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Generative models based on variational autoencoders are a popular technique for detecting anomalies in images in a semi-supervised context. A common approach employs the anomaly score to detect the presence of anomalies, and it is known to…

Machine Learning · Computer Science 2024-07-30 Muhammad Rashid , Elvio Amparore , Enrico Ferrari , Damiano Verda

Learning a robust Variational Autoencoder (VAE) is a fundamental step for many deep learning applications in medical image analysis, such as MRI synthesizes. Existing brain VAEs predominantly focus on single-modality data (i.e., T1-weighted…

Computer Vision and Pattern Recognition · Computer Science 2026-04-08 Mingjie Li , Edward Kim , Yue Zhao , Ehsan Adeli , Kilian M. Pohl

This paper aims to develop an acoustic signal-based unsupervised anomaly detection method for automatic machine monitoring. Existing approaches such as deep autoencoder (DAE), variational autoencoder (VAE), conditional variational…

Machine Learning · Computer Science 2022-06-14 Harsh Purohit , Takashi Endo , Masaaki Yamamoto , Yohei Kawaguchi

Confounding pathology with normal anatomical variation remains a significant challenge in unsupervised medical-image anomaly detection, resulting in numerous false positives. To enhance integration of healthy variation, we augment the…

Quantitative Methods · Quantitative Biology 2026-03-09 P. Bilha Githinji , Xi Yuan , Ijaz Gul , Lian Zhang , Jinhao Xu , Zhenglin Chen , Peiwu Qin , Dongmei Yu

We propose a variational autoencoder (VAE) approach for parameter estimation in nonlinear mixed-effects models based on ordinary differential equations (NLME-ODEs) using longitudinal data from multiple subjects. In moderate dimensions,…

Methodology · Statistics 2026-02-11 Zhe Li , Mélanie Prague , Rodolphe Thiébaut , Quentin Clairon

This paper addresses the challenges of detecting anomalies in cellular networks in an interpretable way and proposes a new approach using variational autoencoders (VAEs) that learn interpretable representations of the latent space for each…

Machine Learning · Computer Science 2023-06-29 Amandeep Singh , Michael Weber , Markus Lange-Hegermann

Quantitative imaging methods, such as magnetic resonance fingerprinting (MRF), aim to extract interpretable pathology biomarkers by estimating biophysical tissue parameters from signal evolutions. However, the pattern-matching algorithms or…

The detection of anomalous executions is valuable for reducing potential hazards in assistive manipulation. Multimodal sensory signals can be helpful for detecting a wide range of anomalies. However, the fusion of high-dimensional and…

Robotics · Computer Science 2017-11-03 Daehyung Park , Yuuna Hoshi , Charles C. Kemp

Inverse problems aim to determine model parameters of a mathematical problem from given observational data. Neural networks can provide an efficient tool to solve these problems. In the context of Bayesian inverse problems, Uncertainty…

Numerical Analysis · Mathematics 2025-09-16 Andrea Tonini , Tan Bui-Thanh , Francesco Regazzoni , Luca Dede' , Alfio Quarteroni

Anomaly detection in medical imaging is a challenging task in contexts where abnormalities are not annotated. This problem can be addressed through unsupervised anomaly detection (UAD) methods, which identify features that do not match with…

Image and Video Processing · Electrical Eng. & Systems 2023-09-07 Geoffroy Oudoumanessah , Carole Lartizien , Michel Dojat , Florence Forbes

Anomaly detection in supercomputers is a very difficult problem due to the big scale of the systems and the high number of components. The current state of the art for automated anomaly detection employs Machine Learning methods or…

Machine Learning · Computer Science 2020-07-30 Andrea Borghesi , Andrea Bartolini , Michele Lombardi , Michela Milano , Luca Benini

In recent years, the field of machine learning has made phenomenal progress in the pursuit of simulating real-world data generation processes. One notable example of such success is the variational autoencoder (VAE). In this work, with a…

Machine Learning · Statistics 2021-12-30 Hwan Goh , Sheroze Sheriffdeen , Jonathan Wittmer , Tan Bui-Thanh

Deep learning motivated by convolutional neural networks has been highly successful in a range of medical imaging problems like image classification, image segmentation, image synthesis etc. However for validation and interpretability, not…

Image and Video Processing · Electrical Eng. & Systems 2024-08-19 Abhinav Sagar

In medical applications, weakly supervised anomaly detection methods are of great interest, as only image-level annotations are required for training. Current anomaly detection methods mainly rely on generative adversarial networks or…

Image and Video Processing · Electrical Eng. & Systems 2022-10-06 Julia Wolleb , Florentin Bieder , Robin Sandkühler , Philippe C. Cattin

Recently Autoencoder(AE) based models are widely used in the field of anomaly detection. A model trained with normal data generates a larger restoration error for abnormal data. Whether or not abnormal data is determined by observing the…

Machine Learning · Computer Science 2021-07-20 JoonSung Lee , YeongHyeon Park

Time-of-Flight Magnetic Resonance Angiographs (TOF-MRAs) enable visualization and analysis of cerebral arteries. This analysis may indicate normal variation of the configuration of the cerebrovascular system or vessel abnormalities, such as…

Image and Video Processing · Electrical Eng. & Systems 2021-02-24 Kimberley M. Timmins , Irene C. van der Schaaf , Ynte M. Ruigrok , Birgitta K. Velthuis , Hugo J. Kuijf

In the contemporary digital landscape, the continuous generation of extensive streaming data across diverse domains has become pervasive. Yet, a significant portion of this data remains unlabeled, posing a challenge in identifying…

Computational Engineering, Finance, and Science · Computer Science 2025-08-25 Jin Li , Kleanthis Malialis , Christos G. Panayiotou , Marios M. Polycarpou

Medical images are often used to detect and characterize pathology and disease; however, automatically identifying and segmenting pathology in medical images is challenging because the appearance of pathology across diseases varies widely.…

Image and Video Processing · Electrical Eng. & Systems 2020-02-19 Jacob C. Reinhold , Yufan He , Shizhong Han , Yunqiang Chen , Dashan Gao , Junghoon Lee , Jerry L. Prince , Aaron Carass

Unsupervised anomaly detection is a challenging task. Autoencoders (AEs) or generative models are often employed to model the data distribution of normal inputs and subsequently identify anomalous, out-of-distribution inputs by high…

Machine Learning · Computer Science 2025-06-12 Yalin Liao , Austin J. Brockmeier

Despite advances in deep learning for estimating brain age from structural MRI data, incorporating functional MRI data is challenging due to its complex structure and the noisy nature of functional connectivity measurements. To address…

Computer Vision and Pattern Recognition · Computer Science 2024-11-18 Muhammad Usman , Azka Rehman , Abdullah Shahid , Abd Ur Rehman , Sung-Min Gho , Aleum Lee , Tariq M. Khan , Imran Razzak