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There is growing interest in hypothesis generation with large language models (LLMs). However, fundamental questions remain: what makes a good hypothesis, and how can we systematically evaluate methods for hypothesis generation? To address…

Artificial Intelligence · Computer Science 2026-02-12 Haokun Liu , Sicong Huang , Jingyu Hu , Yangqiaoyu Zhou , Chenhao Tan

Hypothesis generation is a fundamental step in scientific discovery, yet it is increasingly challenged by information overload and disciplinary fragmentation. Recent advances in Large Language Models (LLMs) have sparked growing interest in…

The exponential growth of scientific knowledge has made the automated generation of scientific hypotheses that combine novelty, feasibility, and research value a core challenge. Existing methods based on large language models fail to…

Artificial Intelligence · Computer Science 2025-08-05 Shiyang Duan , Yuan Tian , Qi Bing , Xiaowei Shao

Large Language models have demonstrated promising performance in research ideation across scientific domains. Hypothesis development, the process of generating a highly specific declarative statement connecting a research idea with…

Artificial Intelligence · Computer Science 2025-08-25 Rosni Vasu , Chandrayee Basu , Bhavana Dalvi Mishra , Cristina Sarasua , Peter Clark , Abraham Bernstein

Hypothetical induction is recognized as the main reasoning type when scientists make observations about the world and try to propose hypotheses to explain those observations. Past research on hypothetical induction is under a constrained…

Computation and Language · Computer Science 2024-06-13 Zonglin Yang , Xinya Du , Junxian Li , Jie Zheng , Soujanya Poria , Erik Cambria

Large-scale language models are rapidly improving, performing well on a wide variety of tasks with little to no customization. In this work we investigate how language models can support science writing, a challenging writing task that is…

Human-Computer Interaction · Computer Science 2021-10-18 Katy Ilonka Gero , Vivian Liu , Lydia B. Chilton

Modern scientific discovery faces growing challenges in integrating vast and heterogeneous knowledge critical to breakthroughs in biomedicine and drug development. Traditional hypothesis-driven research, though effective, is constrained by…

Human-Computer Interaction · Computer Science 2025-07-24 Haoran Jiang , Shaohan Shi , Yunjie Yao , Chang Jiang , Quan Li

AI holds promise for transforming scientific processes, including hypothesis generation. Prior work on hypothesis generation can be broadly categorized into theory-driven and data-driven approaches. While both have proven effective in…

Artificial Intelligence · Computer Science 2025-01-10 Haokun Liu , Yangqiaoyu Zhou , Mingxuan Li , Chenfei Yuan , Chenhao Tan

Generating texts in scientific papers requires not only capturing the content contained within the given input but also frequently acquiring the external information called \textit{context}. We push forward the scientific text generation by…

Computation and Language · Computer Science 2021-10-22 Hong Chen , Hiroya Takamura , Hideki Nakayama

Large Language Models (LLMs) are transforming scientific hypothesis generation and validation by enabling information synthesis, latent relationship discovery, and reasoning augmentation. This survey provides a structured overview of…

Scientific hypothesis generation is a critical bottleneck in accelerating research, yet existing datasets for training and evaluating hypothesis-generating models are limited to single domains and lack explicit reasoning traces connecting…

Computation and Language · Computer Science 2026-04-01 Andrew Bouras , OMS-II Research Fellow

In this paper, we introduce SciGen, a new challenge dataset for the task of reasoning-aware data-to-text generation consisting of tables from scientific articles and their corresponding descriptions. Describing scientific tables goes beyond…

Computation and Language · Computer Science 2021-04-20 Nafise Sadat Moosavi , Andreas Rücklé , Dan Roth , Iryna Gurevych

While AI innovation accelerates rapidly, the intellectual process behind breakthroughs -- how researchers identify gaps, synthesize prior work, and generate insights -- remains poorly understood. The lack of structured data on scientific…

Artificial Intelligence · Computer Science 2026-01-09 Jiachen Liu , Maestro Harmon , Zechen Zhang

Current AI-powered research systems adopt a direct search-then-summarize paradigm that treats hypotheses as end products of scientific discovery. We argue this leaves a critical gap: hypotheses can serve a far more powerful role as…

Artificial Intelligence · Computer Science 2026-05-12 Michael Chin

Data intensive research requires the support of appropriate datasets. However, it is often time-consuming to discover usable datasets matching a specific research topic. We formulate the dataset discovery problem on an attributed…

Information Retrieval · Computer Science 2021-06-08 Basmah Altaf , Shichao Pei , Xiangliang Zhang

Knowledge production is often viewed as an endogenous process in which discovery arises through the recombination of existing theories, findings, and concepts. Yet given the vast space of potential recombinations, not all are equally…

Computers and Society · Computer Science 2025-09-29 Kara Kedrick , Wenlong Yang , Thomas Gebhart , Yang Wang , Russell J. Funk

We investigate whether large language models can perform the creative hypothesis generation that human researchers regularly do. While the error rate is high, generative AI seems to be able to effectively structure vast amounts of…

Computation and Language · Computer Science 2023-04-25 Yang Jeong Park , Daniel Kaplan , Zhichu Ren , Chia-Wei Hsu , Changhao Li , Haowei Xu , Sipei Li , Ju Li

Significant scientific discoveries have driven the progress of human civilisation. The explosion of scientific literature and data has created information barriers across disciplines that have slowed the pace of scientific discovery. Large…

Computation and Language · Computer Science 2023-11-13 Biqing Qi , Kaiyan Zhang , Haoxiang Li , Kai Tian , Sihang Zeng , Zhang-Ren Chen , Bowen Zhou

Hypothesis formulation and testing are central to empirical research. A strong hypothesis is a best guess based on existing evidence and informed by a comprehensive view of relevant literature. However, with exponential increase in the…

Computation and Language · Computer Science 2024-03-27 Sai Koneru , Jian Wu , Sarah Rajtmajer

Cross-domain scientific synthesis requires connecting mechanistic explanations across fragmented literature, a capability that remains challenging for both retrieval-based systems and unconstrained language models. While recent work has…

Computation and Language · Computer Science 2026-01-16 Sauhard Dubey
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