Image and Video Processing · Electrical Eng. & Systems 2023-02-21 Hossam Amer , Sepideh Shaterian , En-hui Yang

In many ultrasonic imaging systems, data acquisition and image formation are performed on separate computing devices. Data transmission is becoming a bottleneck, thus, efficient data compression is essential. Compression rates can be…

Image and Video Processing · Electrical Eng. & Systems 2021-09-02 Georgios Pilikos , Lars Horchens , Kees Joost Batenburg , Tristan van Leeuwen , Felix Lucka

We investigate the fundamental limits of the recently proposed random access coverage depth problem for DNA data storage. Under this paradigm, it is assumed that the user information consists of $k$ information strands, which are encoded…

Information Theory · Computer Science 2025-09-25 Anina Gruica , Daniella Bar-Lev , Alberto Ravagnani , Eitan Yaakobi

Data storage in DNA is developing as a possible solution for archival digital data. Recently, to further increase the potential capacity of DNA-based data storage systems, the combinatorial composite DNA synthesis method was suggested. This…

Information Theory · Computer Science 2024-05-28 Omer Sabary , Inbal Preuss , Ryan Gabrys , Zohar Yakhini , Leon Anavy , Eitan Yaakobi

Relative compression, where a set of similar strings are compressed with respect to a reference string, is a very effective method of compressing DNA datasets containing multiple similar sequences. Relative compression is fast to perform…

Quantitative Methods · Quantitative Biology 2011-06-21 Shanika Kuruppu , Simon Puglisi , Justin Zobel

Compressed indexing is a powerful technique that enables efficient querying over data stored in compressed form, significantly reducing memory usage and often accelerating computation. While extensive progress has been made for…

Data Structures and Algorithms · Computer Science 2025-10-23 Rajat De , Dominik Kempa