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Automatic clinical diagnosis of retinal diseases has emerged as a promising approach to facilitate discovery in areas with limited access to specialists. Based on the fact that fundus structure and vascular disorders are the main…

Computer Vision and Pattern Recognition · Computer Science 2018-11-05 C. -H. Huck Yang , Fangyu Liu , Jia-Hong Huang , Meng Tian , Hiromasa Morikawa , I-Hung Lin , Yi-Chieh Liu , Hao-Hsiang Yang , Jesper Tegner

In the rapidly evolving field of optical engineering, precise alignment of multi-lens imaging systems is critical yet challenging, as even minor misalignments can significantly degrade performance. Traditional alignment methods rely on…

Optics · Physics 2025-07-01 Tomer Slor , Dean Oren , Shira Baneth , Tom Coen , Haim Suchowski

Choroidal nevi are common benign pigmented lesions in the eye, with a small risk of transforming into melanoma. Early detection is critical to improving survival rates, but misdiagnosis or delayed diagnosis can lead to poor outcomes.…

Computer Vision and Pattern Recognition · Computer Science 2026-04-16 Mohammadmahdi Eshragh , Emad A. Mohammed , Behrouz Far , Ezekiel Weis , Carol L Shields , Sandor R Ferenczy , Trafford Crump

High myopia significantly increases the risk of irreversible vision loss. Traditional perimetry-based visual field (VF) assessment provides systematic quantification of visual loss but it is subjective and time-consuming. Consequently,…

Computer Vision and Pattern Recognition · Computer Science 2024-07-18 Zipei Yan , Zhile Liang , Zhengji Liu , Shuai Wang , Rachel Ka-Man Chun , Jizhou Li , Chea-su Kee , Dong Liang

This investigation reports on the results of convolutional neural networks developed for the recently introduced PathologicAL Myopia (PALM) dataset, which consists of 1200 fundus images. We propose a new Optic Nerve Head (ONH)-based…

Image and Video Processing · Electrical Eng. & Systems 2020-06-05 Ruben Hemelings , Bart Elen , Matthew B. Blaschko , Julie Jacob , Ingeborg Stalmans , Patrick De Boever

Diffractive lenses have recently been applied to the domain of multispectral imaging in the X-ray and UV regimes where they can achieve very high resolution as compared to reflective and refractive optics. Conventionally, spectral…

Image and Video Processing · Electrical Eng. & Systems 2020-05-26 Evan Widloski , Ulas Kamaci , Farzad Kamalabadi

Our research is motivated by the urgent global issue of a large population affected by retinal diseases, which are evenly distributed but underserved by specialized medical expertise, particularly in non-urban areas. Our primary objective…

Computer Vision and Pattern Recognition · Computer Science 2025-03-28 Deependra Singh , Saksham Agarwal , Subhankar Mishra

Automated segmentation of the optic cup and disk on retinal fundus images is fundamental for the automated detection / analysis of glaucoma. Traditional segmentation approaches depend heavily upon hand-crafted features and a priori…

Computer Vision and Pattern Recognition · Computer Science 2019-02-14 Lei Bi , Yuyu Guo , Qian Wang , Dagan Feng , Michael Fulham , Jinman Kim

Machine learning is gaining significant attention as a diagnostic tool in medical imaging, particularly in the analysis of retinal fundus images. However, this approach is not yet clinically applicable, as it still depends on human…

Human-Computer Interaction · Computer Science 2025-10-03 Mattea Reid , Zuhairah Zainal , Khaing Zin Than , Danielle Chan , Jonathan Chan

Retinal diseases can cause irreversible vision loss in both eyes if not diagnosed and treated early. Since retinal diseases are so complicated, retinal imaging is likely to show two or more abnormalities. Current deep learning techniques…

Image and Video Processing · Electrical Eng. & Systems 2024-07-04 Tariq M Khan , Shahzaib Iqbal , Syed S. Naqvi , Imran Razzak , Erik Meijering

Optic disc (OD) and optic cup (OC) are regions of prominent clinical interest in a retinal fundus image. They are the primary indicators of a glaucomatous condition. With the advent and success of deep learning for healthcare research,…

Image and Video Processing · Electrical Eng. & Systems 2020-12-15 Aniketh Manjunath , Subramanya Jois , Chandra Sekhar Seelamantula

Deep learning models have gained increasing adoption in medical image analysis. However, these models often produce overconfident predictions, which can compromise clinical accuracy and reliability. Bridging the gap between high-performance…

Image and Video Processing · Electrical Eng. & Systems 2026-03-24 Jutika Borah , Hidam Kumarjit Singh

The acquisition of high-resolution retinal fundus images with a large field of view (FOV) is challenging due to technological, physiological and economic reasons. This paper proposes a fully automatic framework to reconstruct retinal images…

Computer Vision and Pattern Recognition · Computer Science 2016-02-11 Thomas Köhler , Axel Heinrich , Andreas Maier , Joachim Hornegger , Ralf P. Tornow

Dual-comb microscopy (DCM), an interesting imaging modality based on the optical-frequency-comb (OFC) mode and image pixel one-to-one correspondence, benefits from scan-less full-field imaging and simultaneous confocal amplitude and phase…

Diabetic retinopathy (DR) results in vision loss if not treated early. A computer-aided diagnosis (CAD) system based on retinal fundus images is an efficient and effective method for early DR diagnosis and assisting experts. A…

Computer Vision and Pattern Recognition · Computer Science 2019-08-23 Norah Asiri , Muhammad Hussain , Fadwa Al Adel , Nazih Alzaidi

Object detection in poor-illumination environments is a challenging task as objects are usually not clearly visible in RGB images. As infrared images provide additional clear edge information that complements RGB images, fusing RGB and…

Computer Vision and Pattern Recognition · Computer Science 2024-12-09 Yishuo Chen , Boran Wang , Xinyu Guo , Wenbin Zhu , Jiasheng He , Xiaobin Liu , Jing Yuan

In this paper we give a brief review on the present status of automated detection systems describe for the screening of diabetic retinopathy. We further detail an enhanced detection procedure that consists of two steps. First, a…

Computer Vision and Pattern Recognition · Computer Science 2014-11-04 Balint Antal , Andras Hajdu , Zsuzsanna Maros-Szabo , Zsolt Torok , Adrienne Csutak , Tunde Peto

This paper presents Deep Retinal Image Understanding (DRIU), a unified framework of retinal image analysis that provides both retinal vessel and optic disc segmentation. We make use of deep Convolutional Neural Networks (CNNs), which have…

Computer Vision and Pattern Recognition · Computer Science 2016-11-17 Kevis-Kokitsi Maninis , Jordi Pont-Tuset , Pablo Arbeláez , Luc Van Gool

In this manuscript, we present a robust method for glaucoma screening from fundus images using an ensemble of convolutional neural networks (CNNs). The pipeline comprises of first segmenting the optic disk and optic cup from the fundus…

Computer Vision and Pattern Recognition · Computer Science 2018-09-17 Vismay Agrawal , Avinash Kori , Varghese Alex , Ganapathy Krishnamurthi

Glaucoma is a chronic eye disease that leads to irreversible vision loss. Most of the existing automatic screening methods firstly segment the main structure, and subsequently calculate the clinical measurement for detection and screening…

Computer Vision and Pattern Recognition · Computer Science 2018-05-22 Huazhu Fu , Jun Cheng , Yanwu Xu , Changqing Zhang , Damon Wing Kee Wong , Jiang Liu , Xiaochun Cao