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Rooted in genetics, human complex diseases are largely influenced by environmental factors. Existing literature has shown the power of integrative gene-environment interaction analysis by considering the joint effect of environmental…

Methodology · Statistics 2022-08-26 Jingyi Zhang , Xu Liu , Honglang Wang , Yuehua Cui

In epidemiological studies of air pollution and public health, estimating the health impact of exposure to air pollution may be hindered by the unknown functional form of the exposure-outcome association and by unmeasured confounding…

Methodology · Statistics 2026-01-28 Carlo Zaccardi , Pasquale Valentini , Luigi Ippoliti , Alexandra M. Schmidt

Often linear regression is used to perform mediation analysis. However, in many instances, the underlying relationships may not be linear, as in the case of placental-fetal hormones and fetal development. Although, the exact functional form…

Methodology · Statistics 2023-10-16 Qing Yin , Jong-Hyeon Jeong , Xu Qin , Shyamal D Peddada , Jennifer Adibi

Spatio-temporal prediction of levels of an environmental exposure is an important problem in environmental epidemiology. Our work is motivated by multiple studies on the spatio-temporal distribution of mobile source, or traffic related,…

Applications · Statistics 2014-11-14 Nikolay Bliznyuk , Christopher J. Paciorek , Joel Schwartz , Brent Coull

Several epidemiological studies have provided evidence that long-term exposure to fine particulate matter (PM2.5) increases mortality risk. Furthermore, some population characteristics (e.g., age, race, and socioeconomic status) might play…

Methodology · Statistics 2023-11-01 Dafne Zorzetto , Falco J. Bargagli-Stoffi , Antonio Canale , Francesca Dominici

Studies have shown that exposure to air pollution, even at low levels, significantly increases mortality. As regulatory actions are becoming prohibitively expensive, robust evidence to guide the development of targeted interventions to…

Applications · Statistics 2018-02-20 Kwonsang Lee , Dylan S. Small , Francesca Dominici

In this paper, a useful reinterpretation of the city as a porous medium justifies the application of well-known models on fluid dynamics to develop a multi-model study of urban air pollution due to traffic flow in a large city. Thus, to…

Numerical Analysis · Mathematics 2025-02-21 N. Garcia-Chan , L. J. Alvarez-Vazquez , A. Martinez , M. E. Vazquez-Mendez

In this work we present a statistical approach to distinguish and interpret the complex relationship between several predictors and a response variable at the small area level, in the presence of i) high correlation between the predictors…

Applications · Statistics 2016-02-24 Silvia Liverani , Aurore Lavigne , Marta Blangiardo

In this article, we analyze perinatal data with birth weight (BW) as primarily interesting response variable. Gestational age (GA) is usually an important covariate and included in polynomial form. However, in opposition to this univariate…

Methodology · Statistics 2021-11-02 Jonathan Rathjens , Arthur Kolbe , Jürgen Hölzer , Katja Ickstadt , Nadja Klein

Statistical techniques used in air pollution modelling usually lack the possibility to understand which predictors affect air pollution in which functional form; and are not able to regress on exceedances over certain thresholds imposed by…

Methodology · Statistics 2021-05-25 Nadja Klein , Jorge Mateu

The substantial threat of concurrent air pollutants to public health is increasingly severe under climate change. To identify the common drivers and extent of spatio-temporal similarity of PM2.5 and ozone, this paper proposed a log…

Atmospheric and Oceanic Physics · Physics 2024-04-24 Jianan Pan , Kunyang He , Kai Wang , Qing Mu , Chengxiu Ling

According to the Lancet report on the global burden of disease published in October 2020, air pollution is among the five highest risk factors for global health, reducing life expectancy on average by 20 months. This paper describes a…

Applications · Statistics 2023-01-18 D K Arvind , S Maiya

Health outcomes depend on complex environmental and sociodemographic factors whose effects change over location and time. Only recently has fine-grained spatial and temporal data become available to study these effects, namely the MEDSAT…

Machine Learning · Computer Science 2025-01-07 Ishaan Maitra , Raymond Lin , Eric Chen , Jon Donnelly , Sanja Šćepanović , Cynthia Rudin

Very unhealthy air quality is consistently connected with numerous diseases. Appropriate extreme analysis and accurate predictions are in rising demand for exploring potential linked causes and for providing suggestions for the…

Applications · Statistics 2023-08-25 Kai Wang , Chengxiu Ling , Ying Chen , Zhengjun Zhang

The analysis of environmental mixtures is of growing importance in environmental epidemiology, and one of the key goals in such analyses is to identify exposures and their interactions that are associated with adverse health outcomes.…

Methodology · Statistics 2021-03-22 Srijata Samanta , Joseph Antonelli

Global ambient air pollution, a transboundary challenge, is typically addressed through interventions relying on data from spatially sparse and heterogeneously placed monitoring stations. These stations often encounter temporal data gaps…

Machine Learning · Computer Science 2024-02-19 Liam J Berrisford , Hugo Barbosa , Ronaldo Menezes

Joint models for a wide class of response variables and longitudinal measurements consist on a mixed-effects model to fit longitudinal trajectories whose random effects enter as covariates in a generalized linear model for the primary…

Methodology · Statistics 2014-07-03 Rolando De la Cruz , Cristian Meza , Ana Arribas-Gil , Raymond J. Carroll

Emission control technologies installed on power plants are a key feature of many air pollution regulations in the US. While such regulations are predicated on the presumed relationships between emissions, ambient air pollution, and human…

Methodology · Statistics 2019-02-19 Chanmin Kim , Michael Daniels , Joseph Hogan , Christine Choirat , Corwin Zigler

Airborne particulate matter (PM2.5) is a major public health concern in urban environments, where population density and emission sources exacerbate exposure risks. We present a novel Bayesian spatiotemporal fusion model to estimate monthly…

Motivated by analyzing a national data base of annual air pollution and cardiovascular disease mortality rate for 3100 counties in the U.S. (areal data), we develop a novel statistical framework to automatically detect spatially varying…

Applications · Statistics 2015-11-19 Shuo Chen , Chengsheng Jiang , Lance Waller