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Reconstruction codes are generalizations of error-correcting codes that can correct errors by a given number of noisy reads. The study of such codes was initiated by Levenshtein in 2001 and developed recently due to applications in modern…

Information Theory · Computer Science 2023-02-21 Zuo Ye , Xin Liu , Xiande Zhang , Gennian Ge

Relative compression, where a set of similar strings are compressed with respect to a reference string, is a very effective method of compressing DNA datasets containing multiple similar sequences. Relative compression is fast to perform…

Quantitative Methods · Quantitative Biology 2011-06-21 Shanika Kuruppu , Simon Puglisi , Justin Zobel

With the rapid increase of available digital data, DNA storage is identified as a storage media with high density and capability of long-term preservation, especially for archival storage systems. However, the encoding density (i.e., how…

Emerging Technologies · Computer Science 2021-08-26 Bingzhe Li , Li Ou , David Du

A method to construct and count all the linear codes (of arbitrary length) in $\mathbb{F}_{4}$ that are invariant under reverse permutation and that contain the repetition code is presented. These codes are suitable for constructing DNA…

Information Theory · Computer Science 2025-06-25 E. J. García-Claro

Efficient protein synthesis depends on the availability of charged tRNA molecules. With 61 different codons, shifting the balance among the tRNA abundances can lead to large changes in the protein synthesis rate. Previous theoretical work…

Subcellular Processes · Quantitative Biology 2020-01-01 Rebecca J. Rousseau , William Bialek

Clustering is a fundamental tool that has garnered significant interest across a wide range of applications including text analysis. To improve clustering accuracy, many researchers have incorporated background knowledge, typically in the…

Machine Learning · Computer Science 2026-01-19 Chaoqi Jia , Weihong Wu , Longkun Guo , Zhigang Lu , Chao Chen , Kok-Leong Ong

We study the problem of coded information retrieval for block-structured data, motivated by DNA-based storage systems where a database is partitioned into multiple files that must each be recoverable as an atomic unit. We initiate and…

Information Theory · Computer Science 2026-03-19 Daniella Bar-Lev

This paper performs the analysis necessary to bound the running time of known, efficient algorithms for generating all longest common subsequences. That is, we bound the running time as a function of input size for algorithms with time…

Discrete Mathematics · Computer Science 2007-05-23 Ronald I. Greenberg

Due to the redundant nature of DNA synthesis and sequencing technologies, a basic model for a DNA storage system is a multi-draw "shuffling-sampling" channel. In this model, a random number of noisy copies of each sequence is observed at…

Information Theory · Computer Science 2021-12-06 Kel Levick , Reinhard Heckel , Ilan Shomorony

Genomic data I used in many fields but, it has become known that most of the platforms used in the sequencing process produce significant errors. This means that the analysis and inferences generated from these data may have some errors…

Genomics · Quantitative Biology 2024-09-05 Ferdinand Kartriku , Robert Sowah , Charles Saah

Constrained codes are used to prevent errors from occurring in various data storage and data transmission systems. They can help in increasing the storage density of magnetic storage devices, in managing the lifetime of electronic storage…

Information Theory · Computer Science 2022-09-07 Ahmed Hareedy , Beyza Dabak , Robert Calderbank

In network communication, the source often transmits messages at several different information rates within a session. How to deal with information transmission and network error correction simultaneously under different rates is introduced…

Information Theory · Computer Science 2014-03-04 Xuan Guang , Fang-Wei Fu , Zhen Zhang

Motivated by polymer-based data-storage platforms that use chains of binary synthetic polymers as the recording media and read the content via tandem mass spectrometers, we propose a new family of codes that allows for unique string…

Information Theory · Computer Science 2019-04-22 Srilakshmi Pattabiraman , Ryan Gabrys , Olgica Milenkovic

Convolutional Neural Networks (CNN) have gained great success in many artificial intelligence tasks. However, finding a good set of hyperparameters for a CNN remains a challenging task. It usually takes an expert with deep knowledge, and…

Neural and Evolutionary Computing · Computer Science 2020-06-25 Xueli Xiao , Ming Yan , Sunitha Basodi , Chunyan Ji , Yi Pan

Among the biggest challenges in property-based testing (PBT) is the constrained random generation problem: given a predicate on program values, randomly sample from the set of all values satisfying that predicate, and only those values.…

Programming Languages · Computer Science 2026-04-15 Harrison Goldstein , Hila Peleg , Cassia Torczon , Daniel Sainati , Leonidas Lampropoulos , Benjamin C. Pierce

Motivated by polymer-based data-storage platforms that use chains of binary synthetic polymers as the recording media and read the content via tandem mass spectrometers, we propose a new family of codes that allows for both unique string…

Information Theory · Computer Science 2021-06-29 Srilakshmi Pattabiraman , Ryan Gabrys , Olgica Milenkovic

We present a Compression Tool, "GenBit Compress", for genetic sequences based on our new proposed "GenBit Compress Algorithm". Our Tool achieves the best compression ratios for Entire Genome (DNA sequences) . Significantly better…

Mathematical Software · Computer Science 2010-07-15 P. Raja Rajeswari , Allam Apparo , V. K. Kumar

We consider the problem of constructing linear Maximum Distance Separable (MDS) error-correcting codes with generator matrices that are sparsest and balanced. In this context, sparsest means that every row has the least possible number of…

Information Theory · Computer Science 2016-01-28 Wael Halbawi , Zihan Liu , Babak Hassibi

The general trace reconstruction problem seeks to recover an original sequence from its noisy copies independently corrupted by deletions, insertions, and substitutions. This problem arises in applications such as DNA data storage, a…

Machine Learning · Computer Science 2025-07-18 Franziska Weindel , Michael Girsch , Reinhard Heckel

Quantum error-correcting codes protect fragile quantum information by encoding it redundantly, but identifying codes that perform well in practice with minimal overhead remains difficult due to the combinatorial search space and the high…

Quantum Physics · Physics 2026-01-27 Yihua Chengyu , Richard Meister , Conor Carty , Sheng-Ku Lin , Roberto Bondesan
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