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Neuroimaging biomarkers that distinguish between typical brain aging and Alzheimer's disease (AD) are valuable for determining how much each contributes to cognitive decline. Machine learning models can derive multi-variate brain change…

Current neuroimaging techniques provide paths to investigate the structure and function of the brain in vivo and have made great advances in understanding Alzheimer's disease (AD). However, the group-level analyses prevalently used for…

Quantitative Methods · Quantitative Biology 2021-05-31 Nanyan Zhu , Chen Liu , Xinyang Feng , Dipika Sikka , Sabrina Gjerswold-Selleck , Scott A. Small , Jia Guo

With the increased need for multi-center magnetic resonance imaging studies, problems arise related to differences in hardware and software between centers. Namely, current algorithms for brain volume quantification are unreliable for the…

Image and Video Processing · Electrical Eng. & Systems 2019-11-12 Maria Ines Meyer , Ezequiel de la Rosa , Koen Van Leemput , Diana M. Sima

Alzheimer's disease (AD) diagnosis is complex, requiring the integration of imaging and clinical data for accurate assessment. While deep learning has shown promise in brain MRI analysis, it often functions as a black box, limiting…

Image and Video Processing · Electrical Eng. & Systems 2025-03-04 Yexiao He , Ziyao Wang , Yuning Zhang , Tingting Dan , Tianlong Chen , Guorong Wu , Ang Li

Inter-scanner and inter-protocol discrepancy in MRI datasets are known to lead to significant quantification variability. Hence image-to-image or scanner-to-scanner translation is a crucial frontier in the area of medical image analysis…

Image and Video Processing · Electrical Eng. & Systems 2021-02-16 Xiaobin Hu

Deep neural networks (DNNs) have become the driving force behind recent artificial intelligence (AI) research. An important problem with implementing a neural network is the design of its architecture. Typically, such an architecture is…

Neural and Evolutionary Computing · Computer Science 2021-03-30 Shayan Hassantabar , Zeyu Wang , Niraj K. Jha

Retrospective analysis of brain MRI scans acquired in the clinic has the potential to enable neuroimaging studies with sample sizes much larger than those found in research datasets. However, analysing such clinical images "in the wild" is…

Image and Video Processing · Electrical Eng. & Systems 2023-01-06 Benjamin Billot , Magdamo Colin , Sean E. Arnold , Sudeshna Das , Juan. E. Iglesias

Objective: This paper presents an Alzheimer's disease (AD) detection method based on learning structural similarity between Magnetic Resonance Images (MRIs) and representing this similarity as a graph. Methods: We construct the similarity…

Computer Vision and Pattern Recognition · Computer Science 2021-03-01 Kuo Yang , Emad A. Mohammed , Behrouz H. Far

Thalamic alterations are relevant to many neurological disorders including Alzheimer's disease, Parkinson's disease and multiple sclerosis. Routine interventions to improve symptom severity in movement disorders, for example, often consist…

Computer Vision and Pattern Recognition · Computer Science 2018-07-31 Veronica Corona , Jan Lellmann , Peter Nestor , Carola-Bibiane Schoenlieb , Julio Acosta-Cabronero

Deep learning holds immense promise for transforming medical image analysis, yet its clinical generalization remains profoundly limited. A major barrier is data heterogeneity. This is particularly true in Magnetic Resonance Imaging, where…

Computer Vision and Pattern Recognition · Computer Science 2025-12-09 Mehmet Yigit Avci , Pedro Borges , Virginia Fernandez , Paul Wright , Mehmet Yigitsoy , Sebastien Ourselin , Jorge Cardoso

We propose a novel framework for Alzheimer's disease (AD) detection using brain MRIs. The framework starts with a data augmentation method called Brain-Aware Replacements (BAR), which leverages a standard brain parcellation to replace…

Computer Vision and Pattern Recognition · Computer Science 2022-07-22 Mehmet Saygın Seyfioğlu , Zixuan Liu , Pranav Kamath , Sadjyot Gangolli , Sheng Wang , Thomas Grabowski , Linda Shapiro

Deep networks are now ubiquitous in large-scale multi-center imaging studies. However, the direct aggregation of images across sites is contraindicated for downstream statistical and deep learning-based image analysis due to inconsistent…

Image and Video Processing · Electrical Eng. & Systems 2021-04-16 Mengwei Ren , Neel Dey , James Fishbaugh , Guido Gerig

Compressed Sensing MRI reconstructs images of the body's internal anatomy from undersampled measurements, thereby reducing scan time. Recently, deep learning has shown great potential for reconstructing high-fidelity images from highly…

Image and Video Processing · Electrical Eng. & Systems 2025-04-07 Armeet Singh Jatyani , Jiayun Wang , Aditi Chandrashekar , Zihui Wu , Miguel Liu-Schiaffini , Bahareh Tolooshams , Anima Anandkumar

Alzheimer's disease (AD) is a progressive neurodegenerative disorder in which pathological changes begin many years before the onset of clinical symptoms, making early detection essential for timely intervention. T1-weighted (T1w) Magnetic…

Computer Vision and Pattern Recognition · Computer Science 2026-01-21 Jason Qiu

Supervised learning has been very successful for automatic segmentation of images from a single scanner. However, several papers report deteriorated performances when using classifiers trained on images from one scanner to segment images…

Computer Vision and Pattern Recognition · Computer Science 2017-03-16 Veronika Cheplygina , Annegreet van Opbroek , M. Arfan Ikram , Meike W. Vernooij , Marleen de Bruijne

Imaging in clinical routine is subject to changing scanner protocols, hardware, or policies in a typically heterogeneous set of acquisition hardware. Accuracy and reliability of deep learning models suffer from those changes as data and…

Machine Learning · Computer Science 2021-06-08 Matthias Perkonigg , Johannes Hofmanninger , Georg Langs

Detection of Alzheimer's Disease (AD) from neuroimaging data such as MRI through machine learning have been a subject of intense research in recent years. Recent success of deep learning in computer vision have progressed such research…

Computer Vision and Pattern Recognition · Computer Science 2017-12-01 Marcia Hon , Naimul Khan

Multi-modality imaging improves disease diagnosis and reveals distinct deviations in tissues with anatomical properties. The existence of completely aligned and paired multi-modality neuroimaging data has proved its effectiveness in brain…

Image and Video Processing · Electrical Eng. & Systems 2023-09-26 Guoyang Xie , Yawen Huang , Jinbao Wang , Jiayi Lyu , Feng Zheng , Yefeng Zheng , Yaochu Jin

Transfer learning represents a recent paradigm shift in the way we build artificial intelligence (AI) systems. In contrast to training task-specific models, transfer learning involves pre-training deep learning models on a large corpus of…

With the advent of convolutional neural networks~(CNN), supervised learning methods are increasingly being used for whole brain segmentation. However, a large, manually annotated training dataset of labeled brain images required to train…

Computer Vision and Pattern Recognition · Computer Science 2019-03-05 Amod Jog , Andrew Hoopes , Douglas N. Greve , Koen Van Leemput , Bruce Fischl