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Multimodal Large Language Models (MLLMs) have demonstrated impressive capabilities in understanding common visual elements, largely due to their large-scale datasets and advanced training strategies. However, their effectiveness in medical…

Medical image-language pre-training aims to align medical images with clinically relevant text to improve model performance on various downstream tasks. However, existing models often struggle with the variability and ambiguity inherent in…

Computer Vision and Pattern Recognition · Computer Science 2025-07-30 Shreyank N Gowda , Ruichi Zhang , Xiao Gu , Ying Weng , Lu Yang

Medical imaging datasets usually exhibit domain shift due to the variations of scanner vendors, imaging protocols, etc. This raises the concern about the generalization capacity of machine learning models. Domain generalization (DG), which…

Computer Vision and Pattern Recognition · Computer Science 2021-06-15 Chenxin Li , Qi Qi , Xinghao Ding , Yue Huang , Dong Liang , Yizhou Yu

With the increasing application of large language models (LLMs) in the medical domain, evaluating these models' performance using benchmark datasets has become crucial. This paper presents a comprehensive survey of various benchmark…

Medicine is inherently multimodal and multitask, with diverse data modalities spanning text, imaging. However, most models in medical field are unimodal single tasks and lack good generalizability and explainability. In this study, we…

Computer Vision and Pattern Recognition · Computer Science 2024-10-01 Lijian Xu , Hao Sun , Ziyu Ni , Hongsheng Li , Shaoting Zhang

Modern medical records include a vast amount of multimodal free text clinical data and imaging data from radiology, cardiology, and digital pathology. Fully mining such big data requires multitasking; otherwise, occult but important aspects…

Image and Video Processing · Electrical Eng. & Systems 2024-04-25 Chuang Niu , Qing Lyu , Christopher D. Carothers , Parisa Kaviani , Josh Tan , Pingkun Yan , Mannudeep K. Kalra , Christopher T. Whitlow , Ge Wang

This study presents Medical Vision Generalist (MVG), the first foundation model capable of handling various medical imaging tasks -- such as cross-modal synthesis, image segmentation, denoising, and inpainting -- within a unified…

Computer Vision and Pattern Recognition · Computer Science 2024-06-11 Sucheng Ren , Xiaoke Huang , Xianhang Li , Junfei Xiao , Jieru Mei , Zeyu Wang , Alan Yuille , Yuyin Zhou

Multimodal language models (MLMs) show promise for clinical decision support and diagnostic reasoning, raising the prospect of end-to-end automated medical image interpretation. However, clinicians are highly selective in adopting AI tools;…

Artificial Intelligence · Computer Science 2025-08-06 Mahtab Bigverdi , Wisdom Ikezogwo , Kevin Zhang , Hyewon Jeong , Mingyu Lu , Sungjae Cho , Linda Shapiro , Ranjay Krishna

Recent developments in prompt learning of large Vision-Language Models (VLMs) have significantly improved performance in target-specific tasks. However, these prompting methods often struggle to tackle the target-unspecific or generalizable…

Computer Vision and Pattern Recognition · Computer Science 2025-06-04 Fangming Cui , Yonggang Zhang , Xuan Wang , Xinmei Tian , Jun Yu

Data augmentations are widely used in training medical image deep learning models to increase the diversity and size of sparse datasets. However, commonly used augmentation techniques can result in loss of clinically relevant information…

Image and Video Processing · Electrical Eng. & Systems 2024-04-18 Adrit Rao , Andrea Fisher , Ken Chang , John Christopher Panagides , Katherine McNamara , Joon-Young Lee , Oliver Aalami

Foundation models are becoming valuable tools in medicine. Yet despite their promise, the best way to leverage Large Language Models (LLMs) in complex medical tasks remains an open question. We introduce a novel multi-agent framework, named…

Computation and Language · Computer Science 2024-10-31 Yubin Kim , Chanwoo Park , Hyewon Jeong , Yik Siu Chan , Xuhai Xu , Daniel McDuff , Hyeonhoon Lee , Marzyeh Ghassemi , Cynthia Breazeal , Hae Won Park

The advancement of large language models (LLMs) has opened new frontiers in natural language processing, particularly in specialized domains like healthcare. In this paper, we propose the Incremental Curriculum-Based Fine-Tuning (ICFT)…

Computation and Language · Computer Science 2025-02-04 Robert Long , Eric Gonzalez , Harrison Fuller

We propose a unified cross-domain transfer learning framework that leverages knowledge from multiple heterogeneous medical imaging datasets to improve performance across segmentation, classification, and object detection tasks. Our approach…

Computer Vision and Pattern Recognition · Computer Science 2026-05-05 Ceausescu Ciprian-Mihai , Anghelina Ion-Marian , Alexe Dumitru-Bogdan

Built on the power of LLMs, numerous multimodal large language models (MLLMs) have recently achieved remarkable performance on various vision-language tasks. However, most existing MLLMs and benchmarks primarily focus on single-image input…

Computer Vision and Pattern Recognition · Computer Science 2024-10-10 Haowei Liu , Xi Zhang , Haiyang Xu , Yaya Shi , Chaoya Jiang , Ming Yan , Ji Zhang , Fei Huang , Chunfeng Yuan , Bing Li , Weiming Hu

This thesis works to address a pivotal challenge in medical image analysis: the reliance on extensive labeled datasets, which are often limited due to the need for expert annotation and constrained by privacy and legal issues. By focusing…

Computer Vision and Pattern Recognition · Computer Science 2025-10-28 Cristian Simionescu

Existing Image Manipulation Localization (IML) methods mostly rely heavily on task-specific designs, making them perform well only on the target IML task, while joint training on multiple IML tasks causes significant performance…

Computer Vision and Pattern Recognition · Computer Science 2025-04-30 Chenfan Qu , Yiwu Zhong , Fengjun Guo , Lianwen Jin

Recent advancements in medical Large Language Models (LLMs) have showcased their powerful reasoning and diagnostic capabilities. Despite their success, current unified multimodal medical LLMs face limitations in knowledge update costs,…

Computation and Language · Computer Science 2025-06-25 Yucheng Zhou , Lingran Song , Jianbing Shen

Self-supervised learning has greatly facilitated medical image analysis by suppressing the training data requirement for real-world applications. Current paradigms predominantly rely on self-supervision within uni-modal image data, thereby…

Computer Vision and Pattern Recognition · Computer Science 2025-03-31 Shaohao Rui , Lingzhi Chen , Zhenyu Tang , Lilong Wang , Mianxin Liu , Shaoting Zhang , Xiaosong Wang

Deep learning for medical imaging is hampered by task-specific models that lack generalizability and prognostic capabilities, while existing 'universal' approaches suffer from simplistic conditioning and poor medical semantic understanding.…

Computer Vision and Pattern Recognition · Computer Science 2025-10-07 Numan Saeed , Tausifa Jan Saleem , Fadillah Maani , Muhammad Ridzuan , Hu Wang , Mohammad Yaqub

Image Quality Assessment (IQA) has progressed from scalar quality prediction to more interpretable, human-aligned evaluation paradigms. In this work, we address the emerging challenge of detailed and explainable IQA by proposing iDETEX-a…

Computer Vision and Pattern Recognition · Computer Science 2025-10-21 Zhaoran Zhao , Xinli Yue , Jianhui Sun , Yuhao Xie , Tao Shao , Liangchao Yao , Fan Xia , Yuetang Deng