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Determining the structure and following the structural evolution of molecules undergoing chemical reactions is one of the key goals of ultrafast molecular physics and chemistry. Recently, Coulomb explosion imaging has emerged as a promising…

Deep Research systems have revolutionized how LLMs solve complex questions through iterative reasoning and evidence gathering. However, current systems remain fundamentally constrained to textual web data, overlooking the vast knowledge…

Information Retrieval · Computer Science 2025-10-27 Kuicai Dong , Shurui Huang , Fangda Ye , Wei Han , Zhi Zhang , Dexun Li , Wenjun Li , Qu Yang , Gang Wang , Yichao Wang , Chen Zhang , Yong Liu

Recent advances in machine learning (ML) have expedited materials discovery and design. One significant challenge faced in ML for materials is the expansive combinatorial space of potential materials formed by diverse constituents and their…

Machine Learning · Computer Science 2024-06-13 Hengrui Zhang , Jie Chen , James M. Rondinelli , Wei Chen

Multimodal Large Language Models (MLLMs) can directly consume exam documents, threatening conventional assessments and academic integrity. We present DoPE (Decoy-Oriented Perturbation Encapsulation), a document-layer defense framework that…

Computation and Language · Computer Science 2026-01-21 Ashish Raj Shekhar , Shiven Agarwal , Priyanuj Bordoloi , Yash Shah , Tejas Anvekar , Vivek Gupta

The MolMod database is presented, which is openly accessible at http://molmod.boltzmann-zuse.de/ and contains presently intermolecular force fields for over 150 pure fluids. It was developed and is maintained by the Boltzmann-Zuse Society…

Computational Physics · Physics 2019-04-11 Simon Stephan , Martin Thomas Horsch , Jadran Vrabec , Hans Hasse

Multimodel Large Language Models(MLLMs) have achieved promising OCR-free Document Understanding performance by increasing the supported resolution of document images. However, this comes at the cost of generating thousands of visual tokens…

Computer Vision and Pattern Recognition · Computer Science 2024-09-10 Anwen Hu , Haiyang Xu , Liang Zhang , Jiabo Ye , Ming Yan , Ji Zhang , Qin Jin , Fei Huang , Jingren Zhou

Large Language Models (LLMs) stand at the forefront of a number of Natural Language Processing (NLP) tasks. Despite the widespread adoption of LLMs in NLP, much of their potential in broader fields remains largely unexplored, and…

Machine Learning · Computer Science 2024-03-11 Zhiqiang Zhong , Kuangyu Zhou , Davide Mottin

Molecule discovery is a pivotal research field, impacting everything from medicine to materials. Recently, Large Language Models (LLMs) have been widely adopted in molecular understanding and generation, serving as a bridge between the…

Computation and Language · Computer Science 2026-04-29 Jiatong Li , Yunqing Liu , Wei Liu , Jingdi Le , Di Zhang , Wenqi Fan , Dongzhan Zhou , Yuqiang Li , Qing Li

Chemical language models (CLMs) are prominent for their effectiveness in exploring chemical space and enabling molecular engineering. However, while exploring chemical-linguistic space, CLMs suffer from the gap between natural language and…

Computational Engineering, Finance, and Science · Computer Science 2025-01-07 Liuzhenghao Lv , Hao Li , Yu Wang , Zhiyuan Yan , Zijun Chen , Zongying Lin , Li Yuan , Yonghong Tian

We present a perspective on molecular machine learning (ML) in the field of chemical process engineering. Recently, molecular ML has demonstrated great potential in (i) providing highly accurate predictions for properties of pure components…

Chemical Physics · Physics 2025-09-01 Jan G. Rittig , Manuel Dahmen , Martin Grohe , Philippe Schwaller , Alexander Mitsos

Molecule design is a multifaceted approach that leverages computational methods and experiments to optimize molecular properties, fast-tracking new drug discoveries, innovative material development, and more efficient chemical processes.…

Computation and Language · Computer Science 2024-08-23 Sakhinana Sagar Srinivas , Venkataramana Runkana

Drug discovery projects entail cycles of design, synthesis, and testing that yield a series of chemically related small molecules whose properties, such as binding affinity to a given target protein, are progressively tailored to a…

Machine Learning · Computer Science 2020-02-10 Paul Maragakis , Hunter Nisonoff , Brian Cole , David E. Shaw

Virtual Screening is an essential technique in the early phases of drug discovery, aimed at identifying promising drug candidates from vast molecular libraries. Recently, ligand-based virtual screening has garnered significant attention due…

Biomolecules · Quantitative Biology 2024-11-22 Gengmo Zhou , Zhen Wang , Feng Yu , Guolin Ke , Zhewei Wei , Zhifeng Gao

Documents are visually rich structures that convey information through text, but also figures, page layouts, tables, or even fonts. Since modern retrieval systems mainly rely on the textual information they extract from document pages to…

Information Retrieval · Computer Science 2025-03-03 Manuel Faysse , Hugues Sibille , Tony Wu , Bilel Omrani , Gautier Viaud , Céline Hudelot , Pierre Colombo

We introduce a new molecular dataset, named Alchemy, for developing machine learning models useful in chemistry and material science. As of June 20th 2019, the dataset comprises of 12 quantum mechanical properties of 119,487 organic…

Multimodal information extraction (MIE) is crucial for scientific literature, where valuable data is often spread across text, figures, and tables. In materials science, extracting structured information from research articles can…

Computation and Language · Computer Science 2024-10-29 Ghazal Khalighinejad , Sharon Scott , Ollie Liu , Kelly L. Anderson , Rickard Stureborg , Aman Tyagi , Bhuwan Dhingra

The automated extraction of structured questions from paper-based mathematics exams is fundamental to intelligent education, yet remains challenging in real-world settings due to severe visual noise. Existing benchmarks mainly focus on…

Computer Vision and Pattern Recognition · Computer Science 2026-01-16 Chenyue Zhou , Jiayi Tuo , Shitong Qin , Wei Dai , Mingxuan Wang , Ziwei Zhao , Duoyang Li , Shiyang Su , Yanxi Lu , Yanbiao Ma

Large Language Models (LLMs) have achieved remarkable success and have been applied across various scientific fields, including chemistry. However, many chemical tasks require the processing of visual information, which cannot be…

Molecular structure elucidation involves deducing a molecule's structure from various types of spectral data, which is crucial in chemical experimental analysis. While large language models (LLMs) have shown remarkable proficiency in…

Computation and Language · Computer Science 2025-07-01 Xiang Zhuang , Bin Wu , Jiyu Cui , Kehua Feng , Xiaotong Li , Huabin Xing , Keyan Ding , Qiang Zhang , Huajun Chen

Molecular optimization is a key challenge in drug discovery and material science domain, involving the design of molecules with desired properties. Existing methods focus predominantly on single-property optimization, necessitating…

Machine Learning · Computer Science 2024-09-13 Aye Phyu Phyu Aung , Jay Chaudhary , Ji Wei Yoon , Senthilnath Jayavelu
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