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Alzheimer's Disease Analysis Model (ADAM) is a multi-agent reasoning large language model (LLM) framework designed to integrate and analyze multimodal data, including microbiome profiles, clinical datasets, and external knowledge bases, to…

Artificial Intelligence · Computer Science 2025-08-22 Ziyuan Huang , Vishaldeep Kaur Sekhon , Roozbeh Sadeghian , Maria L. Vaida , Cynthia Jo , Doyle Ward , Vanni Bucci , John P. Haran

Depression is one of the leading causes of disability worldwide, posing a severe burden on individuals, healthcare systems, and society at large. Recent advancements in Large Language Models (LLMs) have shown promise in addressing mental…

Computation and Language · Computer Science 2025-02-11 Shiyu Teng , Jiaqing Liu , Rahul Kumar Jain , Shurong Chai , Ruibo Hou , Tomoko Tateyama , Lanfen Lin , Yen-wei Chen

We introduce TableLLM, a robust large language model (LLM) with 8 billion parameters, purpose-built for proficiently handling tabular data manipulation tasks, whether they are embedded within documents or spreadsheets, catering to…

Computation and Language · Computer Science 2025-02-18 Xiaokang Zhang , Sijia Luo , Bohan Zhang , Zeyao Ma , Jing Zhang , Yang Li , Guanlin Li , Zijun Yao , Kangli Xu , Jinchang Zhou , Daniel Zhang-Li , Jifan Yu , Shu Zhao , Juanzi Li , Jie Tang

Coronavirus Disease 2019 (COVID-19), which emerged in 2019, has caused millions of deaths worldwide. Although effective vaccines have been developed to mitigate severe symptoms, certain populations, particularly the elderly and those with…

Computation and Language · Computer Science 2024-12-06 Shengjun Zhu , Siyu Liu , Yang Li , Qing Lei , Hongyan Hou , Hewei Jiang , Shujuan Guo , Feng Wang , Rongshang Chen , Xionglin Fan , Shengce Tao , Jiaxin Cai

Large language models (LLMs) have achieved remarkable performance on diverse benchmarks, yet existing evaluation practices largely rely on coarse summary metrics that obscure underlying reasoning abilities. In this work, we propose novel…

Methodology · Statistics 2026-03-17 Jia Liu , Zhiyu Xu , Yuqi Gu

Cognitive Behavioral Therapy (CBT) is a well-established, evidence-based treatment for Major Depressive Disorder. Unfortunately, there exist significant barriers to individuals accessing CBT, including cost, scarcity of therapists and…

Artificial Intelligence · Computer Science 2025-09-23 Talha Tahir

Mental health has attracted substantial attention in recent years and LLM can be an effective technology for alleviating this problem owing to its capability in text understanding and dialogue. However, existing research in this domain…

Computation and Language · Computer Science 2024-12-09 Jinpeng Hu , Tengteng Dong , Luo Gang , Hui Ma , Peng Zou , Xiao Sun , Dan Guo , Xun Yang , Meng Wang

The global increase in mental illness requires innovative detection methods for early intervention. Social media provides a valuable platform to identify mental illness through user-generated content. This systematic review examines machine…

Machine Learning · Computer Science 2025-02-18 Yuchen Cao , Jianglai Dai , Zhongyan Wang , Yeyubei Zhang , Xiaorui Shen , Yunchong Liu , Yexin Tian

Large language models (LLMs) are increasingly used in medical fields. In mental health support, the early identification of linguistic markers associated with mental health conditions can provide valuable support to mental health…

Computation and Language · Computer Science 2026-02-03 Konstantinos Skianis , A. Seza Doğruöz , John Pavlopoulos

Foundation large language models (LLMs) have shown an impressive ability to solve tasks across a wide range of fields including health. To effectively solve personalized health tasks, LLMs need the ability to ingest a diversity of data…

Major depressive disorder represents one of the most significant global health challenges of the 21st century, affecting millions of people worldwide and creating substantial economic and social burdens. While conventional antidepressant…

Computation and Language · Computer Science 2025-07-08 Linyan Zou

Depression remains a pressing global mental health issue, driving considerable research into AI-driven detection approaches. While pre-trained models, particularly speech self-supervised models (SSL Models), have been applied to depression…

Audio and Speech Processing · Electrical Eng. & Systems 2025-03-11 Xiangyu Zhang , Beena Ahmed , Julien Epps

This study aims to simulate real-world clinical scenarios to systematically evaluate the ability of Large Language Models (LLMs) to extract core medical information from patient chief complaints laden with noise and redundancy, and to…

Artificial Intelligence · Computer Science 2025-12-15 Yuan Shen , Xiaojun Wu , Linghua Yu

Depression is a major mental health condition that severely impacts the emotional and physical well-being of individuals. The simple nature of data collection from social media platforms has attracted significant interest in properly…

Computer Vision and Pattern Recognition · Computer Science 2025-08-12 Md Rezwanul Haque , Md. Milon Islam , S M Taslim Uddin Raju , Hamdi Altaheri , Lobna Nassar , Fakhri Karray

With more than 300 million people depressed worldwide, depression is a global problem. Due to access barriers such as social stigma, cost, and treatment availability, 60% of mentally-ill adults do not receive any mental health services.…

Computer Vision and Pattern Recognition · Computer Science 2018-11-28 Albert Haque , Michelle Guo , Adam S Miner , Li Fei-Fei

Background: Depression is a major public health concern, affecting an estimated five percent of the global population. Early and accurate diagnosis is essential to initiate effective treatment, yet recognition remains challenging in many…

Signal Processing · Electrical Eng. & Systems 2025-11-21 Jana Weber , Marcel Weber , Juan Miguel Lopez Alcaraz

Large language models (LLMs) show promise for improving the efficiency of qualitative analysis in large, multi-site health-services research. Yet methodological guidance for LLM integration into qualitative analysis and evidence of their…

Computation and Language · Computer Science 2026-01-22 Sasha Ronaghi , Emma-Louise Aveling , Maria Levis , Rachel Lauren Ross , Emily Alsentzer , Sara Singer

Tabular data is often hidden in text, particularly in medical diagnostic reports. Traditional machine learning (ML) models designed to work with tabular data, cannot effectively process information in such form. On the other hand, large…

Machine Learning · Computer Science 2023-06-09 Aleksa Bisercic , Mladen Nikolic , Mihaela van der Schaar , Boris Delibasic , Pietro Lio , Andrija Petrovic

Mental health forums offer valuable insights into psychological issues, stressors, and potential solutions. We propose MHINDR, a large language model (LLM) based framework integrated with DSM-5 criteria to analyze user-generated text,…

Social and Information Networks · Computer Science 2025-10-01 Vaishali Agarwal , Sachin Thukral , Arnab Chatterjee

We introduce LLMD, a large language model designed to analyze a patient's medical history based on their medical records. Along with domain knowledge, LLMD is trained on a large corpus of records collected over time and across facilities,…