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Despite best efforts, various challenges remain in the creation and maintenance processes of digital twins (DTs). One of those primary challenges is the constant, continuous and omnipresent evolution of systems, their user's needs and their…

Software Engineering · Computer Science 2024-11-01 Joost Mertens , Stefan Klikovits , Francis Bordeleau , Joachim Denil , Øystein Haugen

Tumor segmentation plays a critical role in histopathology, but it requires costly, fine-grained image-mask pairs annotated by pathologists. Thus, synthesizing histopathology data to expand the dataset is highly desirable. Previous works…

Computer Vision and Pattern Recognition · Computer Science 2025-03-07 Hong Liu , Haosen Yang , Evi M. C. Huijben , Mark Schuiveling , Ruisheng Su , Josien P. W. Pluim , Mitko Veta

The accurate and efficient modeling of nuclear reactor transients is crucial for ensuring safe and optimal reactor operation. Traditional physics-based models, while valuable, can be computationally intensive and may not fully capture the…

Applications · Statistics 2024-11-28 James Daniell , Kazuma Kobayashi , Ayodeji Alajo , Syed Bahauddin Alam

AI models for lung cancer screening are limited by data scarcity, impacting generalizability and clinical applicability. Generative models address this issue but are constrained by training data variability. We introduce SYN-LUNGS, a…

With the advanced imaging technology, digital pathology imaging of tumor tissue slides is becoming a routine clinical procedure for cancer diagnosis. This process produces massive imaging data that capture histological details in high…

Applications · Statistics 2020-12-10 Esteban Fernández Morales , Cong Zhang , Guanghua Xiao , Chul Moon , Qiwei Li

Modern wireless applications demand testing environments that capture the full complexity of next-generation (NextG) cellular networks. While digital twins promise realistic emulation, existing solutions often compromise on physical-layer…

Networking and Internet Architecture · Computer Science 2026-05-06 Ali Mamaghani , Ushasi Ghosh , Srinivas Shakkottai , Dinesh Bharadia , Ish Kumar Jain

Cancer pathology is unique to a given individual, and developing personalized diagnostic and treatment protocols are a primary concern. Mathematical modeling and simulation is a promising approach to personalized cancer medicine. Yet, the…

Tissues and Organs · Quantitative Biology 2020-08-03 Alvaro Köhn-Luque , Xiaoran Lai , Arnoldo Frigessi

Musculoskeletal disorders (MSDs) are a leading cause of disability worldwide, requiring advanced diagnostic and therapeutic tools for personalised assessment and treatment. Effective management of MSDs involves the interaction of…

Image and Video Processing · Electrical Eng. & Systems 2025-07-28 Martina Paccini , Simone Cammarasana , Giuseppe Patanè

Addressing the growing need for organized data on tumor homing peptides (THPs), we present TumorHoPe2, a manually curated database offering extensive details on experimentally validated THPs. This represents a significant update to…

Biomolecules · Quantitative Biology 2025-05-28 Diksha Kashyap , Devanshi Gupta , Naman Kumar Mehta , Gajendra P. S. Raghava

Physics-informed neural networks (PINNs) are neural networks that embed the laws of dynamical systems modeled by differential equations into their loss function as constraints. In this work, we present a PINN framework applied to oncology.…

Machine Learning · Computer Science 2025-10-16 Kayode Olumoyin , Katarzyna Rejniak

Generation IV (Gen-IV) nuclear power plants are envisioned to replace the current reactor fleet, bringing improvements in performance, safety, reliability, and sustainability. However, large cost investments currently inhibit the deployment…

Systems and Control · Electrical Eng. & Systems 2025-12-02 Jasmin Y. Lim , Dimitrios Pylorof , Humberto E. Garcia , Karthik Duraisamy

Medical image processing demands specialized software that handles high-dimensional volumetric data, heterogeneous file formats, and domain-specific training procedures. Existing frameworks either provide low-level components that require…

Computer Vision and Pattern Recognition · Computer Science 2026-02-25 Tianhao Fu , Yucheng Chen

Precise and timely simulation of a structure's dynamic behavior is crucial for evaluating its performance and assessing its health status. Traditional numerical methods are often limited by high computational costs and low efficiency, while…

Computational Engineering, Finance, and Science · Computer Science 2025-06-24 Jun Zhang , Tong Zhang , Ying Wang

Thyroid cancer is a common endocrine carcinoma that occurs in the thyroid gland. Much effort has been invested in improving its diagnosis, and thyroidectomy remains the primary treatment method. A successful operation without unnecessary…

Machine Learning · Computer Science 2022-03-31 Nan Miles Xi , Lin Wang , Chuanjia Yang

Cancer diagnosis, prognosis, and therapeutic response predictions are based on morphological information from histology slides and molecular profiles from genomic data. However, most deep learning-based objective outcome prediction and…

Computer Vision and Pattern Recognition · Computer Science 2020-09-04 Richard J. Chen , Ming Y. Lu , Jingwen Wang , Drew F. K. Williamson , Scott J. Rodig , Neal I. Lindeman , Faisal Mahmood

Digital twin (DT) offers significant opportunities for enhancing facility management (FM) in campus environments. However, existing research often focuses narrowly on isolated domains, such as point-cloud geometry or energy analytics,…

Systems and Control · Electrical Eng. & Systems 2025-12-16 Thyda Siv

Datacenters are the backbone of our digital society, but raise numerous operational challenges. We envision digital twins becoming primary instruments in datacenter operations, continuously and autonomously helping with major operational…

Distributed, Parallel, and Cluster Computing · Computer Science 2026-04-14 Radu Nicolae , Jules van der Toorn , Stavriana Kraniti , Houcen Liu , Alexandru Iosup

This article discusses the use of digital twins for products made of polymer composite materials. The design of new products from polymer composite materials, both within the framework of the traditional and new direction of cloud…

Robotics · Computer Science 2021-09-14 Maksim Kubrikov , Mikhail Saramud , Angelina Petetskaya , Evgeniy Talay

The rapidly evolving field of digital oncopathology faces significant challenges, including the need to address diverse and complex clinical questions, often involving rare conditions, with limited availability of labeled data. These…

Image and Video Processing · Electrical Eng. & Systems 2024-09-05 Jonathan Zalach , Inbal Gazy , Assaf Avinoam , Ron Sinai , Eran Shmuel , Inbar Gilboa , Christine Swisher , Naim Matasci , Reva Basho , David B. Agus

Despite advances in methods to interrogate tumor biology, the observational and population-based approach of classical cancer research and clinical oncology does not enable anticipation of tumor outcomes to hasten the discovery of cancer…

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