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Proton pencil beam scanning (PBS) treatment planning for head & neck (H&N) cancers involves numerous conflicting objectives, requiring iterative objective parameter adjustments to balance multiple clinical goals. We propose a…

Artificial Intelligence · Computer Science 2025-09-16 Qingqing Wang , Liqiang Xiao , Chang Chang

Purpose: To evaluate automated multicriteria optimization (MCO)-- designed for intensity modulated radiation therapy (IMRT), but invoked with limited segmentation -- to efficiently produce high quality 3D conformal treatment (3D-CRT) plans.…

Medical Physics · Physics 2014-02-03 Fazal Khan , David Craft

In the design of a diffraction-limited storage ring (DLSR) consisting of compact multi-bend achromats (MBAs), it is challenging to simultaneously achieve an ultralow emittance and a satisfactory nonlinear performance, due to extremely large…

Accelerator Physics · Physics 2017-04-05 Y. Jiao , G. Xu

Purpose: Respiratory motion and the interplay effect cause the dose delivered to a patient with spot-scanned proton therapy to differ from the dose planned for during optimization. A new 4D robust optimization methodology was developed…

Radiation therapy (RT) aims to deliver tumoricidal doses with minimal radiation-induced normal-tissue toxicity. Compared to conventional RT (of conventional dose rate), FLASH-RT (of ultra-high dose rate) can provide additional normal tissue…

Optimization and Control · Mathematics 2023-11-27 Fengmiao Bian , Jiulong Liu , Xiaoqun Zhang , Hao Gao , Jian-Feng Cai

Radiation therapy treatment planning can be viewed as an iterative hyperparameter tuning process to balance conflicting clinical goals. In this work, we investigated the performance of modern Bayesian Optimization (BO) methods on automated…

Medical Physics · Physics 2023-02-15 Qingying Wang , Ruoxi Wang , Jiacheng Liu , Fan Jiang , Haizhen Yue , Yi Du , Hao Wu

This paper proposes a robust reduced-rank scheme for adaptive beamforming based on joint iterative optimization (JIO) of adaptive filters. The scheme provides an efficient way to deal with filters with large number of elements. It consists…

Information Theory · Computer Science 2013-03-18 Lei Wang , Rodrigo C. de Lamare

Laser-accelerated protons have a great potential for innovative experiments in radiation biology due to the sub-picosecond pulse duration and high dose rate achievable. However, the broad angular divergence makes them not optimal for…

Medical Physics · Physics 2019-11-13 Marco Cavallone , Alessandro Flacco , Victor Malka

In the past decades mathematical optimization has found its way into radiation therapy and has made profound practice changing impact. Today, virtually all advanced treatment delivery methods, such as IMRT, VMAT, tomotherapy, LDR/HDR…

Medical Physics · Physics 2018-10-31 Bram L. Gorissen , Jan Unkelbach , Thomas R. Bortfeld

Photons are exponentially attenuated in matter producing high doses close to the surface. Therefore they are not well suited for the treatment of deep seated tumours. Charged particles, in contrast, exhibit a sharp increase of ionisation…

Instrumentation and Detectors · Physics 2009-11-06 C. Grupen

In this paper, we investigate a movable antenna (MA) enabled anti-jamming optimization problem, where a legitimate uplink system is exposed to multiple jammers with unknown jamming channels. To enhance the anti-jamming capability of the…

Signal Processing · Electrical Eng. & Systems 2025-12-24 Lebin Chen , Ming-Min Zhao , Qingqing Wu , Min-Jian Zhao , Rui Zhang

Treatment planning in low-dose-rate prostate brachytherapy (LDR-PB) aims to produce arrangement of implantable radioactive seeds that deliver a minimum prescribed dose to the prostate whilst minimizing toxicity to healthy tissues. There can…

Computer Vision and Pattern Recognition · Computer Science 2022-05-10 Tajwar Abrar Aleef , Ingrid T. Spadinger , Michael D. Peacock , Septimiu E. Salcudean , S. Sara Mahdavi

Laser-driven proton sources have long been developed with an eye on their potential for medical application to radiation therapy. These sources are compact, versatile, and show peculiar characteristics such as extreme instantaneous dose…

We consider an optimization deployment problem of multistatic radar system (MSRS). Through the antenna placing and the transmitted power allocating, we optimally deploy the MSRS for two goals: 1) the first one is to improve the coverage…

Information Theory · Computer Science 2016-05-25 Yichuan Yang , Tianxian Zhang , Wei Yi , Lingjiang Kong , Xiaolong Li , Bing Wang , Xiaobo Yang

A novel linear blind adaptive receiver based on joint iterative optimization (JIO) and the constrained constant modulus (CCM) design criterion is proposed for interference suppression in direct-sequence ultra-wideband (DS-UWB) systems. The…

Information Theory · Computer Science 2013-05-15 Sheng Li , Rodrigo C. de Lamare

Purpose: To demonstrate the feasibility of fast Monte Carlo (MC) based inverse biological planning for the treatment of head and neck tumors in spot-scanning proton therapy. Methods: Recently, a fast and accurate Graphics Processor Unit…

Medical Physics · Physics 2016-10-11 H. Wan Chan Tseung , J. Ma , C. R. Kreofsky , D. Ma , C. Beltran

Objective: Radiation therapy treatment planning is a time-consuming, iterative process with potentially high inter-planner variability. Fully automated treatment planning processes could reduce a planner's active treatment planning time and…

Medical Physics · Physics 2021-02-09 Charles Huang , Yong Yang , Neil Panjwani , Stephen Boyd , Lei Xing

Pansharpening aims to generate a high spatial resolution multispectral image (HRMS) by fusing a low spatial resolution multispectral image (LRMS) and a panchromatic image (PAN). The most challenging issue for this task is that only the…

Image and Video Processing · Electrical Eng. & Systems 2024-11-08 Xiangyu Rui , Xiangyong Cao , Yining Li , Deyu Meng

We consider joint beamforming and stream allocation to maximize the weighted sum rate (WSR) for non-coherent joint transmission (NCJT) in user-centric cell-free MIMO networks, where distributed access points (APs) are organized in clusters…

Signal Processing · Electrical Eng. & Systems 2024-02-29 Xi Wang , Xiaotong Zhao , Juncheng Wang , You Li , Qingjiang Shi

Uncertainties such as setup and range errors can significantly compromise proton therapy. A discrete uncertainty set is often constructed to represent different uncertainty scenarios. A min-max robust optimization approach is then utilized…

Optimization and Control · Mathematics 2025-08-12 Zihang Qiu , Ali Ajdari , Mislav Bobić , Thomas Bortfeld , Dick den Hertog , Jannis Kurtz , Hoyeon Lee
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