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Patient matching is the process of linking patients to appropriate clinical trials by accurately identifying and matching their medical records with trial eligibility criteria. We propose LLM-Match, a novel framework for patient matching…

Computation and Language · Computer Science 2025-03-26 Xiaodi Li , Shaika Chowdhury , Chung Il Wi , Maria Vassilaki , Xiaoke Liu , Terence T Sio , Owen Garrick , Young J Juhn , James R Cerhan , Cui Tao , Nansu Zong

Existing depression screening predominantly relies on standardized questionnaires (e.g., PHQ-9, BDI), which suffer from high misdiagnosis rates (18-34% in clinical studies) due to their static, symptom-counting nature and susceptibility to…

Neurons and Cognition · Quantitative Biology 2025-04-24 Zhenguang Zhong , Zhixuan Wang

Online health resources and large language models (LLMs) are increasingly used as a first point of contact for medical decision-making, yet their reliability in healthcare remains limited by low accuracy, lack of transparency, and…

Artificial Intelligence · Computer Science 2026-04-22 Yujia Liu , Sophia Yu , Hongyue Jin , Jessica Wen , Alexander Qian , Terrence Lee , Mattheus Ramsis , Gi Won Choi , Lianhui Qin , Xin Liu , Edward J. Wang

Large Language Models (LLMs) can play a vital role in psychotherapy by adeptly handling the crucial task of cognitive reframing and overcoming challenges such as shame, distrust, therapist skill variability, and resource scarcity. Previous…

Human-Computer Interaction · Computer Science 2025-01-28 Mengxi Xiao , Qianqian Xie , Ziyan Kuang , Zhicheng Liu , Kailai Yang , Min Peng , Weiguang Han , Jimin Huang

Mental health is increasingly critical in contemporary healthcare, with psychotherapy demanding dynamic, context-sensitive interactions that traditional NLP methods struggle to capture. Large Language Models (LLMs) offer significant…

Computation and Language · Computer Science 2025-06-30 Hongbin Na , Yining Hua , Zimu Wang , Tao Shen , Beibei Yu , Lilin Wang , Wei Wang , John Torous , Ling Chen

While confidence estimation is a promising direction for mitigating hallucinations in Large Language Models (LLMs), current research overwhelmingly focuses on single-turn settings. The dynamics of model confidence in multi-turn…

Computation and Language · Computer Science 2026-05-15 Caiqi Zhang , Ruihan Yang , Xiaochen Zhu , Chengzu Li , Tiancheng Hu , Yijiang River Dong , Deqing Yang , Nigel Collier

Cognitive impairment is becoming a major public health challenge. Cognitive Stimulation Therapy (CST) is an effective intervention for cognitive impairment, but traditional methods are difficult to scale, and existing digital systems…

Computation and Language · Computer Science 2026-03-12 Jiyue Jiang , Yanyu Chen , Pengan Chen , Kai Liu , Jingqi Zhou , Zheyong Zhu , He Hu , Fei Ma , Qi Tian , Chuan Wu

User simulation has long played a vital role in computer science due to its potential to support a wide range of applications. Language, as the primary medium of human communication, forms the foundation of social interaction and behavior.…

Large Language Models (LLMs) have sparked substantial interest and debate concerning their potential emergence of Theory of Mind (ToM) ability. Theory of mind evaluations currently focuses on testing models using machine-generated data or…

Computation and Language · Computer Science 2024-10-08 Chunkit Chan , Cheng Jiayang , Yauwai Yim , Zheye Deng , Wei Fan , Haoran Li , Xin Liu , Hongming Zhang , Weiqi Wang , Yangqiu Song

Multimodal large language models (MLLMs) hold considerable promise for applications in healthcare. However, their deployment in safety-critical settings is hindered by two key limitations: (i) sensitivity to prompt design, and (ii) a…

Computer Vision and Pattern Recognition · Computer Science 2025-10-14 Anita Kriz , Elizabeth Laura Janes , Xing Shen , Tal Arbel

Recent developments in large language models (LLMs) have unlocked new opportunities for healthcare, from information synthesis to clinical decision support. These new LLMs are not just capable of modeling language, but can also act as…

Human-Computer Interaction · Computer Science 2023-09-21 Nikita Mehandru , Brenda Y. Miao , Eduardo Rodriguez Almaraz , Madhumita Sushil , Atul J. Butte , Ahmed Alaa

Large language models (LLMs) are increasingly used for emotional support and mental health-related interactions outside clinical settings, yet little is known about how people evaluate and relate to these systems in everyday use. We analyze…

Computation and Language · Computer Science 2026-01-29 Elham Aghakhani , Rezvaneh Rezapour

Large language models (LLMs) have shown promise for mental health support, yet training such models is constrained by the scarcity and sensitivity of real counseling dialogues. In this article, we present MindChat, a privacy-preserving LLM…

Artificial Intelligence · Computer Science 2026-01-27 Dong Xue , Jicheng Tu , Ming Wang , Xin Yan , Fangzhou Liu , Jie Hu

Workshop courses designed to foster creativity are gaining popularity. However, even experienced faculty teams find it challenging to realize a holistic evaluation that accommodates diverse perspectives. Adequate deliberation is essential…

Computers and Society · Computer Science 2025-07-04 Toru Ishida , Tongxi Liu , Hailong Wang , William K. Cheunga

Traditionally, offline datasets have been used to evaluate task-oriented dialogue (TOD) models. These datasets lack context awareness, making them suboptimal benchmarks for conversational systems. In contrast, user-agents, which are…

Computation and Language · Computer Science 2024-11-18 Taaha Kazi , Ruiliang Lyu , Sizhe Zhou , Dilek Hakkani-Tur , Gokhan Tur

Understanding the dynamics of counseling conversations is an important task, yet it is a challenging NLP problem regardless of the recent advance of Transformer-based pre-trained language models. This paper proposes a systematic approach to…

Computation and Language · Computer Science 2024-02-23 Younghun Lee , Dan Goldwasser , Laura Schwab Reese

Recent advancements in large language models (LLMs) promise to expand mental health interventions by emulating therapeutic techniques, potentially easing barriers to care. Yet there is a lack of real-world empirical evidence evaluating the…

Human-Computer Interaction · Computer Science 2025-01-28 Yinzhou Wang , Yimeng Wang , Ye Xiao , Liabette Escamilla , Bianca Augustine , Kelly Crace , Gang Zhou , Yixuan Zhang

Large language models (LLMs) have been used for diverse tasks in natural language processing (NLP), yet remain under-explored for task-oriented dialogue systems (TODS), especially for end-to-end TODS. We present InstructTODS, a novel…

Computation and Language · Computer Science 2023-10-16 Willy Chung , Samuel Cahyawijaya , Bryan Wilie , Holy Lovenia , Pascale Fung

Despite the plethora of telehealth applications to assist home-based older adults and healthcare providers, basic messaging and phone calls are still the most common communication methods, which suffer from limited availability, information…

Computation and Language · Computer Science 2024-02-06 Ziqi Yang , Xuhai Xu , Bingsheng Yao , Shao Zhang , Ethan Rogers , Stephen Intille , Nawar Shara , Guodong Gordon Gao , Dakuo Wang

Telephone surveys remain a valuable tool for gathering insights but typically require substantial resources in training and coordinating human interviewers. This work presents an AI-driven telephone survey system integrating text-to-speech…

Human-Computer Interaction · Computer Science 2025-03-13 Max M. Lang , Sol Eskenazi