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Generative Large Language Models (LLMs) hold significant promise in healthcare, demonstrating capabilities such as passing medical licensing exams and providing clinical knowledge. However, their current use as information retrieval tools…

Large language models (LLMs) are omnipresent, however their practical deployment is challenging due to their ever increasing computational and memory demands. Quantization is one of the most effective ways to make them more compute and…

Machine Learning · Computer Science 2024-09-04 Yelysei Bondarenko , Riccardo Del Chiaro , Markus Nagel

Despite significant advances in foundation models like DeepSeek-R1 and ChatGPT, their deployment in medical settings faces critical challenges including computational requirements and professional knowledge barriers. This paper presents an…

Computation and Language · Computer Science 2025-07-23 Mingda Zhang , Jianglong Qin

Running Large Language Models (LLMs) on edge devices is constrained by high compute and memory demands posing a barrier for real-time applications in sectors like healthcare, education, and embedded systems. Current solutions such as…

Low Rank Adaptation (LoRA) has emerged as one of the most widely adopted methods for Parameter Efficient Fine-Tuning (PEFT) of Large Language Models (LLMs). LoRA reduces the number of trainable parameters and memory usage while achieving…

Computation and Language · Computer Science 2024-05-03 Justin Zhao , Timothy Wang , Wael Abid , Geoffrey Angus , Arnav Garg , Jeffery Kinnison , Alex Sherstinsky , Piero Molino , Travis Addair , Devvret Rishi

Training and fine-tuning large language models (LLMs) come with challenges related to memory and computational requirements due to the increasing size of the model weights and the optimizer states. Various techniques have been developed to…

Machine Learning · Computer Science 2025-12-09 Yehonathan Refael , Jonathan Svirsky , Boris Shustin , Wasim Huleihel , Ofir Lindenbaum

Frontier large language models (LLMs), such as GPT-5, Claude 4.5, Gemini 3, Llama 4, and DeepSeek-R1, represent a transformative class of AI tools capable of revolutionizing various aspects of healthcare by generating human-like responses…

Large language models (LLMs) have immense potential to make information more accessible, particularly in medicine, where complex medical jargon can hinder patient comprehension of clinical notes. We developed a patient-facing tool using…

Large language models (LLMs) in biomedicine face a fundamental conflict between static parameter knowledge and the dynamic nature of clinical evidence. Retrieval-Augmented Generation (RAG) addresses this by grounding generation in external…

Other Quantitative Biology · Quantitative Biology 2025-12-19 Jiawei He , Boya Zhang , Hossein Rouhizadeh , Yingjian Chen , Rui Yang , Jin Lu , Xudong Chen , Nan Liu , Douglas Teodoro

Medical consultation dialogues contain critical clinical information, yet their unstructured nature hinders effective utilization in diagnosis and treatment. Traditional methods, relying on rule-based or shallow machine learning techniques,…

Computation and Language · Computer Science 2025-04-24 Shuguang Zhao , Qiangzhong Feng , Zhiyang He , Peipei Sun , Yingying Wang , Xiaodong Tao , Xiaoliang Lu , Mei Cheng , Xinyue Wu , Yanyan Wang , Wei Liang

We propose a simple approach for memory-efficient adaptation of pretrained language models. Our approach uses an iterative algorithm to decompose each pretrained matrix into a high-precision low-rank component and a memory-efficient…

Computation and Language · Computer Science 2024-08-28 Han Guo , Philip Greengard , Eric P. Xing , Yoon Kim

This paper explores the use of large language models (LLMs) for annotating document utility in training retrieval and retrieval-augmented generation (RAG) systems, aiming to reduce dependence on costly human annotations. We address the gap…

Information Retrieval · Computer Science 2025-10-10 Hengran Zhang , Minghao Tang , Keping Bi , Jiafeng Guo , Shihao Liu , Daiting Shi , Dawei Yin , Xueqi Cheng

Large Language Models (LLMs) demonstrate remarkable capabilities but remain limited by their reliance on static training data. Retrieval-Augmented Generation (RAG) addresses this constraint by retrieving external knowledge during inference,…

Computation and Language · Computer Science 2026-02-19 Xingda Lyu , Gongfu Lyu , Zitai Yan , Yuxin Jiang

This study analyzes the performance of domain-specific Large Language Models (LLMs) for the medical field by integrating Retrieval-Augmented Generation (RAG) systems within a federated learning framework. Leveraging the inherent advantages…

Computation and Language · Computer Science 2025-01-09 Jincheol Jung , Hongju Jeong , Eui-Nam Huh

We present a refined approach to biomedical question-answering (QA) services by integrating large language models (LLMs) with Multi-BERT configurations. By enhancing the ability to process and prioritize vast amounts of complex biomedical…

Computation and Language · Computer Science 2024-10-18 Cheng Qian , Xianglong Shi , Shanshan Yao , Yichen Liu , Fengming Zhou , Zishu Zhang , Junaid Akram , Ali Braytee , Ali Anaissi

Improving the efficiency of inference in Large Language Models (LLMs) is a critical area of research. Post-training Quantization (PTQ) is a popular technique, but it often faces challenges at low-bit levels, particularly in downstream…

Computer Vision and Pattern Recognition · Computer Science 2025-04-15 Wenjin Ke , Zhe Li , Dong Li , Lu Tian , Emad Barsoum

Memory, additional information beyond the training of large language models (LLMs), is crucial to various real-world applications, such as personal assistant. The two mainstream solutions to incorporate memory into the generation process…

Computation and Language · Computer Science 2025-03-21 Jiale Wei , Shuchi Wu , Ruochen Liu , Xiang Ying , Jingbo Shang , Fangbo Tao

Domain-adapted open-weight large language models (LLMs) offer promising healthcare applications, from queryable knowledge bases to multimodal assistants, with the crucial advantage of local deployment for privacy preservation. However,…

Computation and Language · Computer Science 2025-10-22 Lara Ahrens , Wilhelm Haverkamp , Nils Strodthoff

Vision Language Models (VLMs) integrate visual and text modalities to enable multimodal understanding and generation. These models typically combine a Vision Transformer (ViT) as an image encoder and a Large Language Model (LLM) for text…

Computer Vision and Pattern Recognition · Computer Science 2025-08-19 Krishna Teja Chitty-Venkata , Murali Emani , Venkatram Vishwanath

The emergent abilities of large language models (LLMs) have demonstrated great potential in solving medical questions. They can possess considerable medical knowledge, but may still hallucinate and are inflexible in the knowledge updates.…

Computation and Language · Computer Science 2024-10-14 Guangzhi Xiong , Qiao Jin , Xiao Wang , Minjia Zhang , Zhiyong Lu , Aidong Zhang