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With increased interest in adopting AI methods for clinical diagnosis, a vital step towards safe deployment of such tools is to ensure that the models not only produce accurate predictions but also do not generalize to data regimes where…

Machine Learning · Computer Science 2021-03-08 Vivek Narayanaswamy , Jayaraman J. Thiagarajan , Deepta Rajan , Andreas Spanias

In this article, we propose a novel regularization method for a class of nonlinear inverse problems that is inspired by an application in quantitative magnetic resonance imaging (qMRI). The latter is a special instance of a general…

Optimization and Control · Mathematics 2025-06-16 Guozhi Dong , Michael Hintermüller , Clemens Sirotenko

Stain variations often decrease the generalization ability of deep learning based approaches in digital histopathology analysis. Two separate proposals, namely stain normalization (SN) and stain augmentation (SA), have been spotlighted to…

Computer Vision and Pattern Recognition · Computer Science 2023-03-03 Yiqing Shen , Yulin Luo , Dinggang Shen , Jing Ke

Domain shift is a significant problem in histopathology. There can be large differences in data characteristics of whole-slide images between medical centers and scanners, making generalization of deep learning to unseen data difficult. To…

Computer Vision and Pattern Recognition · Computer Science 2019-09-27 Karin Stacke , Gabriel Eilertsen , Jonas Unger , Claes Lundström

As artificial intelligence and digital medicine increasingly permeate healthcare systems, robust governance frameworks are essential to ensure ethical, secure, and effective implementation. In this context, medical image retrieval becomes a…

Computer Vision and Pattern Recognition · Computer Science 2025-06-30 Yang Nan , Huichi Zhou , Xiaodan Xing , Giorgos Papanastasiou , Lei Zhu , Zhifan Gao , Alejandro F Fangi , Guang Yang

A survival analysis model for predicting time-to-total knee replacement (TKR) was developed using features from medical images and clinical measurements. Supervised and self-supervised deep learning approaches were utilized to extract…

Image and Video Processing · Electrical Eng. & Systems 2024-11-19 Ozkan Cigdem , Shengjia Chen , Chaojie Zhang , Kyunghyun Cho , Richard Kijowski , Cem M. Deniz

Machine learning models trained with \emph{stochastic} gradient descent (SGD) can generalize better than those trained with deterministic gradient descent (GD). In this work, we study SGD's impact on generalization through the lens of the…

Machine Learning · Computer Science 2025-12-09 Hongjian Lan , Yucong Liu , Florian Schäfer

Long-term vertebral fractures severely affect the life quality of patients, causing kyphotic, lumbar deformity and even paralysis. Computed tomography (CT) is a common clinical examination to screen for this disease at early stages.…

Computer Vision and Pattern Recognition · Computer Science 2022-11-14 Xin Wei , Huaiwei Cong , Zheng Zhang , Junran Peng , Guoping Chen , Jinpeng Li

Histopathological images are essential for medical diagnosis and treatment planning, but interpreting them accurately using machine learning can be challenging due to variations in tissue preparation, staining and imaging protocols. Domain…

Computer Vision and Pattern Recognition · Computer Science 2023-11-01 Vaibhav Khamankar , Sutanu Bera , Saumik Bhattacharya , Debashis Sen , Prabir Kumar Biswas

A Magnetic Resonance Imaging (MRI) exam typically consists of the acquisition of multiple MR pulse sequences, which are required for a reliable diagnosis. Each sequence can be parameterized through multiple acquisition parameters affecting…

Image and Video Processing · Electrical Eng. & Systems 2022-02-23 Jonas Denck , Jens Guehring , Andreas Maier , Eva Rothgang

Background: Osteoporosis and osteopenia are often undiagnosed until fragility fractures occur. Dual-energy X-ray absorptiometry (DXA) is the reference standard for bone mineral density (BMD) assessment, but access remains limited. Knee…

Computer Vision and Pattern Recognition · Computer Science 2026-04-23 Zhaochen Li , Xinghao Yan , Runni Zhou , Xiaoyang Li , Chenjie Zhu , Gege Wang , Yu Shi , Lixin Zhang , Rongrong Fu , Liehao Yan , Yuan Chai

The severity of knee osteoarthritis is graded using the 5-point Kellgren-Lawrence (KL) scale where healthy knees are assigned grade 0, and the subsequent grades 1-4 represent increasing severity of the affliction. Although several methods…

Image and Video Processing · Electrical Eng. & Systems 2020-04-21 Sudeep Kondal , Viraj Kulkarni , Ashrika Gaikwad , Amit Kharat , Aniruddha Pant

The generalization with respect to domain shifts, as they frequently appear in applications such as autonomous driving, is one of the remaining big challenges for deep learning models. Therefore, we propose an intra-source style…

Computer Vision and Pattern Recognition · Computer Science 2023-05-30 Yumeng Li , Dan Zhang , Margret Keuper , Anna Khoreva

Image normalization, the correction for intra-volume inhomogeneities in magnetic resonance imaging (MRI) data has little significance for visual diagnosis, but is a crucial step before automated radiotherapy solutions. There are several…

Image and Video Processing · Electrical Eng. & Systems 2019-09-13 A. Simkó , T. Löfstedt , A. Garpebring , T. Nyholm , J. Jonsson

The clinical deployment of deep learning models in medical imaging is severely hindered by domain shift. This challenge, where a high-performing model fails catastrophically on external datasets, is a critical barrier to trustworthy AI.…

Computer Vision and Pattern Recognition · Computer Science 2025-12-17 Youssef Abuzeid , Shimaa El-Bana , Ahmad Al-Kabbany

This study evaluated generative methods to potentially mitigate AI bias when diagnosing diabetic retinopathy (DR) resulting from training data imbalance, or domain generalization which occurs when deep learning systems (DLS) face concepts…

Artificial Intelligence · Computer Science 2020-12-03 Philippe Burlina , Neil Joshi , William Paul , Katia D. Pacheco , Neil M. Bressler

Background: Deep learning models are typically trained using stochastic gradient descent or one of its variants. These methods update the weights using their gradient, estimated from a small fraction of the training data. It has been…

Machine Learning · Statistics 2018-01-03 Elad Hoffer , Itay Hubara , Daniel Soudry

Utilizing recently introduced concepts from statistics and quantitative risk management, we present a general variant of Batch Normalization (BN) that offers accelerated convergence of Neural Network training compared to conventional BN. In…

Machine Learning · Computer Science 2018-12-11 Xiaoyong Yuan , Zheng Feng , Matthew Norton , Xiaolin Li

Deep learning algorithms utilizing magnetic resonance (MR) images have demonstrated cutting-edge proficiency in autonomously segmenting multiple sclerosis (MS) lesions. Despite their achievements, these algorithms may struggle to extend…

Image and Video Processing · Electrical Eng. & Systems 2023-11-01 Jinwei Zhang , Lianrui Zuo , Blake E. Dewey , Samuel W. Remedios , Savannah P. Hays , Dzung L. Pham , Jerry L. Prince , Aaron Carass

Learning robust vision models that perform well in out-of-distribution (OOD) situations is an important task for model deployment in real-world settings. Despite extensive research in this field, many proposed methods have only shown minor…

Computer Vision and Pattern Recognition · Computer Science 2024-12-10 Gyuseong Lee , Wooseok Jang , Jinhyeon Kim , Jaewoo Jung , Seungryong Kim