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Clinical practice guidelines are long, multimodal documents whose branching recommendations are difficult to convert into executable clinical decision support (CDS), and one-shot parsing often breaks cross-page continuity. Recent LLM/VLM…

Computer Vision and Pattern Recognition · Computer Science 2026-04-06 Onur Selim Kilic , Yeti Z. Gurbuz , Cem O. Yaldiz , Afra Nawar , Etrit Haxholli , Ogul Can , Eli Waxman

With their growing capabilities, generative large language models (LLMs) are being increasingly investigated for complex medical tasks. However, their effectiveness in real-world clinical applications remains underexplored. To address this,…

Computation and Language · Computer Science 2026-01-27 Paul Grundmann , Dennis Fast , Jan Frick , Thomas Steffek , Felix Gers , Wolfgang Nejdl , Alexander Löser

As real-world datasets become more complex and heterogeneous, supervised learning is often bottlenecked by input representation design. Modeling multimodal data, such as time-series, free text, and structured records, often requires…

Artificial Intelligence · Computer Science 2026-05-22 Ilker Demirel , Lawrence Shi , Zeshan Hussain , David Sontag

Existing LLM-based medical question-answering systems lack citation generation and evaluation capabilities, raising concerns about their adoption in practice. In this work, we introduce \name, the first end-to-end framework that facilitates…

Computation and Language · Computer Science 2025-06-10 Xiao Wang , Mengjue Tan , Qiao Jin , Guangzhi Xiong , Yu Hu , Aidong Zhang , Zhiyong Lu , Minjia Zhang

High-performing medical Large Language Models (LLMs) typically require extensive fine-tuning with substantial computational resources, limiting accessibility for resource-constrained healthcare institutions. This study introduces a…

Computation and Language · Computer Science 2025-10-17 Ziad Elshaer , Essam A. Rashed

Large language models (LLMs) show promise in automating clinical diagnosis, yet their non-transparent decision-making and limited alignment with diagnostic standards hinder trust and clinical adoption. We address this challenge by proposing…

Artificial Intelligence · Computer Science 2025-11-25 Yining Yuan , J. Ben Tamo , Micky C. Nnamdi , Yifei Wang , May D. Wang

Large Language Models (LLMs) have exhibited remarkable capabilities in clinical scenarios. Despite their potential, existing works face challenges when applying LLMs to medical settings. Strategies relying on training with medical datasets…

Computation and Language · Computer Science 2025-10-10 Keer Lu , Zheng Liang , Da Pan , Shusen Zhang , Guosheng Dong , Zhonghai Wu , Huang Leng , Bin Cui , Wentao Zhang

Evidence-based medicine, the practice in which healthcare professionals refer to the best available evidence when making decisions, forms the foundation of modern healthcare. However, it relies on labour-intensive systematic reviews, where…

Computation and Language · Computer Science 2021-12-13 Jetsun Whitton , Anthony Hunter

Patients have distinct information needs about their hospitalization that can be addressed using clinical evidence from electronic health records (EHRs). While artificial intelligence (AI) systems show promise in meeting these needs, robust…

Computation and Language · Computer Science 2026-03-31 Sarvesh Soni , Dina Demner-Fushman

Recent advances in large language models (LLMs) have enabled promising progress in diagnosis prediction from electronic health records (EHRs). However, existing LLM-based approaches tend to overfit to historically observed diagnoses, often…

Computation and Language · Computer Science 2026-04-14 Hengyu Zhang , Xuyun Zhang , Pengxiang Zhan , Linhao Luo , Hang Lv , Yanchao Tan , Shirui Pan , Carl Yang

The rapid advancement of large language models (LLMs) has opened new boundaries in the extraction and synthesis of medical knowledge, particularly within evidence synthesis. This paper reviews the state-of-the-art applications of LLMs in…

Large Language Models (LLMs), particularly smaller variants, still struggle with complex reasoning tasks. While inference-time prompting can guide reasoning, existing methods often rely on sequential queries. Ensemble approaches offer a…

Computation and Language · Computer Science 2025-10-28 Gregory Kang Ruey Lau , Wenyang Hu , Diwen Liu , Jizhuo Chen , See-Kiong Ng , Bryan Kian Hsiang Low

In recent years, knowledge graphs have been integrated into recommender systems as item-side auxiliary information, enhancing recommendation accuracy. However, constructing and integrating structural user-side knowledge remains a…

Information Retrieval · Computer Science 2024-12-19 Zheng Hu , Zhe Li , Ziyun Jiao , Satoshi Nakagawa , Jiawen Deng , Shimin Cai , Tao Zhou , Fuji Ren

The learning process for medical residents presents significant challenges, demanding both the ability to interpret complex case reports and the rapid acquisition of accurate medical knowledge from reliable sources. Residents typically…

Computation and Language · Computer Science 2026-02-03 Dongsuk Jang , Ziyao Shangguan , Kyle Tegtmeyer , Anurag Gupta , Jan Czerminski , Sophie Chheang , Arman Cohan

Transparent and standardized reporting is essential for reproducible scientific research, yet adherence to reporting guidelines remains inconsistent because of the manual effort required to select and complete checklists. We present…

Digital Libraries · Computer Science 2026-05-19 Satvik Tripathi , Don Enwerem , Kevin Song , Kristian Quevada , Jacinta Arnold , Tessa S. Cook

Despite advances in machine learning (ML) and large language models (LLMs), rule-based natural language processing (NLP) systems remain active in clinical settings due to their interpretability and operational efficiency. However, their…

Computation and Language · Computer Science 2025-06-23 Jianlin Shi , Brian T. Bucher

The growing use of large language models (LLMs) for biomedical question answering raises concerns about the accuracy and evidentiary support of their responses. To address this, we present Answered with Evidence, a framework for evaluating…

Machine Learning · Computer Science 2025-07-08 Julian D Baldwin , Christina Dinh , Arjun Mukerji , Neil Sanghavi , Saurabh Gombar

The National Comprehensive Cancer Network (NCCN) provides evidence-based guidelines for cancer treatment. Translating complex patient presentations into guideline-compliant treatment recommendations is time-intensive, requires specialized…

Requirements about the quality of clinical guidelines can be represented by schemata borrowed from the theory of abductive diagnosis, using temporal logic to model the time-oriented aspects expressed in a guideline. Previously, we have…

Artificial Intelligence · Computer Science 2008-12-18 Arjen Hommersom , Peter J. F. Lucas , Patrick van Bommel

Clinical documentation and data retrieval within Electronic Health Records (EHRs) contribute substantially to clinician workload and burnout. To address this, we developed Scout, an LLM-based EHR search and synthesis platform that enables…

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