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Data sharing is a necessity for innovative progress in many domains, especially in healthcare. However, the ability to share data is hindered by regulations protecting the privacy of natural persons. Synthetic tabular data provide a…

Machine Learning · Computer Science 2025-07-17 Tobias Hyrup , Anton Danholt Lautrup , Arthur Zimek , Peter Schneider-Kamp

Recent advances in generative models facilitate the creation of synthetic data to be made available for research in privacy-sensitive contexts. However, the analysis of synthetic data raises a unique set of methodological challenges. In…

Access to large-scale high-quality healthcare databases is key to accelerate medical research and make insightful discoveries about diseases. However, access to such data is often limited by patient privacy concerns, data sharing…

This article provides a comprehensive synthesis of the recent developments in synthetic data generation via deep generative models, focusing on tabular datasets. We specifically outline the importance of synthetic data generation in the…

Machine Learning · Computer Science 2023-08-29 Conor Hassan , Robert Salomone , Kerrie Mengersen

Many ground-breaking advancements in machine learning can be attributed to the availability of a large volume of rich data. Unfortunately, many large-scale datasets are highly sensitive, such as healthcare data, and are not widely available…

Machine Learning · Computer Science 2020-12-09 James Jordon , Alan Wilson , Mihaela van der Schaar

Synthetic data generation using large language models (LLMs) demonstrates substantial promise in addressing biomedical data challenges and shows increasing adoption in biomedical research. This study systematically reviews recent advances…

Computation and Language · Computer Science 2026-02-18 Hanshu Rao , Weisi Liu , Haohan Wang , I-Chan Huang , Zhe He , Xiaolei Huang

Accurately evaluating model performance is crucial for deploying machine learning systems in real-world applications. Traditional methods often require a sufficiently large labeled test set to ensure a reliable evaluation. However, in many…

Machine Learning · Computer Science 2025-11-04 Hai Hoang Thanh , Duy-Tung Nguyen , Hung The Tran , Khoat Than

Systematic literature reviews play a vital role in identifying the best available evidence for health and social care policy. The resources required to produce systematic reviews can be significant, and a key to the success of any review is…

Information Retrieval · Computer Science 2021-12-20 Andrew MacFarlane , Tony Russell-Rose , Farhad Shokraneh

Background: High-level system testing of applications that use data from e-Government services as input requires test data that is real-life-like but where the privacy of personal information is guaranteed. Applications with such strong…

Machine Learning · Computer Science 2026-02-09 Maj-Annika Tammisto , Faiz Ali Shah , Daniel Rodriguez , Dietmar Pfahl

This paper presents a comprehensive systematic review of generative models (GANs, VAEs, DMs, and LLMs) used to synthesize various medical data types, including imaging (dermoscopic, mammographic, ultrasound, CT, MRI, and X-ray), text,…

Tabular synthesis models remain ineffective at capturing complex dependencies, and the quality of synthetic data is still insufficient for comprehensive downstream tasks, such as prediction under distribution shifts, automated…

Machine Learning · Computer Science 2024-07-08 Ruibo Tu , Zineb Senane , Lele Cao , Cheng Zhang , Hedvig Kjellström , Gustav Eje Henter

Dependencies among attributes are a common aspect of tabular data. However, whether existing tabular data generation algorithms preserve these dependencies while generating synthetic data is yet to be explored. In addition to the existing…

Machine Learning · Computer Science 2024-09-27 Chaithra Umesh , Kristian Schultz , Manjunath Mahendra , Saparshi Bej , Olaf Wolkenhauer

Synthetic tabular data generation has emerged as a promising method to address limited data availability and privacy concerns. With the sharp increase in the performance of large language models in recent years, researchers have been…

Machine Learning · Computer Science 2025-03-28 Reilly Cannon , Nicolette M. Laird , Caesar Vazquez , Andy Lin , Amy Wagler , Tony Chiang

Generating clinical synthetic text represents an effective solution for common clinical NLP issues like sparsity and privacy. This paper aims to conduct a systematic review on generating synthetic medical free-text by formulating…

Computation and Language · Computer Science 2025-07-25 Basel Alshaikhdeeb , Ahmed Abdelmonem Hemedan , Soumyabrata Ghosh , Irina Balaur , Venkata Satagopam

Multimodal data modeling has emerged as a powerful approach in clinical research, enabling the integration of diverse data types such as imaging, genomics, wearable sensors, and electronic health records. Despite its potential to improve…

Synthetic data is widely used in healthcare to create datasets that are similar to original data but without the privacy concerns. Generating and evaluating synthetic data across privacy, utility and fairness is crucial for facilitating…

Synthetic data generation is a powerful tool for privacy protection when considering public release of record-level data files. Initially proposed about three decades ago, it has generated significant research and application interest. To…

Methodology · Statistics 2023-08-03 Jingchen Hu , Claire McKay Bowen

Synthetic data generation has been widely adopted in software testing, data privacy, imbalanced learning, and artificial intelligence explanation. In all such contexts, it is crucial to generate plausible data samples. A common assumption…

Artificial Intelligence · Computer Science 2024-10-16 Martina Cinquini , Fosca Giannotti , Riccardo Guidotti

Synthetic data has gained significant momentum thanks to sophisticated machine learning tools that enable the synthesis of high-dimensional datasets. However, many generation techniques do not give the data controller control over what…

Cryptography and Security · Computer Science 2022-11-22 Florimond Houssiau , Samuel N. Cohen , Lukasz Szpruch , Owen Daniel , Michaela G. Lawrence , Robin Mitra , Henry Wilde , Callum Mole

In the rapidly evolving field of artificial intelligence, the creation and utilization of synthetic datasets have become increasingly significant. This report delves into the multifaceted aspects of synthetic data, particularly emphasizing…

Machine Learning · Computer Science 2024-01-04 Shuang Hao , Wenfeng Han , Tao Jiang , Yiping Li , Haonan Wu , Chunlin Zhong , Zhangjun Zhou , He Tang