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A cell membrane can be simply regarded as composite material consisting of lipid bilayer, membrane cytoskeleton beneath lipid bilayer, and proteins embedded in lipid bilayer and linked with membrane cytoskeleton if one only concerns its…

Other Quantitative Biology · Quantitative Biology 2007-06-26 Z. C. Tu , R. An , Z. C. Ou-Yang

We show existence and uniqueness of strong solutions to a Navier-Stokes/Cahn-Hilliard type system on a given two-dimensional evolving surface in the case of different densities and a singular (logarithmic) potential. The system describes a…

Analysis of PDEs · Mathematics 2024-08-15 Helmut Abels , Harald Garcke , Andrea Poiatti

Lipid bilayer membranes have a native (albeit small) permeability for water molecules. Under an external load, provided that the bilayer structure stays intact and does not suffer from poration or rupture, a lipid membrane deforms and its…

Soft Condensed Matter · Physics 2021-07-14 Bryan Quaife , Ashley Gannon , Y. -N. Young

A minimalist simulation model for lipid bilayers is presented. Each lipid is represented by a flexible chain of beads in implicit solvent. The hydrophobic effect is mimicked through an intermolecular pair potential localized at the…

Statistical Mechanics · Physics 2009-11-11 Grace Brannigan , Peter F. Philips , Frank L. H. Brown

The morphogenesis of cells and tissues involves an interplay between chemical signals and active forces on their surrounding surface layers. The complex interaction of hydrodynamics and material flows on such active surfaces leads to…

Cell Behavior · Quantitative Biology 2023-06-30 Sebastian Aland , Claudia Wohlgemuth

The two-phase Navier-Stokes Cahn-Hilliard (NSCH) mixture model is a key framework for simulating multiphase flows with non-matching densities. Developing fully discrete, energy-stable schemes for this model remains challenging, due to the…

Numerical Analysis · Mathematics 2026-02-05 Aaron Brunk , Marco F. P. ten Eikelder

The Cahn-Hilliard-Navier-Stokes (CHNS) partial differential equations (PDEs) provide a powerful framework for the study of the statistical mechanics and fluid dynamics of multiphase fluids. We provide an introduction to the equilibrium and…

Fluid Dynamics · Physics 2025-03-14 Nadia Bihari Padhan , Rahul Pandit

We reproduce the symmetric and asymmetric ``rippled'' $P_{\beta'}$ states of lipid membranes by Monte Carlo simulations of a coarse-grained molecular model for lipid-solvent mixtures. The structure and properties compare favorably with…

Biological Physics · Physics 2007-08-06 Olaf Lenz , Friederike Schmid

We introduce a new phase field model for binary mixtures of incompressible micropolar fluids, which are among the simplest categories of fluids exhibiting internal rotations. The model fulfils local and global dissipation inequalities so…

Analysis of PDEs · Mathematics 2025-05-01 Kin Shing Chan , Baoli Hao , Kei Fong Lam , Björn Stinner

We derive and analyze a new diffuse interface model for incompressible, viscous fluid mixtures with bulk-surface interaction. Our system consists of a Navier--Stokes--Cahn--Hilliard model in the bulk that is coupled to a surface…

Analysis of PDEs · Mathematics 2025-09-16 Patrik Knopf , Jonas Stange

Within the framework of the well-known curvature models, a fluid lipid bilayer membrane is regarded as a surface embedded in the three-dimensional Euclidean space whose equilibrium shapes are described in terms of its mean and Gaussian…

Mathematical Physics · Physics 2009-10-22 V. M. Vassilev , P. A. Djondjorov , I. M. Mladenov

In this paper we introduce a mesoscale continuum model for membranes made of two different types of amphiphilic lipids. The model extends work by Peletier and the second author [Arch. Ration. Mech. Anal. 193, 2009] for the one-phase case.…

Analysis of PDEs · Mathematics 2024-03-25 Jakob Fuchs , Matthias Röger

Detailed understanding of the coupling between fluid flow and solid deformation in porous media is crucial for the development biomedical devices and novel energy technologies relating to a wide range of geological and biological processes.…

Fluid Dynamics · Physics 2021-09-22 Francisco J. Carrillo

We employ a molecular model to study a ternary mixture of saturated lipid, with tails of sixteen carbons, a mono unsaturated lipid with tails of eighteen carbons, and cholesterol. The model, solved within mean-field theory, produces several…

Biological Physics · Physics 2009-11-11 R. Elliott , I. Szleifer , M. Schick

We present a technique to perform interface-resolved simulations of complex breakup dynamics in two-phase flows using the Cahn-Hilliard Navier-Stokes equations. The method dynamically decreases the interface thickness parameter in relevant…

We present a thermodynamically consistent phase-field model for simulating fluid transport across semi-permeable membranes, with a particular focus on osmotic pressure effects. The model extends the classical Navier-Stokes-Cahn-Hilliard…

Fluid Dynamics · Physics 2025-06-16 Ruihan Guo , Jie Shen , Shixin Xu , Xianmin Xu

Modelling interfacial dynamics with soluble surfactants in a multiphase system is a challenging task. Here, we consider the numerical approximation of a phase-field surfactant model with fluid flow. The nonlinearly coupled model consists of…

Computational Physics · Physics 2020-03-02 Guangpu Zhu , Jisheng Kou , Shuyu Sun , Jun Yao , Aifen Li

In this paper, we introduce a model describing the dynamic of vesicle membranes within an incompressible viscous fluid in $3D$ domains. The system consists of the Navier-Stokes equations, with an extra stress tensor depending on the…

Analysis of PDEs · Mathematics 2017-10-10 Blanca Climent-Ezquerra , Francisco Guillén-González

Simulating protein-membrane interactions is an important and dynamic area of research. A proper definition of electrostatic forces on membrane surfaces is necessary for developing electromechanical models of protein-membrane interactions.…

Analysis of PDEs · Mathematics 2013-09-24 Michael Mikucki , Y. C. Zhou

Relatively short peptides, such as toxins and antimicrobial-peptides, are known to insert themselves into cell membranes. On the basis of simple bead-spring models for the membrane lipids, the peptide, and water, detailed processes of the…

Soft Condensed Matter · Physics 2007-05-23 Mitsuharu Okazaki , Tomoki Watanabe , Naohito Urakami , Takashi Yamamoto