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Bidirectional causal relationships arising from mutual interactions between variables are commonly observed within biomedical, econometrical, and social science contexts. When such relationships are further complicated by unobserved…

Methodology · Statistics 2026-01-27 Yafang Deng , Kang Shuai , Shanshan Luo

Estimating causal quantities traditionally relies on bespoke estimators tailored to specific assumptions. Recently proposed Causal Foundation Models (CFMs) promise a more unified approach by amortising causal discovery and inference in a…

In designed experiments and surveys, known laws or design feat ures provide checks on the most relevant aspects of a model and identify the target parameters. In contrast, in most observational studies in the health and social sciences, the…

Methodology · Statistics 2010-01-18 Sander Greenland

Sensitivity to false assumptions (or false premises) in information-seeking questions is critical for robust question-answering (QA) systems. Recent work has shown that false assumptions in naturally occurring questions pose challenges to…

Computation and Language · Computer Science 2024-03-20 Ashwin Daswani , Rohan Sawant , Najoung Kim

Background: Policy evaluation studies that assess how state-level policies affect health-related outcomes are foundational to health and social policy research. The relative ability of newer analytic methods to address confounding, a key…

Causal effects are commonly defined as comparisons of the potential outcomes under treatment and control, but this definition is threatened by the possibility that the treatment or control condition is not well-defined, existing instead in…

Methodology · Statistics 2019-04-26 Raiden B. Hasegawa , Sameer K. Deshpande , Dylan S. Small , Paul R. Rosenbaum

Bell inequalities follow from a set of seemingly natural assumptions about how to provide a causal model of a Bell experiment. In the face of their violation, two types of causal models that modify some of these assumptions have been…

Quantum Physics · Physics 2022-05-11 Patrick J. Daley , Kevin J. Resch , Robert W. Spekkens

We present methods for causally interpretable meta-analyses that combine information from multiple randomized trials to estimate potential (counterfactual) outcome means and average treatment effects in a target population. We consider…

Nonlinear causal discovery from observational data imposes strict identifiability assumptions on the formulation of structural equations utilized in the data generating process. The evaluation of structure learning methods under assumption…

Machine Learning · Statistics 2024-12-17 Georg Velev , Stefan Lessmann

Quantitative evidence synthesis methods aim to combine data from multiple medical trials to infer relative effects of different interventions. A challenge arises when trials report continuous outcomes on different measurement scales. To…

Methodology · Statistics 2024-02-29 Annabel L Davies , A E Ades , Julian PT Higgins

Analysis of observational studies increasingly confronts the challenge of determining which of a possibly high-dimensional set of available covariates are required to satisfy the assumption of ignorable treatment assignment for estimation…

Methodology · Statistics 2022-03-23 Chanmin Kim , Mauricio Tec , Corwin M Zigler

Prevalent in biomedical applications (e.g., human phenotype research), multimodal datasets can provide valuable insights into the underlying physiological mechanisms. However, current machine learning (ML) models designed to analyze these…

Large Language Model Powered Multi-Agent Systems (MASs) are increasingly employed to automate complex real-world problems, such as programming and scientific discovery. Despite their promising, MASs are not without their flaws. However,…

Software Engineering · Computer Science 2025-09-18 Yu Ge , Linna Xie , Zhong Li , Yu Pei , Tian Zhang

One of the most fundamental problems in causal inference is the estimation of a causal effect when variables are confounded. This is difficult in an observational study, because one has no direct evidence that all confounders have been…

Machine Learning · Statistics 2014-11-03 Ricardo Silva , Robin Evans

The intuitive motivation for employing a sibling comparison design is to adjust for confounding that is constant within families. Such confounding can be caused by variables that otherwise might prove difficult to measure, for example…

This paper provides clear and practical guidance on the specification of imputation models when multiple imputation is used in conjunction with doubly robust estimation methods for causal inference. Through theoretical arguments and…

Methodology · Statistics 2025-12-19 Lucy D'Agostino McGowan

In system development, epistemic uncertainty is an ever-present possibility when reasoning about the causal factors during hazard analysis. Such uncertainty is common when complicated systems interact with one another, and it is dangerous…

Software Engineering · Computer Science 2017-10-20 Chris Leong , Tim Kelly , Rob Alexander

Approving and assessing new drugs is complex because multiple criteria must be considered simultaneously. A common approach is benefit-risk analysis, often conducted within a Bayesian framework to account for uncertainty and combine data…

The widespread use of machine learning and data-driven algorithms for decision making has been steadily increasing over many years. \emph{Bias} in the data can adversely affect this decision-making. We present a new mitigation strategy to…

Machine Learning · Computer Science 2025-07-25 Bruno Scarone , Alfredo Viola , Renée J. Miller , Ricardo Baeza-Yates

The study of associations and their causal explanations is a central research activity whose methodology varies tremendously across fields. Even within specialized subfields, comparisons across textbooks and journals reveals that the basics…

Methodology · Statistics 2025-10-13 Sander Greenland
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