English

Electrostatic forces on charged surfaces of bilayer lipid membranes

Analysis of PDEs 2013-09-24 v2 Biomolecules

Abstract

Simulating protein-membrane interactions is an important and dynamic area of research. A proper definition of electrostatic forces on membrane surfaces is necessary for developing electromechanical models of protein-membrane interactions. Here we modeled the bilayer membrane as a continuum with general continuous distributions of lipids charges on membrane surfaces. A new electrostatic potential energy functional was then defined for this solvated protein-membrane system. We investigated the geometrical transformation properties of the membrane surfaces under a smooth velocity field. These properties allows us to apply the Hadamard-Zolesio structure theorem, and the electrostatic forces on membrane surfaces can be computed as the shape derivative of the electrostatic energy functional.

Keywords

Cite

@article{arxiv.1301.1104,
  title  = {Electrostatic forces on charged surfaces of bilayer lipid membranes},
  author = {Michael Mikucki and Y. C. Zhou},
  journal= {arXiv preprint arXiv:1301.1104},
  year   = {2013}
}