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Probabilistic graphical models (PGMs) have become a popular tool for computational analysis of biological data in a variety of domains. But, what exactly are they and how do they work? How can we use PGMs to discover patterns that are…

Quantitative Methods · Quantitative Biology 2010-02-22 Edoardo M Airoldi

Establishing optimal cut-offs for clinical biomarkers is a fundamental statistical problem in epidemiology, clinical trials, and drug discovery. While there is extensive literature regarding the definition of optimal cut-offs for scalar…

Methodology · Statistics 2025-03-11 Oscar Lado-Baleato , Carla Díaz-Louza , Francisco Gude , Marcos Matabuena

Machine Learning (ML) algorithms are vital for supporting clinical decision-making in biomedical informatics. However, their predictive performance can vary across demographic groups, often due to the underrepresentation of historically…

Machine Learning · Computer Science 2025-03-04 Ioannis Bilionis , Ricardo C. Berrios , Luis Fernandez-Luque , Carlos Castillo

Food recognition and nutritional apps are trending technologies that may revolutionise the way people with diabetes manage their diet. Such apps can monitor food intake as a digital diary and even employ artificial intelligence to assess…

Computer Vision and Pattern Recognition · Computer Science 2024-10-14 Lubnaa Abdur Rahman , Ioannis Papathanail , Lorenzo Brigato , Elias K. Spanakis , Stavroula Mougiakakou

Objective: The design of an Artificial Pancreas (AP) to regulate blood glucose levels requires reliable control methods. Model Predictive Control has emerged as a promising approach for glycemia control. However, model--based control…

Optimization and Control · Mathematics 2022-02-02 Claudia Lopez-Zazueta , Øyvind Stavdahl , Anders Lyngvi Fougner

Effective diabetes management relies heavily on the continuous monitoring of blood glucose levels, traditionally achieved through invasive and uncomfortable methods. While various non-invasive techniques have been explored, such as optical,…

Machine Learning · Computer Science 2024-08-16 Nihat Ahmadli , Mehmet Ali Sarsil , Onur Ergen

Daytime hypoglycemia should be accurately predicted to achieve normoglycemia and to avoid disastrous situations. Hypoglycemia, an abnormally low blood glucose level, is divided into daytime hypoglycemia and nocturnal hypoglycemia. Many…

Machine Learning · Statistics 2017-05-01 Miyeon Jung , You-Bin Lee , Sang-Man Jin , Sung-Min Park

The availability of continuous glucose monitors as over-the-counter commodities have created a unique opportunity to monitor a person's blood glucose levels, forecast blood glucose trajectories and provide automated interventions to prevent…

Machine Learning · Computer Science 2026-04-16 Ebrahim Farahmand , Shovito Barua Soumma , Nooshin Taheri Chatrudi , Hassan Ghasemzadeh

Diabetes mellitus (DM) predisposes patients to vascular complications. Retinal images and vasculature reflect the body's micro- and macrovascular health. They can be used to diagnose DM complications, including diabetic retinopathy (DR),…

This study introduces a novel approach for early Type 2 Diabetes Mellitus (T2DM) risk prediction using a tabular transformer (TabTrans) architecture to analyze longitudinal patient data. By processing patients` longitudinal health records…

Computer Vision and Pattern Recognition · Computer Science 2026-01-21 Sulaiman Khan , Md. Rafiul Biswas , Zubair Shah

Type 1 diabetes (T1D) is an autoimmune disorder that leads to the destruction of insulin-producing cells, resulting in insulin deficiency, as to why the affected individuals depend on external insulin injections. However, insulin can…

Machine Learning · Computer Science 2026-04-27 Beyza Cinar , Maria Maleshkova

Objective: Create precise, structured, data-backed guidelines for type 2 diabetes treatment progression, suitable for clinical adoption. Research Design and Methods: Our training cohort was composed of patient (with type 2 diabetes) visits…

Artificial Intelligence · Computer Science 2025-04-18 Dewang Kumar Agarwal , Dimitris J. Bertsimas

Diabetes has a long asymptomatic period which can often remain undiagnosed for multiple years. In this study, we trained a deep learning model to detect new-onset diabetes using 12-lead ECG and readily available demographic information. To…

Machine Learning · Computer Science 2025-12-01 Hao Zhang , Neil Jethani , Aahlad Puli , Leonid Garber , Lior Jankelson , Yindalon Aphinyanaphongs , Rajesh Ranganath

Accurate forecasting of blood glucose from CGM is essential for preventing dysglycemic events, thus enabling proactive diabetes management. However, current forecasting models treat blood glucose readings captured using CGMs as a numerical…

Machine Learning · Computer Science 2026-01-12 Shovito Barua Soumma , Hassan Ghasemzadeh

Diabetes mellitus affects over 537 million adults worldwide and remains a major challenge in preventive healthcare. Existing machine-learning studies primarily formulate diabetes prediction as a binary classification problem, while…

Machine Learning · Computer Science 2026-05-14 Vishal Pandey , Ruzina Haque Laskar , Rishav Tewari

Standard objective functions used during the training of neural-network-based predictive models do not consider clinical criteria, leading to models that are not necessarily clinically acceptable. In this study, we look at this problem from…

Quantitative Methods · Quantitative Biology 2020-09-24 Maxime De Bois , Mounîm A. El Yacoubi , Mehdi Ammi

AI procedures joined with wearable gadgets can convey exact transient blood glucose level forecast models. Also, such models can learn customized glucose-insulin elements dependent on the sensor information gathered by observing a few parts…

Machine Learning · Computer Science 2021-01-22 Ignacio Rodriguez

Due to the sensitive nature of diabetes-related data, preventing them from being shared between studies, progress in the field of glucose prediction is hard to assess. To address this issue, we present GLYFE (GLYcemia Forecasting…

Signal Processing · Electrical Eng. & Systems 2020-06-30 Maxime De Bois , Mehdi Ammi , Mounîm A. El Yacoubi

We present and critically discuss five commonly used mathematical models of the meal glucose rate of appearance in humans. Such models are key to simulation of the metabolism in healthy people, people with diabetes, and obese people, and…

Systems and Control · Electrical Eng. & Systems 2023-08-01 Tobias K. S. Ritschel , Asbjørn Thode Reenberg , Peter Emil Carstensen , Jacob Bendsen , John Bagterp Jørgensen

Given their ability for advanced reasoning, extensive contextual understanding, and robust question-answering abilities, large language models have become prominent in healthcare management research. Despite adeptly handling a broad…

Artificial Intelligence · Computer Science 2025-01-15 Waqar Hussain , John Grundy
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