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Printing custom DNA sequences is essential to scientific and biomedical research, but the technology can be used to manufacture plagues as well as cures. Just as ink printers recognize and reject attempts to counterfeit money, DNA…

We initiate the study of DNA-based distributed storage systems, where information is encoded across multiple DNA data storage containers to achieve robustness against container failures. In this setting, data are distributed over $M$…

Information Theory · Computer Science 2026-02-10 Adi Levy , Roni Con , Eitan Yaakobi , Han Mao Kiah

Sequencing a DNA strand, as part of the read process in DNA storage, produces multiple noisy copies which can be combined to produce better estimates of the original strand; this is called trace reconstruction. One can reduce the error rate…

Information Theory · Computer Science 2024-08-22 Sundara Rajan Srinivasavaradhan , Sivakanth Gopi , Henry D. Pfister , Sergey Yekhanin

As a possible implementation of data storage using DNA, multiple strands of DNA are stored in a liquid container so that, in the future, they can be read by an array of DNA readers in parallel. These readers will sample the strands with…

Information Theory · Computer Science 2024-09-04 Hsin-Po Wang , Venkatesan Guruswami

The yearly global production of data is growing exponentially, outpacing the capacity of existing storage media, such as tape and disk, and surpassing our ability to store it. DNA storage - the representation of arbitrary information as…

Quantitative Methods · Quantitative Biology 2023-10-04 Thomas Heinis , Roman Sokolovskii , Jamie J. Alnasir

In order to overcome the limitations imposed by DNA barcoding when multiplexing a large number of samples in the current generation of high-throughput sequencing instruments, we have recently proposed a new protocol that leverages advances…

Quantitative Methods · Quantitative Biology 2013-08-02 Denisa Duma , Mary Wootters , Anna C. Gilbert , Hung Q. Ngo , Atri Rudra , Matthew Alpert , Timothy J. Close , Gianfranco Ciardo , Stefano Lonardi

Due to the lack of parallel data in current Grammatical Error Correction (GEC) task, models based on Sequence to Sequence framework cannot be adequately trained to obtain higher performance. We propose two data synthesis methods which can…

Computation and Language · Computer Science 2021-12-28 Liner Yang , Chencheng Wang , Yun Chen , Yongping Du , Erhong Yang

Series of maximum distance quantum error-correcting codes are developed and analysed. For a given rate and given error-correction capability, quantum error-correcting codes with these specifications are constructed. The codes are explicit…

Information Theory · Computer Science 2020-04-14 Ted Hurley , Donny Hurley , Barry Hurley

The problem of storing large amounts of information safely for a long period of time has become essential. One of the most promising new data storage mediums are the polymer-based data storage systems, like the DNA-storage system. These…

Information Theory · Computer Science 2025-04-21 Ville Junnila , Tero Laihonen , Tuomo Lehtilä

In this work, we investigate a challenging problem, which has been considered to be an important criterion in designing codewords for DNA computing purposes, namely secondary structure avoidance in single-stranded DNA molecules. In short,…

Information Theory · Computer Science 2023-02-28 Tuan Thanh Nguyen , Kui Cai , Han Mao Kiah , Duc Tu Dao , Kees A. Schouhamer Immink

In this paper, we consider the outer channel for DNA-based data storage. When transmitting over the outer channel, each DNA string is treated as a unit/symbol that would be either correctly received, or erased, or corrupted by uniformly…

Information Theory · Computer Science 2025-09-23 Xuan He , Yi Ding , Kui Cai , Guanghui Song , Bin Dai , Xiaohu Tang

We present error-correcting codes that achieve the information-theoretically best possible trade-off between the rate and error-correction radius. Specifically, for every $0 < R < 1$ and $\eps> 0$, we present an explicit construction of…

Information Theory · Computer Science 2007-10-08 Venkatesan Guruswami , Atri Rudra

The theory of quantum error correction was established more than a decade ago as the primary tool for fighting decoherence in quantum information processing. Although great progress has already been made in this field, limited methods are…

Quantum Physics · Physics 2009-09-29 Zhuo Wang , Kai Sun , Hen Fan , Vlatko Vedral

Motivated by mutation processes occurring in in-vivo DNA-storage applications, a channel that mutates stored strings by duplicating substrings as well as substituting symbols is studied. Two models of such a channel are considered: one in…

Information Theory · Computer Science 2020-07-01 Yuanyuan Tang , Yonatan Yehezkeally , Moshe Schwartz , Farzad Farnoud

Product codes are a concatenated error-correction scheme that has been often considered for applications requiring very low bit-error rates, which demand that the error floor be decreased as much as possible. In this work, we consider…

Information Theory · Computer Science 2017-09-26 Carlo Condo , Francois Leduc-Primeau , Gabi Sarkis , Pascal Giard , Warren Gross

Discrete diffusion models are a powerful, emerging paradigm for code generation. They construct programs through iterative refinement of partially corrupted token sequences and enable parallel token refinement. Importantly, this paradigm…

Computation and Language · Computer Science 2026-05-19 Lize Shao , Michael Cardei , Zichen Xie , Ferdinando Fioretto , Wenxi Wang

Random linear network coding (RLNC) in theory achieves the max-flow capacity of multicast networks, at the cost of high decoding complexity. To improve the performance-complexity tradeoff, we consider the design of sparse network codes. A…

Information Theory · Computer Science 2016-04-20 Ye Li , Wai-Yip Chan , Steven D. Blostein

Encoding information in combinations of pre-synthesised deoxyribonucleic acid (DNA) strands (referred to as motifs) is an interesting approach to DNA storage that could potentially circumvent the prohibitive costs of…

Information Theory · Computer Science 2024-12-05 Roman Sokolovskii , Parv Agarwal , Luis Alberto Croquevielle , Zijian Zhou , Thomas Heinis

We study uniquely decodable codes and list decodable codes in the high-noise regime, specifically codes that are uniquely decodable from $\frac{1-\varepsilon}{2}$ fraction of errors and list decodable from $1-\varepsilon$ fraction of…

Information Theory · Computer Science 2024-11-06 Xin Li , Songtao Mao

Standard decoding approaches for convolutional codes, such as the Viterbi and BCJR algorithms, entail significant complexity when correcting synchronization errors. The situation worsens when multiple received sequences should be jointly…

Information Theory · Computer Science 2024-10-10 Anisha Banerjee , Lorenz Welter , Alexandre Graell i Amat , Antonia Wachter-Zeh , Eirik Rosnes