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Quantitative phase imaging (QPI) quantifies the sample-specific optical-phase-delay enabling objective studies of optically-transparent specimens such as biological samples, but lacks chemical sensitivity limiting its application to…

Optics · Physics 2019-09-04 Miu Tamamitsu , Keiichiro Toda , Ryoichi Horisaki , Takuro Ideguchi

Mid infrared (MIR) photonics is a key region for molecular physics [1]. High-resolution spectroscopy in the 1--10 {\mu}m region, though, has never been fully tackled for the lack of widely-tunable and practical light sources. Indeed, all…

Ovarian cancer detection has traditionally relied on a multi-step process that includes biopsy, tissue staining, and morphological analysis by experienced pathologists. While widely practiced, this conventional approach suffers from several…

Infrared (IR) imaging is invaluable across many scientific disciplines, from material analysis to diagnostic medicine. However, applications are often limited by detector cost, resolution and sensitivity, noise caused by the thermal IR…

Multispectral mid-infrared (2-5 ${{\mu}m}$) imaging is a critical capability across science and technology, offering a window into the vibrational and thermal landscape of matter that is inaccessible to visible sensors. It bridges the…

Optics · Physics 2026-01-29 Daniel Beitner , Ziv Abelson , Eyal Hollander , Omri Meron , Haim Suchowski

Quantum imaging with undetected photons (QIUP) is a unique method of image acquisition where the photons illuminating the object are not detected. This method relies on quantum interference and spatial correlations between the twin photons…

Quantum Physics · Physics 2024-07-29 Balakrishnan Viswanathan , Gabriela Barreto Lemos , Mayukh Lahiri

The emerging technique of mid-infrared optical coherence tomography (MIR-OCT) takes advantage of the reduced scattering of MIR light in various materials and devices, enabling tomographic imaging at deeper penetration depths. Because of…

Advancement in mid-infrared (MIR) technology has led to promising biomedical applications of MIR spectroscopy, such as liquid biopsy or breath diagnosis. On the contrary, MIR microscopy has been rarely used for live biological samples in an…

Frequency upconversion technique offers an appealing approach for sensitive mid-infrared (MIR) imaging at room temperature. However, the spatial resolution of the upconversion imager has been notoriously restricted by the limited transverse…

Chemical imaging based on mid-infrared (MIR) spectroscopic contrast is an important technique with a myriad of applications, including biomedical imaging and environmental monitoring. Current MIR cameras, however, lack in performance and…

Instrumentation and Detectors · Physics 2021-07-06 David Knez , Adam M. Hanninen , Richard C. Prince , Eric O. Potma , Dmitry A. Fishman

Atomic Force Microscopy - Infrared (AFM-IR) spectroscopy allows spectroscopic studies in the mid-infrared spectral region with a spatial resolution better than 50 nm. We show that the high spatial resolution can be used to perform…

Quantitative Methods · Quantitative Biology 2017-04-06 Luca Quaroni , Katarzyna Pogoda , Joanna-Wiltowska Zuber , Wojciech Kwiatek

Frequency up-conversion is an effective method of mid-infrared (MIR) detection by converting the long-wavelength photons to the visible domain, where efficient detectors are readily available. Here, we generate the MIR light carrying…

Single-photon laser ranging has widespread applications in remote sensing and target recognition. However, highly-sensitive light detection and ranging (LiDAR) has long been restricted in visible or near-infrared bands. An appealing quest…

Quantum illumination is a quantum-optical sensing technique in which an entangled source is exploited to improve the detection of a low-reflectivity object that is immersed in a bright thermal background. Here we describe and analyze a…

Mid-infrared photo-induced force microscopy (IR-PiFM/PiF-IR) enables high-resolution chemical imaging of surfaces with lateral resolution less than 5 nm. Here are some answers to questions about the physical background, practical handling…

Materials Science · Physics 2026-05-05 Daniela Täuber

Single-photon light detection and ranging (LiDAR) is a key technology for depth imaging through complex environments. Despite recent advances, an open challenge is the ability to isolate the LiDAR signal from other spurious sources…

Quantum Physics · Physics 2021-05-18 Jiuxuan Zhao , Ashley Lyons , Arin Can Ulku , Hugo Defienne , Daniele Faccio , Edoardo Charbon

Minfrared spectroscopic imaging (MIRSI) is an emerging class of label-free, biochemically quantitative technologies targeting digital histopathology. Conventional histopathology relies on chemical stains that alter tissue color. This…

Image and Video Processing · Electrical Eng. & Systems 2022-07-26 Mahsa Lotfollahi , Nguyen Tran , Sebastian Berisha , Chalapathi Gajjela , Zhu Han , David Mayerich , Rohith Reddy

The mid-infrared (mid-IR) spectral range is a part of the electromagnetic spectrum in which most of the molecules have vibrational and rotational resonances. Ge-based photonic integrated circuits in this wavelength range have thus seen a…

Quantum illumination is a quantum-optical sensing technique in which an entangled source is exploited to improve the detection of a low-reflectivity object that is immersed in a bright thermal background. Here we describe and analyze a…

Mid-infrared spectroscopy probes molecular vibrations to identify chemical species and functional groups. Therefore, mid-infrared hyperspectral imaging is one of the most powerful and promising candidates for chemical imaging using optical…

Optics · Physics 2023-07-06 Yue Zhao , Shota Kusama , Yuji Furutani , Wei-Hong Huang , Chih-Wei Luo , Takao Fuji