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Large language models (LLMs) are rapidly transforming various domains, including biomedicine and healthcare, and demonstrate remarkable potential from scientific research to new drug discovery. Graph-based retrieval-augmented generation…

Quantitative Methods · Quantitative Biology 2025-11-14 Guofeng Meng , Li Shen , Qiuyan Zhong , Wei Wang , Haizhou Zhang , Xiaozhen Wang

Large Language Models (LLMs) have achieved impressive progress in natural language processing, but their limited ability to retain long-term context constrains performance on document-level or multi-turn tasks. Retrieval-Augmented…

Computation and Language · Computer Science 2025-05-20 Zhangyu Wang , Siyuan Gao , Rong Zhou , Hao Wang , Li Ning

Large language models (LLMs) with retrieval augmented-generation (RAG) have been the optimal choice for scalable generative AI solutions in the recent past. Although RAG implemented with AI agents (agentic-RAG) has been recently…

Artificial Intelligence · Computer Science 2024-11-19 Sohini Roychowdhury , Marko Krema , Anvar Mahammad , Brian Moore , Arijit Mukherjee , Punit Prakashchandra

Large language models (LLMs) in biomedicine face a fundamental conflict between static parameter knowledge and the dynamic nature of clinical evidence. Retrieval-Augmented Generation (RAG) addresses this by grounding generation in external…

Other Quantitative Biology · Quantitative Biology 2025-12-19 Jiawei He , Boya Zhang , Hossein Rouhizadeh , Yingjian Chen , Rui Yang , Jin Lu , Xudong Chen , Nan Liu , Douglas Teodoro

This study presents a novel framework for smart search in digital archival systems, leveraging the capabilities of Large Language Models (LLMs) to enhance information retrieval. By employing a Retrieval-Augmented Generation (RAG) approach,…

Artificial Intelligence · Computer Science 2025-01-14 Ha Dung Nguyen , Thi-Hoang Anh Nguyen , Thanh Binh Nguyen

Recently, Large Language Models (LLMs) have been increasingly used to support various decision-making tasks, assisting humans in making informed decisions. However, when LLMs confidently provide incorrect information, it can lead humans to…

Information Retrieval · Computer Science 2025-10-16 Chaeyun Jang , Deukhwan Cho , Seanie Lee , Hyungi Lee , Juho Lee

While Multimodal Large Language Models (MLLMs) show promising performance in automated electrocardiogram interpretation, it remains unclear whether they genuinely perform actual step-by-step reasoning or just rely on superficial visual…

Machine Learning · Computer Science 2026-03-17 Jungwoo Oh , Hyunseung Chung , Junhee Lee , Min-Gyu Kim , Hangyul Yoon , Ki Seong Lee , Youngchae Lee , Muhan Yeo , Edward Choi

Automated interpretation of electrocardiograms (ECG) has garnered significant attention with the advancements in machine learning methodologies. Despite the growing interest, most current studies focus solely on classification or regression…

Signal Processing · Electrical Eng. & Systems 2023-11-07 Jielin Qiu , Jiacheng Zhu , Shiqi Liu , William Han , Jingqi Zhang , Chaojing Duan , Michael Rosenberg , Emerson Liu , Douglas Weber , Ding Zhao

The integration of Large Language Models (LLMs) into healthcare is constrained by knowledge limitations, hallucinations, and a disconnect from Evidence-Based Medicine (EBM). While Retrieval-Augmented Generation (RAG) offers a solution,…

Computation and Language · Computer Science 2026-02-03 Qiaoyu Zheng , Yuze Sun , Chaoyi Wu , Weike Zhao , Pengcheng Qiu , Yongguo Yu , Kun Sun , Jian Zhang , Yanfeng Wang , Ya Zhang , Weidi Xie

Recent advances in multimodal ECG representation learning center on aligning ECG signals with paired free-text reports. However, suboptimal alignment persists due to the complexity of medical language and the reliance on a full 12-lead…

Machine Learning · Computer Science 2025-02-26 Che Liu , Cheng Ouyang , Zhongwei Wan , Haozhe Wang , Wenjia Bai , Rossella Arcucci

Retrieval-Augmented Generation (RAG) has been shown to enhance the factual accuracy of Large Language Models (LLMs), but existing methods often suffer from limited reasoning capabilities in effectively using the retrieved evidence,…

Computation and Language · Computer Science 2024-10-03 Shayekh Bin Islam , Md Asib Rahman , K S M Tozammel Hossain , Enamul Hoque , Shafiq Joty , Md Rizwan Parvez

Electrocardiography is a very common, non-invasive diagnostic procedure and its interpretation is increasingly supported by automatic interpretation algorithms. The progress in the field of automatic ECG interpretation has up to now been…

Machine Learning · Computer Science 2020-04-29 Nils Strodthoff , Patrick Wagner , Tobias Schaeffter , Wojciech Samek

Retrieval-Augmented Generation (RAG) has become a standard architectural pattern for incorporating domain-specific knowledge into user-facing chat applications powered by Large Language Models (LLMs). RAG systems are characterized by (1) a…

Computation and Language · Computer Science 2025-01-17 Robert Friel , Masha Belyi , Atindriyo Sanyal

Retrieval-Augmented Generation (RAG) has become a widely adopted paradigm for enhancing the reliability of large language models (LLMs). However, RAG systems are sensitive to retrieval strategies that rely on text chunking to construct…

Information Retrieval · Computer Science 2026-03-31 Sun Xu , Tongkai Xu , Baiheng Xie , Li Huang , Qiang Gao , Kunpeng Zhang

Large language models (LLMs) excel in question-answering (QA) tasks, and retrieval-augmented generation (RAG) enhances their precision by incorporating external evidence from diverse sources like web pages, databases, and knowledge graphs.…

Information Retrieval · Computer Science 2025-04-10 Yikuan Xia , Jiazun Chen , Yirui Zhan , Suifeng Zhao , Weipeng Jiang , Chaorui Zhang , Wei Han , Bo Bai , Jun Gao

Large-scale language models (LLMs) have achieved remarkable success across various language tasks but suffer from hallucinations and temporal misalignment. To mitigate these shortcomings, Retrieval-augmented generation (RAG) has been…

Computation and Language · Computer Science 2024-04-30 Zhongzhen Huang , Kui Xue , Yongqi Fan , Linjie Mu , Ruoyu Liu , Tong Ruan , Shaoting Zhang , Xiaofan Zhang

Large language models (LLMs) have shown promise in medical question answering but often struggle with hallucinations and shallow reasoning, particularly in tasks requiring nuanced clinical understanding. Retrieval-augmented generation (RAG)…

Computation and Language · Computer Science 2025-08-25 Ziyu Wang , Elahe Khatibi , Amir M. Rahmani

Electronic health records (EHRs) are long, noisy, and often redundant, posing a major challenge for the clinicians who must navigate them. Large language models (LLMs) offer a promising solution for extracting and reasoning over this…

Computation and Language · Computer Science 2025-08-21 Skatje Myers , Dmitriy Dligach , Timothy A. Miller , Samantha Barr , Yanjun Gao , Matthew Churpek , Anoop Mayampurath , Majid Afshar

Retrieval-Augmented Generation (RAG) enhances large language models (LLMs) by integrating external knowledge, where the LLM's ability to generate responses based on the combination of a given query and retrieved documents is crucial.…

Computation and Language · Computer Science 2025-08-01 Zhehao Tan , Yihan Jiao , Dan Yang , Lei Liu , Jie Feng , Duolin Sun , Yue Shen , Jian Wang , Peng Wei , Jinjie Gu

Electrocardiography (ECG) offers critical cardiovascular insights, such as identifying arrhythmias and myocardial ischemia, but enabling automated systems to answer complex clinical questions directly from ECG signals (ECG-QA) remains a…

Signal Processing · Electrical Eng. & Systems 2025-05-13 Hung Manh Pham , Jialu Tang , Aaqib Saeed , Dong Ma