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Cell-cell adhesion is one the most fundamental mechanisms regulating collective cell migration during tissue development, homeostasis and repair, allowing cell populations to self-organize and eventually form and maintain complex tissue…

Cell Behavior · Quantitative Biology 2022-11-16 Carles Falcó , Ruth E. Baker , José A. Carrillo

Non-local advection is a key process in a range of biological systems, from cells within individuals to the movement of whole organisms. Consequently, in recent years, there has been increasing attention on modelling non-local advection…

Analysis of PDEs · Mathematics 2021-06-14 Valeria Giunta , Thomas Hillen , Mark A. Lewis , Jonathan R. Potts

We study a nonlocal Cahn-Hilliard model for a multicomponent mixture with cross-diffusion effects and degenerate mobility. The nonlocality is described by means of a symmetric singular kernel. We define a notion of weak solution adapted to…

Analysis of PDEs · Mathematics 2026-05-22 Elisa Davoli , Greta Marino , Jan-Frederik Pietschmann

Motivated by recent work on approximation of diffusion equations by deterministic interacting particle systems, we develop a nonlocal approximation for a range of linear and nonlinear diffusion equations and prove convergence of the method…

Analysis of PDEs · Mathematics 2024-04-05 Katy Craig , Matt Jacobs , Olga Turanova

Biological aggregations such as insect swarms and bird flocks may arise from a combination of social interactions and environmental cues. We focus on nonlocal continuum equations, which are often used to model aggregations, and yet which…

Pattern Formation and Solitons · Physics 2016-05-16 Andrew J. Bernoff , Chad M. Topaz

Cell-cell adhesion is an inherently nonlocal phenomenon. Numerous partial differential equation models with nonlocal term have been recently presented to describe this phenomenon, yet the mathematical properties of nonlocal adhesion model…

Analysis of PDEs · Mathematics 2021-03-17 Jaewook Ahn , Myeongju Chae , Jihoon Lee

In this manuscript, we consider the modelling of cellular adhesions, which is a key interaction between biological cells. Continuum models of the diffusion-advection-reaction type have long been used in tissue modelling. In 2006, Armstrong,…

Analysis of PDEs · Mathematics 2020-01-03 Andreas Buttenschön , Thomas Hillen

The employment of nonlocal PDE models to describe biological aggregation and other phenomena has gained considerable traction in recent years. For cell populations, these methods grant a means of accommodating essential elements such as…

Quantitative Methods · Quantitative Biology 2024-12-10 Kevin J Painter , Thomas Hillen , Jonathan R Potts

We consider a nonlocal aggregation equation with nonlinear diffusion which arises from the study of biological aggregation dynamics. As a degenerate parabolic problem, we prove the well-posedness, continuation criteria and smoothness of…

Mathematical Physics · Physics 2009-02-13 Dong Li , Xiaoyi Zhang

Aggregation-diffusion equations are foundational tools for modelling biological aggregations. Their principal use is to link the collective movement mechanisms of organisms to their emergent space use patterns in a concrete mathematical…

Populations and Evolution · Quantitative Biology 2025-04-16 Jonathan R. Potts

Nonequilibrium thermodynamics has shown its applicability in a wide variety of different situations pertaining to fields such as physics, chemistry, biology, and engineering. As successful as it is, however, its current formulation…

Condensed Matter · Physics 2009-11-07 J. M. G. Vilar , J. M. Rubi

This paper reviews (and expands) some recent results on the modeling of aggregation-diffusion phenomena at various scales, focusing on the emergence of collective dynamics as a result of the competition between attractive and repulsive…

Analysis of PDEs · Mathematics 2024-01-04 Inwon Kim , Antoine Mellet , Jeremy Sheung-Him Wu

Diffusion is a fundamental physical phenomenon with critical applications in fields such as metallurgy, cell biology, and population dynamics. While standard diffusion is well-understood, anomalous diffusion often requires complex non-local…

Statistical Mechanics · Physics 2026-01-16 Gabriel Barreiro , Vladimir Pérez-Veloz

We explore analytically and numerically agglomeration driven by advection and localized source. The system is inhomogeneous in one dimension, viz. along the direction of advection. We analyze a simplified model with mass-independent…

There has been recently an important interest in deriving rigorously the Cahn-Hilliard equation from the nonlocal equation, also called aggregation equation. So far, only non-degenerate mobilities were treated. Since we are motivated by…

Analysis of PDEs · Mathematics 2022-12-19 Charles Elbar , Jakub Skrzeczkowski

In this paper, we study some qualitative properties for an evolution problem that combines local and nonlocal diffusion operators acting in two different subdomains and, coupled in such a way that, the resulting evolution problem is the…

Analysis of PDEs · Mathematics 2020-03-05 Bruna C. dos Santos , Sergio M. Oliva , Julio D. Rossi

We study problems in which a local model is coupled with a nonlocal one. We propose two energies: both of them are based on the same classical weighted $H^1$-semi norm to model the local part, while two different weighted $H^s$-semi norms,…

Numerical Analysis · Mathematics 2025-05-27 Juan Pablo Borthagaray , Patrick Ciarlet

This work concerns with a class of chemotaxis models in which external sources, comprising nonlocal and gradient-dependent damping reactions, influence the motion of a cell density attracted by a chemical signal. The mechanism of the two…

Analysis of PDEs · Mathematics 2024-06-17 Rafael Díaz Fuentes , Silvia Frassu , Giuseppe Viglialoro

We demonstrate how concepts of statistical mechanics of interacting particles can have important implications in the choice of interaction potentials to model qualitative properties of cell aggregates in theoretical biology. We illustrate…

Cell Behavior · Quantitative Biology 2017-06-29 J. A. Carrillo , A. Colombi , M. Scianna

Given a large ensemble of interacting particles, driven by nonlocal interactions and localized repulsion, the mean-field limit leads to a class of nonlocal, nonlinear partial differential equations known as aggregation-diffusion equations.…

Analysis of PDEs · Mathematics 2018-10-10 Jose A. Carrillo , Katy Craig , Yao Yao
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