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Optoacoustic tomography (OAT), also known as photoacoustic tomography, is a rapidly emerging hybrid imaging technique that possesses great potential for a wide range of biomedical imaging applications. In OAT, a laser is employed to…

Medical Physics · Physics 2016-12-21 Yang Lou , Kun Wang , Alexander. A. Oraevsky , Mark. A. Anastasio

Holographic optical coherence tomography (OCT) is a powerful imaging technique, but its ability to reveal low-reflectivity features is limited. In this study, we performed holographic OCT by incoherently averaging volumes with changing…

Our interest has been to study the effect that scattered radiation has on contrast, signal-to-noise ratio and thickness reconstruction in digital mammographies. Using the GEANT code we have performed Monte-Carlo simulations of 25 kVp Mo/Mo…

Medical Physics · Physics 2009-09-29 Varlen Grabski , Maria-Ester Brandan

Many naturally-occuring models in the sciences are well-approximated by simplified models, using multiscale techniques. In such settings it is natural to ask about the relationship between inverse problems defined by the original problem…

Numerical Analysis · Mathematics 2019-02-28 Kit Newton , Qin Li , Andrew Stuart

Optical diffraction tomography (ODT) enables non-invasive information-rich 3D refractive index (RI) reconstruction of unimpaired transparent biological and technical samples, crucial in biomedical research, optical metrology, materials…

Random scattering of light in disordered media is an intriguing phenomenon of fundamental relevance to various applications. While techniques such as wavefront shaping and transmission matrix measurements have enabled remarkable progress…

Grazing incidence x-ray scattering provides nanostructural information for thin film samples, but single images generally do not provide information on film thickness or the full complex index of refraction. Additionally, for thin films…

Applied Physics · Physics 2020-11-10 Peter J. Dudenas , Adam Z. Weber , Ahmet Kusoglu

Over the past decade, optical wavefront shaping has been developed to focus light through highly opaque scattering layers, opening new possibilities for biomedical applications. To probe light intensity deep inside soft scattering media…

Optics · Physics 2025-08-25 Fei Xia , Ivo Leite , Robert Prevedel , Thomas Chaigne

Scattering and absorption limit the penetration of optical fields into tissue, but wavefront correction, often used to compensate for these effects, is incompatible with wide field-of-view imaging and complex to implement. We demonstrate a…

We present a new formalism for understanding the optical properties of metasurfaces, optically thin composite diffractive devices. The proposed technique, Rigorous Diffraction Interface Theory (R-DIT), provides an analytical framework for…

Optics · Physics 2017-05-24 Christopher M. Roberts , Viktor A Podolskiy

Imaging depth of optical microscopy has been fundamentally limited to millimeter or sub-millimeter due to light scattering. X-ray microscopy can resolve spatial details of few microns deeply inside a sample but the contrast resolution is…

Biological Physics · Physics 2015-06-17 Wenxiang Cong , Fenglin Liu , Chao Wang , Ge Wang

An efficient and accurate image reconstruction algorithm for ultrasound tomography (UST) is described and demonstrated, which can recover accurate sound speed distribution from acoustic time series measurements made in soft tissue. The…

Numerical Analysis · Mathematics 2021-11-17 Ashkan Javaherian , Ben Cox

Induced transparency is a common but remarkable effect in optics. It occurs when a strong driving field is used to render an otherwise opaque material transparent. The effect is known as electromagnetically induced transparency in atomic…

Advancement in mid-infrared (MIR) technology has led to promising biomedical applications of MIR spectroscopy, such as liquid biopsy or breath diagnosis. On the contrary, MIR microscopy has been rarely used for live biological samples in an…

Light scattering by tissue severely limits how deep beneath the surface one can image, and the spatial resolution one can obtain from these images. Diffuse optical tomography (DOT) is one of the most powerful techniques for imaging deep…

Image and Video Processing · Electrical Eng. & Systems 2021-05-31 Yongyi Zhao , Ankit Raghuram , Hyun K. Kim , Andreas H. Hielscher , Jacob T. Robinson , Ashok Veeraraghavan

Optical imaging relies on the ability to illuminate an object, collect and analyze the light it scatters or transmits. Propagation through complex media such as biological tissues was so far believed to degrade the attainable depth as well…

Optics · Physics 2010-09-24 S. M. Popoff , G. Lerosey , M. Fink , A. C. Boccara , S. Gigan

We introduce a phase imaging mechanism for scanning transmission electron microscopy that exploits the complementary intensity changes of transmitted disks at different scattering angles. For scanning transmission electron microscopy, this…

Instrumentation and Detectors · Physics 2023-07-06 Binbin Wang , David W. McComb

Fluorescence microscopy is widely used in biological imaging, however scattering from tissues strongly limits its applicability to a shallow depth. In this work we adapt a methodology inspired from stellar speckle interferometry, and…

Transmission optical coherence tomography (OCT) enables analysis of biological specimens in vitro through detection of forward scattered light. Up to now, transmission OCT was considered as a technique that cannot directly retrieve…

Optics · Physics 2024-05-24 Wojciech Krauze , Martyna Mazur , Arkadiusz Kuś

Quantum imaging can potentially provide certain advantages over classical imaging. Thus far, however, the signal-to-noise ratios (SNRs) are poor; the resolvable pixel counts are low; biological organisms have not been imaged; birefringence…

Quantum Physics · Physics 2024-03-13 Yide Zhang , Zhe He , Xin Tong , David C. Garrett , Rui Cao , Lihong V. Wang
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