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We show how to adjust the parameters of a thermodynamic computer by gradient descent in order to perform a desired computation at a specified observation time. Within a digital simulation of a thermodynamic computer, training proceeds by…

Statistical Mechanics · Physics 2025-09-22 Stephen Whitelam

Measurement and feedback allows an external agent to extract work from a system in contact with a single thermal bath. The maximum amount of work that can be extracted in a single measurement and the corresponding feedback loop is given by…

Statistical Mechanics · Physics 2024-01-19 L. Dinis , J. M. R. Parrondo

In striking contrast to equilibrium systems, inertia can profoundly alter the structure of active systems. Here, we demonstrate that driven systems can exhibit effective equilibrium-like states with increasing particle inertia, despite…

Soft Condensed Matter · Physics 2023-02-23 Ahmad K. Omar , Katherine Klymko , Trevor GrandPre , Phillip L. Geissler , John F. Brady

Collisional Brownian engines have recently gained attention as alternatives to conventional nanoscale engines. However, a comprehensive optimization of their performance, which could serve as a benchmark for future engine designs, is still…

Statistical Mechanics · Physics 2025-11-05 Gustavo A. L. Forão

The efficient manipulation of thermodynamic states within the finite time is fundamentally constrained by the intrinsic dissipative cost. While the slow-driving regime is well-characterized by a universal $1/\tau$-scaling of…

Statistical Mechanics · Physics 2026-02-17 Cong Fu , Youhui Lin , Shanhe Su , Yu-Han Ma

Since their invention in the 1980s [1], optical tweezers have found a wide range of applications, from biophotonics and mechanobiology to microscopy and optomechanics [2, 3, 4, 5]. Simulations of the motion of microscopic particles held by…

The influence of microscopic force fields on the motion of Brownian particles plays a fundamental role in a broad range of fields, including soft matter, biophysics, and active matter. Often, the experimental calibration of these force…

Computational Physics · Physics 2020-06-17 Aykut Argun , Tobias Thalheim , Stefano Bo , Frank Cichos , Giovanni Volpe

The thermodynamics of mesoscopic systems driven by time-varying temperatures is crucial for understanding biological systems, designing nanoscale engines, and performing micro-particle cooling. In this work, we analyze an underdamped…

Statistical Mechanics · Physics 2025-09-03 Felipe P. Abreu , Welles A. M. Morgado

Feedback can be utilized to convert information into useful work, making it an effective tool for increasing the performance of thermodynamic engines. Using feedback reversibility as a guiding principle, we devise a method for designing…

Statistical Mechanics · Physics 2015-06-03 Jordan M. Horowitz , Juan M. R. Parrondo

We propose an optimization strategy to control the dynamics of a stochastic system transferred from one thermal equilibrium to another and apply it experimentally to a Brownian particle in an optical trap under compression. Based on a…

The use of machine learning algorithms is an attractive way to produce very fast detector simulations for scattering reactions that can otherwise be computationally expensive. Here we develop a factorised approach where we deal with each…

Data Analysis, Statistics and Probability · Physics 2022-07-26 D. Darulis , R. Tyson , D. G. Ireland , D. I. Glazier , B. McKinnon , P. Pauli

Heat engines transform thermal energy into useful work, operating in a cyclic manner. For centuries, they have played a key role in industrial and technological development. Historically, only gases and liquids have been used as working…

Statistical Mechanics · Physics 2025-03-25 Irene Prieto-Rodríguez , Antonio Prados , Carlos A. Plata

This article proposes a self-consistent methodology for determining the mechanical adiabatic work of Brownian particles trapped in optical tweezers. Rather than varying the trap frequency, the proposed protocol involves displacing the trap…

Statistical Mechanics · Physics 2026-05-07 Pedro J. Colmenares

Considering the paradigmatic driven Brownian motion, we perform extensive numerical analysis on the performance of optimal linear-response processes far from equilibrium. We focus on the overdamped regime where exact optimal processes are…

Statistical Mechanics · Physics 2022-12-28 Lucas P. Kamizaki , Marcus V. S. Bonança , Sérgio R. muniz

We show that neural networks trained by evolutionary reinforcement learning can enact efficient molecular self-assembly protocols. Presented with molecular simulation trajectories, networks learn to change temperature and chemical potential…

Statistical Mechanics · Physics 2020-06-01 Stephen Whitelam , Isaac Tamblyn

In this paper we develop a dynamic form of Bayesian optimization for machine learning models with the goal of rapidly finding good hyperparameter settings. Our method uses the partial information gained during the training of a machine…

Machine Learning · Statistics 2014-06-17 Kevin Swersky , Jasper Snoek , Ryan Prescott Adams

Achieving precise control of colloidal self-assembly into specific patterns remains a longstanding challenge due to the complex process dynamics. Recently, machine learning-based state representation and reinforcement learning-based control…

Soft Condensed Matter · Physics 2025-12-19 Andres Lizano-Villalobos , Fangyuan Ma , Wentao Tang , Wei Sun , Xun Tang

For systems in an externally controllable time-dependent potential, the optimal protocol minimizes the mean work spent in a finite-time transition between two given equilibrium states. For overdamped dynamics which ignores inertia effects,…

Statistical Mechanics · Physics 2008-07-23 Alex Gomez-Marin , Tim Schmiedl , Udo Seifert

We present a feedback protocol that is able to confine a system to a single micro-state without heat dissipation. The protocol adjusts the Hamiltonian of the system in such a way that the Bayesian posterior distribution after measurement is…

Statistical Mechanics · Physics 2017-07-04 Léo Granger , Luis Dinis , Jordan M. Horowitz , Juan MR Parrondo

A supervised machine learning (ML) based computational methodology for the design of particulate multifunctional composite materials with desired thermal conductivity (TC) is presented. The design variables are physical descriptors of the…

Computational Physics · Physics 2025-07-25 Mohammad Saber Hashemi , Masoud Safdari , Azadeh Sheidaei