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Deep unsupervised representation learning has recently led to new approaches in the field of Unsupervised Anomaly Detection (UAD) in brain MRI. The main principle behind these works is to learn a model of normal anatomy by learning to…

Image and Video Processing · Electrical Eng. & Systems 2020-04-09 Christoph Baur , Stefan Denner , Benedikt Wiestler , Shadi Albarqouni , Nassir Navab

The increasing complexity of medical imaging data underscores the need for advanced anomaly detection methods to automatically identify diverse pathologies. Current methods face challenges in capturing the broad spectrum of anomalies, often…

Image and Video Processing · Electrical Eng. & Systems 2024-01-22 Cosmin I. Bercea , Benedikt Wiestler , Daniel Rueckert , Julia A. Schnabel

Anomalies are by definition rare, thus labeled examples are very limited or nonexistent, and likely do not cover unforeseen scenarios. Unsupervised learning methods that don't necessarily encounter anomalies in training would be immensely…

Computer Vision and Pattern Recognition · Computer Science 2020-06-23 Louise Naud , Alexander Lavin

Unsupervised learning can leverage large-scale data sources without the need for annotations. In this context, deep learning-based autoencoders have shown great potential in detecting anomalies in medical images. However, especially…

Image and Video Processing · Electrical Eng. & Systems 2020-01-03 David Zimmerer , Simon Kohl , Jens Petersen , Fabian Isensee , Klaus Maier-Hein

Deep unsupervised anomaly detection in brain magnetic resonance imaging offers a promising route to identify pathological deviations without requiring lesion-specific annotations. Yet, fragmented evaluations, heterogeneous datasets, and…

Computer Vision and Pattern Recognition · Computer Science 2025-12-02 Alexander Frotscher , Christian F. Baumgartner , Thomas Wolfers

Anomaly detection using dimensionality reduction has been an essential technique for monitoring multidimensional data. Although deep learning-based methods have been well studied for their remarkable detection performance, their…

Machine Learning · Statistics 2018-12-24 Yasuhiro Ikeda , Kengo Tajiri , Yuusuke Nakano , Keishiro Watanabe , Keisuke Ishibashi

To achieve high-levels of autonomy, modern robots require the ability to detect and recover from anomalies and failures with minimal human supervision. Multi-modal sensor signals could provide more information for such anomaly detection…

Robotics · Computer Science 2020-12-17 Tianchen Ji , Sri Theja Vuppala , Girish Chowdhary , Katherine Driggs-Campbell

We present a refined version of the Anomaly Awareness framework for enhancing unsupervised anomaly detection. Our approach introduces minimal supervision into Variational Autoencoders (VAEs) through a two-stage training strategy: the model…

High Energy Physics - Phenomenology · Physics 2025-04-17 Adam Banda , Charanjit K. Khosa , Veronica Sanz

Through training on unlabeled data, anomaly detection has the potential to impact computer-aided diagnosis by outlining suspicious regions. Previous work on deep-learning-based anomaly detection has primarily focused on the reconstruction…

Image and Video Processing · Electrical Eng. & Systems 2019-12-03 David Zimmerer , Jens Petersen , Simon A. A. Kohl , Klaus H. Maier-Hein

Contrastive Analysis (CA) detects anomalies by contrasting patterns unique to a target group (e.g., unhealthy subjects) from those in a background group (e.g., healthy subjects). In the context of brain MRIs, existing CA approaches rely on…

Computer Vision and Pattern Recognition · Computer Science 2025-07-02 Cristiano Patrício , Carlo Alberto Barbano , Attilio Fiandrotti , Riccardo Renzulli , Marco Grangetto , Luis F. Teixeira , João C. Neves

Although unsupervised generative modeling of an image dataset using a Variational AutoEncoder (VAE) has been used to detect anomalous images, or anomalous regions in images, recent works have shown that this method often identifies images…

Computer Vision and Pattern Recognition · Computer Science 2020-08-13 David Dehaene , Pierre Eline

Semi-supervised and unsupervised Generative Adversarial Networks (GAN)-based methods have been gaining popularity in anomaly detection task recently. However, GAN training is somewhat challenging and unstable. Inspired from previous work in…

Computer Vision and Pattern Recognition · Computer Science 2019-02-20 Ha Son Vu , Daisuke Ueta , Kiyoshi Hashimoto , Kazuki Maeno , Sugiri Pranata , Sheng Mei Shen

Missing input sequences are common in medical imaging data, posing a challenge for deep learning models reliant on complete input data. In this work, inspired by MultiMAE [2], we develop a masked autoencoder (MAE) paradigm for multi-modal,…

Computer Vision and Pattern Recognition · Computer Science 2026-02-04 Ayhan Can Erdur , Christian Beischl , Daniel Scholz , Jiazhen Pan , Benedikt Wiestler , Daniel Rueckert , Jan C Peeken

Unsupervised Anomaly Detection has become a popular method to detect pathologies in medical images as it does not require supervision or labels for training. Most commonly, the anomaly detection model generates a "normal" version of an…

Image and Video Processing · Electrical Eng. & Systems 2023-09-26 Felix Meissen , Johannes Paetzold , Georgios Kaissis , Daniel Rueckert

While unsupervised variational autoencoders (VAE) have become a powerful tool in neuroimage analysis, their application to supervised learning is under-explored. We aim to close this gap by proposing a unified probabilistic model for…

Machine Learning · Computer Science 2019-07-15 Qingyu Zhao , Ehsan Adeli , Nicolas Honnorat , Tuo Leng , Kilian M. Pohl

Optimal computations under uncertainty require an adequate probabilistic representation about beliefs. Deep generative models, and specifically Variational Autoencoders (VAEs), have the potential to meet this demand by building latent…

Unsupervised anomaly detection methods offer a promising and flexible alternative to supervised approaches, holding the potential to revolutionize medical scan analysis and enhance diagnostic performance. In the current landscape, it is…

Image and Video Processing · Electrical Eng. & Systems 2023-08-29 Cosmin I. Bercea , Esther Puyol-Antón , Benedikt Wiestler , Daniel Rueckert , Julia A. Schnabel , Andrew P. King

This paper aims to conduct a comparative analysis of contemporary Variational Autoencoder (VAE) architectures employed in anomaly detection, elucidating their performance and behavioral characteristics within this specific task. The…

Computer Vision and Pattern Recognition · Computer Science 2024-08-27 Huy Hoang Nguyen , Cuong Nhat Nguyen , Xuan Tung Dao , Quoc Trung Duong , Dzung Pham Thi Kim , Minh-Tan Pham

Anomaly detection in MRI is of high clinical value in imaging and diagnosis. Unsupervised methods for anomaly detection provide interesting formulations based on reconstruction or latent embedding, offering a way to observe properties…

Image and Video Processing · Electrical Eng. & Systems 2022-11-29 Ayantika Das , Arun Palla , Keerthi Ram , Mohanasankar Sivaprakasam

Anomaly detection for Magnetic Resonance Images (MRIs) can be solved with unsupervised methods by learning the distribution of healthy images and identifying anomalies as outliers. In presence of an additional dataset of unlabelled data…

Machine Learning · Computer Science 2020-07-27 Alexandra-Ioana Albu , Alina Enescu , Luigi Malagò