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Speed-of-sound (SoS) is a novel imaging biomarker for assessing biomechanical characteristics of soft tissues. SoS imaging in pulse-echo mode using conventional ultrasound systems with hand-held transducers has the potential to enable new…
Optical coherence elastography allows the characterization of the mechanical properties of tissues, and can be performed through estimating local displacement maps from subsequent acquisitions of a sample under different loads. This…
Many wormlike micellar systems exhibit appreciable shear thinning due to shear induced alignment. As the micelles get aligned introducing directionality in the system, the viscoelastic properties are no longer expected to be isotropic. An…
Recent ultrasound imaging modalities based on ultrasound computed tomography indicate a huge potential to detect pathologies is tissue due to altered biomechanical properties. Especially the imaging of speed-of-sound (SoS) distribution in…
Ultrasound shear wave elastography (SWE) is a noninvasive way to measure stiffness of soft tissue for medical diagnosis. In SWE imaging, an acoustic radiation force induces tissue displacement, which creates shear waves (SWs) that travel…
We introduce the variable coherence model (VCM) for simulating free-electron laser (FEL) pulses generated through self-amplified spontaneous emission. Building on the established partial coherence model of [T. Pfeifer et. al, Opt. Lett. 35,…
We report on the simultaneous and localized measurements of the diffusion coefficient and flow velocity based on the normalized autocorrelation function using optical coherence tomography (OCT). Our results on a flowing solution of…
Understanding stress-strain relationships in arteries is important for fundamental investigations in mechanobiology. Here we demonstrate the essential role of chemoelasticity in determining the mechanical properties of arterial tissues.…
Serial sectioning Optical Coherence Tomography (sOCT) is a high-throughput, label free microscopic imaging technique that is becoming increasingly popular to study post-mortem neurovasculature. Quantitative analysis of the vasculature…
Diffusion magnetic resonance imaging is an imaging technology designed to probe anatomical architectures of biological samples in an in vivo and non-invasive manner through measuring water diffusion. The contribution of this paper is…
Strain-stiffening is a well-documented behavior in soft biological materials such as liver and brain tissue. Measuring and characterizing this nonlinear response, which is commonly considered as a mechanism for damage prevention, is of…
Light propagating in tissue attains a spectrum that varies with location due to wavelength-dependent fluence attenuation by tissue optical properties, an effect that causes spectral corruption. Predictions of the spectral variations of…
In this methods paper, we explore the capabilities of high-speed ultrasound imaging (USI) to study fast varying and complex multi-phase structures in liquids and soft materials. Specifically, we assess the advantages and the limitations of…
Wave propagation on the surface of a material contains information about physical properties beneath its surface. We propose a method for inferring the thickness and stiffness of a structure from just a video of waves on its surface. Our…
Cortical thickness measurements from magnetic resonance imaging, an important biomarker in many neurodegenerative and neurological disorders, are derived by many tools from an initial voxel-wise tissue segmentation. White matter (WM)…
Shear-wave elastography (SWE) permits local estimation of tissue elasticity, an important imaging marker in biomedicine. This recently-developed, advanced technique assesses the speed of a laterally-travelling shear wave after an acoustic…
Ultrasound Strain Elastography (USE) is a powerful non-invasive imaging technique for assessing tissue mechanical properties, offering crucial diagnostic value across diverse clinical applications. However, its clinical application remains…
Non-contact measurement of the refractive index and thickness of multilayer biological tissues is of great significance for biomedical applications and can greatly improve medical diagnosis and treatment. In this work, we introduce a…
We study the impact of different loss functions on lesion segmentation from medical images. Although the Cross-Entropy (CE) loss is the most popular option when dealing with natural images, for biomedical image segmentation the soft Dice…
In this work we consider the inverse problem of reconstructing the optical properties of a layered medium from an elastography measurement where optical coherence tomography is used as the imaging method. We hereby model the sample as a…