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Identification of tumor margins is essential for surgical decision-making for glioblastoma patients and provides reliable assistance for neurosurgeons. Despite improvements in deep learning architectures for tumor segmentation over the…

Accurate segmentation of gastrointestinal (GI) organs in magnetic resonance enterography (MRE) is critical for diagnosing inflammatory bowel disease (IBD). However, anatomical variability, class imbalance, and low tissue contrast hinder…

Drug-target interaction (DTI) prediction is crucial for drug development and repositioning. Methods using heterogeneous graph neural networks (HGNNs) for DTI prediction have become a promising approach, with attention-based models often…

This industrial Ph.D. project, carried out in collaboration between Radiometer Medical ApS and SDU Centre for Photonics Engineering at the University of Southern Denmark, explored the use of digital holographic microscopy (DHM) for the…

Diabetic retinopathy (DR) is a complication of diabetes that severely affects eyes. It can be graded into five levels of severity according to international protocol. However, optimizing a grading model to have strong generalizability…

\textit{Objective:} Gadolinium-based contrast agents (GBCAs) have been widely used to better visualize disease in brain magnetic resonance imaging (MRI). However, gadolinium deposition within the brain and body has raised safety concerns…

Pancreatic ductal adenocarcinoma (PDAC) presents a critical global health challenge, and early detection is crucial for improving the 5-year survival rate. Recent medical imaging and computational algorithm advances offer potential…

To obtain high-quality positron emission tomography (PET) scans while reducing radiation exposure to the human body, various approaches have been proposed to reconstruct standard-dose PET (SPET) images from low-dose PET (LPET) images. One…

Dynamic Contrast-enhanced Magnetic Resonance Imaging (DCE-MRI) is an important tool for detecting subtle kinetic changes in cancerous tissue. Quantitative analysis of DCE-MRI typically involves the convolution of an arterial input function…

Nuclei segmentation is a fundamental task that is critical for various computational pathology applications including nuclei morphology analysis, cell type classification, and cancer grading. Conventional vision-based methods for nuclei…

Medical image synthesis generates additional imaging modalities that are costly, invasive or harmful to acquire, which helps to facilitate the clinical workflow. When training pairs are substantially misaligned (e.g., lung MRI-CT pairs with…

Magnetic resonance imaging (MRI) is the most sensitive technique for breast cancer detection among current clinical imaging modalities. Contrast-enhanced MRI (CE-MRI) provides superior differentiation between tumors and invaded healthy…

Dynamic Contrast Enhanced Magnetic Resonance Imaging aids in the detection and assessment of tumor aggressiveness by using a Gadolinium-based contrast agent (GBCA). However, GBCA is known to have potential toxic effects. This risk can be…

LDCT has drawn major attention in the medical imaging field due to the potential health risks of CT-associated X-ray radiation to patients. Reducing the radiation dose, however, decreases the quality of the reconstructed images, which…

Deep learning (DL) methods have been extensively applied to various image recovery problems, including magnetic resonance imaging (MRI) and computed tomography (CT) reconstruction. Beyond supervised models, other approaches have been…

The quality of images captured by wireless capsule endoscopy (WCE) is key for doctors to diagnose diseases of gastrointestinal (GI) tract. However, there exist many low-quality endoscopic images due to the limited illumination and complex…

Although efficient extraction of discriminative spatial-spectral features is critical for hyperspectral images classification (HSIC), it is difficult to achieve these features due to factors such as the spatial-spectral heterogeneity and…

Segmentation of bone regions allows for enhanced diagnostics, disease characterisation and treatment monitoring in CT imaging. In contrast enhanced whole-body scans accurate automatic segmentation is particularly difficult as low dose whole…

An optical microscopic examination of thinly cut stained tissue on glass slides prepared from a FFPE tissue blocks is the gold standard for tissue diagnostics. In addition, the diagnostic abilities and expertise of any pathologist is…

Automated blood vessel segmentation is vital for biomedical imaging, as vessel changes indicate many pathologies. Still, precise segmentation is difficult due to the complexity of vascular structures, anatomical variations across patients,…