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Outcome phenotype measurement error is rarely corrected in comparative effect estimation studies in observational pharmacoepidemiology. Quantitative bias analysis (QBA) is a misclassification correction method that algebraically adjusts…

When teaching and discussing statistical assumptions, our focus is oftentimes placed on how to test and address potential violations rather than the effects of violating assumptions on the estimates produced by our statistical models. The…

Methodology · Statistics 2022-06-14 Ian A Silver

The Causal Roadmap outlines a systematic approach to asking and answering questions of cause-and-effect: define the quantity of interest, evaluate needed assumptions, conduct statistical estimation, and carefully interpret results. To…

Methodology · Statistics 2024-05-30 Nerissa Nance , Maya L. Petersen , Mark van der Laan , Laura B. Balzer

Multimodal Sentiment Analysis (MSA) aims to understand human intentions by integrating emotion-related clues from diverse modalities, such as visual, language, and audio. Unfortunately, the current MSA task invariably suffers from unplanned…

Computation and Language · Computer Science 2024-07-08 Dingkang Yang , Mingcheng Li , Dongling Xiao , Yang Liu , Kun Yang , Zhaoyu Chen , Yuzheng Wang , Peng Zhai , Ke Li , Lihua Zhang

With medical tests becoming increasingly available, concerns about over-testing and over-treatment dramatically increase. Hence, it is important to understand the influence of testing on treatment selection in general practice. Most…

Methodology · Statistics 2020-08-11 Yun Li , Irina Bondarenko , Michael R. Elliott , Timothy P. Hofer , Jeremy M. G. Taylor

Medical diagnosis assistant (MDA) aims to build an interactive diagnostic agent to sequentially inquire about symptoms for discriminating diseases. However, since the dialogue records used to build a patient simulator are collected…

Computer Vision and Pattern Recognition · Computer Science 2023-07-04 Junfan Lin , Keze Wang , Ziliang Chen , Xiaodan Liang , Liang Lin

Observational studies are a key resource for causal inference but are often affected by systematic biases. Prior work has focused mainly on detecting these biases, via sensitivity analyses and comparisons with randomized controlled trials,…

Methodology · Statistics 2025-06-03 Ilker Demirel , Zeshan Hussain , Piersilvio De Bartolomeis , David Sontag

Causal inference from observational data requires assumptions. These assumptions range from measuring confounders to identifying instruments. Traditionally, causal inference assumptions have focused on estimation of effects for a single…

Machine Learning · Statistics 2019-03-04 Rajesh Ranganath , Adler Perotte

Causal mediation analysis is complicated with multiple effect definitions that require different sets of assumptions for identification. This paper provides a systematic explanation of such assumptions. We define five potential outcome…

Methodology · Statistics 2022-09-26 Trang Quynh Nguyen , Ian Schmid , Elizabeth L. Ogburn , Elizabeth A. Stuart

Causal inference often hinges on strong assumptions - such as no unmeasured confounding or perfect compliance - that are rarely satisfied in practice. Partial identification offers a principled alternative: instead of relying on…

Machine Learning · Computer Science 2025-08-20 Tobias Maringgele

Unmeasured confounding, selection bias, and measurement error are well-known sources of bias in epidemiologic research. Methods for assessing these biases have their own limitations. Many quantitative sensitivity analysis approaches…

Methodology · Statistics 2021-08-11 Louisa H. Smith , Maya B. Mathur , Tyler J. VanderWeele

Several problems in statistics involve the combination of high-variance unbiased estimators with low-variance estimators that are only unbiased under strong assumptions. A notable example is the estimation of causal effects while combining…

Methodology · Statistics 2023-05-25 Michael Oberst , Alexander D'Amour , Minmin Chen , Yuyan Wang , David Sontag , Steve Yadlowsky

Numerous multimodal misinformation benchmarks exhibit bias toward specific modalities, allowing detectors to make predictions based solely on one modality. While previous research has quantified bias at the dataset level or manually…

Artificial Intelligence · Computer Science 2025-11-11 Hehai Lin , Hui Liu , Shilei Cao , Jing Li , Haoliang Li , Wenya Wang

Estimation of causal effects involves crucial assumptions about the data-generating process, such as directionality of effect, presence of instrumental variables or mediators, and whether all relevant confounders are observed. Violation of…

Machine Learning · Computer Science 2021-09-01 Amit Sharma , Vasilis Syrgkanis , Cheng Zhang , Emre Kıcıman

In many applications of causal inference, the treatment received by one unit may influence the outcome of another, a phenomenon referred to as interference. Although there are several frameworks for conducting causal inference in the…

Methodology · Statistics 2025-11-27 Matvey Ortyashov , AmirEmad Ghassami

Real-world data, such as administrative claims and electronic health records, are increasingly used for safety monitoring and to help guide regulatory decision-making. In these settings, it is important to document analytic decisions…

Meta-analysis is a systematic approach for understanding a phenomenon by analyzing the results of many previously published experimental studies. It is central to deriving conclusions about the summary effect of treatments and interventions…

Computers and Society · Computer Science 2021-04-13 Lu Cheng , Dmitriy A. Katz-Rogozhnikov , Kush R. Varshney , Ioana Baldini

Models of various NLP tasks have been shown to exhibit stereotypes, and the bias in the question answering (QA) models is especially harmful as the output answers might be directly consumed by the end users. There have been datasets to…

Computation and Language · Computer Science 2024-06-18 Mingyu Derek Ma , Jiun-Yu Kao , Arpit Gupta , Yu-Hsiang Lin , Wenbo Zhao , Tagyoung Chung , Wei Wang , Kai-Wei Chang , Nanyun Peng

While observational data are routinely used to estimate causal effects of biomedical treatments, doing so requires special methods to adjust for observed confounding. These methods invariably rely on untestable statistical and causal…

Methodology · Statistics 2026-03-02 Arman Oganisian

How should researchers analyze randomized experiments in which the main outcome is latent and measured in multiple ways but each measure contains some degree of error? We first identify a critical study-specific noncomparability problem in…

Econometrics · Economics 2026-01-13 Jiawei Fu , Donald P. Green
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