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In principle, deep learning models trained on medical time-series, including wearable photoplethysmography (PPG) sensor data, can provide a means to continuously monitor physiological parameters outside of clinical settings. However, there…

Uncertainty quantification (UQ) is critical for safety-critical domains like healthcare, yet it is rarely evaluated under realistic out-of-distribution (OOD) conditions. Here, we assessed predictive performance and uncertainty reliability…

Machine Learning · Computer Science 2026-05-19 Mohammad Moulaeifard , Ciaran Bench , Philip J. Aston , Nils Strodthoff

In principle, deep generative models can be used to perform domain adaptation; i.e. align the input feature representations of test data with that of a separate discriminative model's training data. This can help improve the discriminative…

Machine Learning · Computer Science 2026-04-21 Ciaran Bench

Photoplethysmography (PPG) is a non-invasive technology that measures changes in blood volume in the microvascular bed of tissue. It is commonly used in medical devices such as pulse oximeters and wrist worn heart rate monitors to monitor…

Remote photoplethysmography (rPPG) technology infers heart rate by capturing subtle color changes in facial skin using a camera, demonstrating great potential in non-contact heart rate measurement. However, measurement accuracy…

Machine Learning · Computer Science 2025-04-08 Rufei Ma , Chao Chen

Data-driven forecasts of air quality have recently achieved more accurate short-term predictions. Despite their success, most of the current data-driven solutions lack proper quantifications of model uncertainty that communicate how much to…

Machine Learning · Computer Science 2021-12-07 Abdulmajid Murad , Frank Alexander Kraemer , Kerstin Bach , Gavin Taylor

Photoplethysmography (PPG)-based blood pressure (BP) estimation is a challenging task, particularly on resource-constrained wearable devices. However, fully on-board processing is desirable to ensure user data confidentiality. Recent deep…

Deep neural networks (DNNs) have become integral to a wide range of scientific and practical applications due to their flexibility and strong predictive performance. Despite their accuracy, however, DNNs frequently exhibit poor calibration,…

Machine Learning · Computer Science 2026-03-12 Sanne Ruijs , Alina Kosiakova , Farrukh Javed

Background and objective: Uncertainty quantification is a pivotal field that contributes to realizing reliable and robust systems. It becomes instrumental in fortifying safe decisions by providing complementary information, particularly…

Image and Video Processing · Electrical Eng. & Systems 2024-03-19 Jamil Fayyad , Shadi Alijani , Homayoun Najjaran

Cardiac abnormalities affecting heart rate and rhythm are commonly observed in both healthy and acutely unwell people. Although many of these are benign, they can sometimes indicate a serious health risk. ECG monitors are typically used to…

Signal Processing · Electrical Eng. & Systems 2018-07-12 Stewart Whiting , Samuel Moreland , Jason Costello , Glen Colopy , Christopher McCann

The use of observed wearable sensor data (e.g., photoplethysmograms [PPG]) to infer health measures (e.g., glucose level or blood pressure) is a very active area of research. Such technology can have a significant impact on health…

Signal Processing · Electrical Eng. & Systems 2023-05-01 Suril Mehta , Nipun Kwatra , Mohit Jain , Daniel McDuff

Photoplethysmography (PPG) is a widely used non-invasive physiological sensing technique, suitable for various clinical applications. Such clinical applications are increasingly supported by machine learning methods, raising the question of…

We evaluate two different methods for the integration of prediction uncertainty into diagnostic image classifiers to increase patient safety in deep learning. In the first method, Monte Carlo sampling is applied with dropout at test time to…

Image and Video Processing · Electrical Eng. & Systems 2019-08-05 Max-Heinrich Laves , Sontje Ihler , Tobias Ortmaier

Photoplethysmography (PPG) is one of the most widely captured biosignals for clinical prediction tasks, yet PPG-based algorithms are typically trained on small-scale datasets of uncertain quality, which hinders meaningful algorithm…

Machine Learning · Computer Science 2026-03-24 Mohammad Moulaeifard , Philip J. Aston , Peter H. Charlton , Nils Strodthoff

Exploiting photoplethysmography signals (PPG) for non-invasive blood pressure (BP) measurement is interesting for various reasons. First, PPG can easily be measured using fingerclip sensors. Second, camera-based approaches allow to derive…

Machine Learning · Computer Science 2021-04-20 Fabian Schrumpf , Patrick Frenzel , Christoph Aust , Georg Osterhoff , Mirco Fuchs

Uncertainty quantification in automated image analysis is highly desired in many applications. Typically, machine learning models in classification or segmentation are only developed to provide binary answers; however, quantifying the…

Heart rate estimation from photoplethysmography (PPG) signals generated by wearable devices such as smartwatches and fitness trackers has significant implications for the health and well-being of individuals. Although prior work has…

Machine Learning · Computer Science 2025-12-10 Kanav Arora , Girish Narayanswamy , Shwetak Patel , Richard Li

Precise estimation of predictive uncertainty in deep neural networks is a critical requirement for reliable decision-making in machine learning and statistical modeling, particularly in the context of medical AI. Conformal Prediction (CP)…

Machine Learning · Computer Science 2024-01-05 Hamed Karimi , Reza Samavi

Analyzing the cardiovascular system condition via Electrocardiography (ECG) is a common and highly effective approach, and it has been practiced and perfected over many decades. ECG sensing is non-invasive and relatively easy to acquire,…

Mathematical models are essential tools to study how the cardiovascular system maintains homeostasis. The utility of such models is limited by the accuracy of their predictions, which can be determined by uncertainty quantification (UQ). A…

Quantitative Methods · Quantitative Biology 2018-07-20 Andrew D. Marquis , Andrea Arnold , Caron Dean , Brian E. Carlson , Mette S. Olufsen
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