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In the past decades, recommender systems have attracted much attention in both research and industry communities, and a large number of studies have been devoted to developing effective recommendation models. Basically speaking, these…

Information Retrieval · Computer Science 2023-05-12 Junjie Zhang , Ruobing Xie , Yupeng Hou , Wayne Xin Zhao , Leyu Lin , Ji-Rong Wen

Accurate prediction of clinical outcomes using Electronic Health Records (EHRs) is critical for early intervention, efficient resource allocation, and improved patient care. EHRs contain multimodal data, including both structured data and…

Machine Learning · Computer Science 2025-08-29 Rituparna Datta , Jiaming Cui , Zihan Guan , Vishal G. Reddy , Joshua C. Eby , Gregory Madden , Rupesh Silwal , Anil Vullikanti

Objective: Large language models (LLMs) are attracting increasing interest in healthcare. This commentary evaluates the potential of LLMs to improve clinical prediction models (CPMs) for diagnostic and prognostic tasks, with a focus on…

Computers and Society · Computer Science 2025-11-07 Yusuf Yildiz , Goran Nenadic , Meghna Jani , David A. Jenkins

Large language models (LLMs) have achieved remarkable progress in the field of natural language processing (NLP), demonstrating remarkable abilities in producing text that resembles human language for various tasks. This opens up new…

Information Retrieval · Computer Science 2024-06-05 Jianghao Lin , Xinyi Dai , Rong Shan , Bo Chen , Ruiming Tang , Yong Yu , Weinan Zhang

Although large language models (LLMs) demonstrate expert-level medical knowledge, aligning their open-ended outputs with fine-grained clinician preferences remains challenging. Existing methods often rely on coarse objectives or unreliable…

Artificial Intelligence · Computer Science 2026-02-12 Shiwei Lyu , Xidong Wang , Lei Liu , Hao Zhu , Chaohe Zhang , Jian Wang , Jinjie Gu , Benyou Wang , Yue Shen

Clinical trials provide essential guidance for practicing Evidence-Based Medicine, though often accompanying with unendurable costs and risks. To optimize the design of clinical trials, we introduce a novel Clinical Trial Result Prediction…

Computation and Language · Computer Science 2020-10-13 Qiao Jin , Chuanqi Tan , Mosha Chen , Xiaozhong Liu , Songfang Huang

Large language models (LLMs), including zero-shot and few-shot paradigms, have shown promising capabilities in clinical text generation. However, real-world applications face two key challenges: (1) patient data is highly unstructured,…

Computation and Language · Computer Science 2025-07-10 Garapati Keerthana , Manik Gupta

Biomedical question answering often requires decisions from retrieved literature whose relevance, quality, and support for candidate answers are uneven. Most retrieval-augmented large language model (LLM) methods feed this literature to the…

Computation and Language · Computer Science 2026-05-19 Chang Zong , Hao Ning , Siliang Tang , Jie Huang , Jian Wan

Large language models (LLMs) have shown great promise in the medical domain, achieving strong performance on several benchmarks. However, they continue to underperform in real-world medical scenarios, which often demand stronger…

Artificial Intelligence · Computer Science 2025-11-17 Yuxuan Zhou , Yubin Wang , Bin Wang , Chen Ning , Xien Liu , Ji Wu , Jianye Hao

Clinical practice guidelines (CPGs) provide evidence-based recommendations for patient care; however, integrating them into Artificial Intelligence (AI) remains challenging. Previous approaches, such as rule-based systems, face significant…

Artificial Intelligence · Computer Science 2026-01-08 Ruiqi Deng , Geoffrey Martin , Tony Wang , Gongbo Zhang , Yi Liu , Chunhua Weng , Yanshan Wang , Justin F Rousseau , Yifan Peng

The inherent complexity of structured longitudinal Electronic Health Records (EHR) data poses a significant challenge when integrated with Large Language Models (LLMs), which are traditionally tailored for natural language processing.…

Computation and Language · Computer Science 2024-02-13 Yinghao Zhu , Zixiang Wang , Junyi Gao , Yuning Tong , Jingkun An , Weibin Liao , Ewen M. Harrison , Liantao Ma , Chengwei Pan

Large Language Models (LLMs) have demonstrated promise in medical knowledge assessments, yet their practical utility in real-world clinical decision-making remains underexplored. In this study, we evaluated the performance of three…

Computation and Language · Computer Science 2025-12-30 Mengdi Chai , Ali R. Zomorrodi

Longitudinal information in radiology reports refers to the sequential tracking of findings across multiple examinations over time, which is crucial for monitoring disease progression and guiding clinical decisions. Many recent automated…

Computation and Language · Computer Science 2026-01-26 Xinyi Wang , Grazziela Figueredo , Ruizhe Li , Xin Chen

Systems that collect data on sleep, mood, and activities can provide valuable lifestyle counselling to populations affected by chronic disease and its consequences. Such systems are, however, challenging to develop; besides reliably…

Computation and Language · Computer Science 2026-03-10 Yee Man Ng , Bram van Dijk , Pieter Beynen , Otto Boekesteijn , Joris Jansen , Gerard van Oortmerssen , Max van Duijn , Marco Spruit

Large Language Models (LLMs) have emerged as powerful tools for generating coherent text, understanding context, and performing reasoning tasks. However, they struggle with temporal reasoning, which requires processing time-related…

Machine Learning · Computer Science 2025-06-02 Adrián Bazaga , Rexhina Blloshmi , Bill Byrne , Adrià de Gispert

Decision-making is a cognitively intensive task that requires synthesizing relevant information from multiple unstructured sources, weighing competing factors, and incorporating subjective user preferences. Existing methods, including large…

Computation and Language · Computer Science 2026-04-21 Akriti Jain , Anish Mulay , Divyansh Verma , Aishani Pandey , Pritika Ramu , Aparna Garimella

To effect behavior change a successful algorithm must make high-quality decisions in real-time. For example, a mobile health (mHealth) application designed to increase physical activity must make contextually relevant suggestions to…

Machine Learning · Statistics 2020-03-31 Marianne Menictas , Sabina Tomkins , Susan A Murphy

Conversational and question-based recommender systems have gained increasing attention in recent years, with users enabled to converse with the system and better control recommendations. Nevertheless, research in the field is still limited,…

Information Retrieval · Computer Science 2020-06-01 Jie Zou , Yifan Chen , Evangelos Kanoulas

Large Language Models (LLMs) have emerged as a promising paradigm for next-generation recommender systems, offering strong semantic understanding and natural-language reasoning abilities. Despite recent progress, current LLM-based…

Information Retrieval · Computer Science 2026-05-11 Shijun Li , Wooseong Yang , Yu Wang , Tianxin Wei , Joydeep Ghosh

Medical Question Answering~(medical QA) systems play an essential role in assisting healthcare workers in finding answers to their questions. However, it is not sufficient to merely provide answers by medical QA systems because users might…

Computation and Language · Computer Science 2023-10-03 Wei Sun , Mingxiao Li , Damien Sileo , Jesse Davis , Marie-Francine Moens