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We present an approach to estimate distance-dependent heterogeneous associations between point-referenced exposures to built environment characteristics and health outcomes. By estimating associations that depend non-linearly on distance…

Methodology · Statistics 2021-07-14 Adam Peterson , Emma Sanchez-Vaznaugh , Brisa Sanchez

Distributed lag non-linear models (DLNMs) are a popular approach to flexibly model the effect of time-delayed exposures. Classical DLNMs specify a common exposure-lag-response relationship across geographical areas. However, this…

Methodology · Statistics 2026-03-20 Sara Rutten , Thomas Neyens , Elisa Duarte , Antonio Gasparrini , Christel Faes

In environmental health research there is often interest in the effect of an exposure on a health outcome assessed on the same day and several subsequent days or lags. Distributed lag nonlinear models (DLNM) are a well-established…

Methodology · Statistics 2023-10-05 Daniel Mork , Ander Wilson

Fine particulate matter (PM2.5) measured at a given location is a mix of pollution generated locally and pollution traveling long distances in the atmosphere. Therefore, the identification of spatial scales associated with health effects…

Methodology · Statistics 2016-09-19 Joseph Antonelli , Joel Schwartz , Itai Kloog , Brent Coull

Measuring the impact of an environmental point source exposure on the risk of disease, like cancer or childhood asthma, is well-developed. Modeling how an environmental health hazard that is extensive in space, like a wastewater canal,…

Methodology · Statistics 2024-07-29 Rob Trangucci , Jesse Contreras , Jon Zelner , Joseph N. S. Eisenberg , Yang Chen

Air pollution remains a major environmental risk factor that is often associated with adverse health outcomes. However, quantifying and evaluating its effects on human health is challenging due to the complex nature of exposure data. Recent…

Methodology · Statistics 2025-06-02 Soumyakanti Pan , Sudipto Banerjee

Distributed lag models (DLMs) express the cumulative and delayed dependence between pairs of time-indexed response and explanatory variables. In practical application, users of DLMs examine the estimated influence of a series of lagged…

Applications · Statistics 2018-01-23 Alastair Rushworth

Pollutant exposure during gestation is a known and adverse factor for birth and health outcomes. However, the links between prenatal air pollution exposures and educational outcomes are less clear, in particular the critical windows of…

Methodology · Statistics 2022-10-11 Yunan Gao , Daniel R. Kowal

In air pollution studies, dispersion models provide estimates of concentration at grid level covering the entire spatial domain, and are then calibrated against measurements from monitoring stations. However, these different data sources…

Applications · Statistics 2020-08-17 Chiara Forlani , Samir Bhatt , Michela Cameletti , Elias Krainski , Marta Blangiardo

The analysis of data arising from environmental health studies which collect a large number of measures of exposure can benefit from using latent variable models to summarize exposure information. However, difficulties with estimation of…

Applications · Statistics 2009-08-21 Brisa N. Sánchez , Esben Budtz-Jørgensen , Louise M. Ryan

Humans are routinely exposed to mixtures of chemical and other environmental factors, making the quantification of health effects associated with environmental mixtures a critical goal for establishing environmental policy sufficiently…

We investigate the relative merit of phase-based methods---mean phase coherence, unweighted and weighted phase lag index---for estimating the strength of interactions between dynamical systems from empirical time series which are affected…

Neurons and Cognition · Quantitative Biology 2014-09-16 Stephan Porz , Matthäus Kiel , Klaus Lehnertz

When examining the relationship between an exposure and an outcome, there is often a time lag between exposure and the observed effect on the outcome. A common statistical approach for estimating the relationship between the outcome and…

Methodology · Statistics 2025-04-28 Seongwon Im , Ander Wilson , Daniel Mork

Estimation of the long-term health effects of air pollution is a challenging task, especially when modelling small-area disease incidence data in an ecological study design. The challenge comes from the unobserved underlying spatial…

Methodology · Statistics 2013-05-24 Duncan Lee , Alastair Rushworth , Sujit K. Sahu

There is wide interest in studying how the distribution of a continuous response changes with a predictor. We are motivated by environmental applications in which the predictor is the dose of an exposure and the response is a health…

Methodology · Statistics 2018-05-10 Antonio Canale , Daniele Durante , David Dunson

We develop Bayesian nonparametric models for spatially indexed data of mixed type. Our work is motivated by challenges that occur in environmental epidemiology, where the usual presence of several confounding variables that exhibit complex…

Methodology · Statistics 2014-10-17 Georgios Papageorgiou , Sylvia Richardson , Nicky Best

A typical problem in air pollution epidemiology is exposure assessment for individuals for which health data are available. Due to the sparsity of monitoring sites and the limited temporal frequency with which measurements of air pollutants…

A key goal of environmental health research is to assess the risk posed by mixtures of pollutants. As epidemiologic studies of mixtures can be expensive to conduct, it behooves researchers to incorporate prior knowledge about mixtures into…

Methodology · Statistics 2022-04-04 Glen McGee , Ander Wilson , Brent A Coull , Thomas F Webster

Air pollution is a major risk factor for global health, with both ambient and household air pollution contributing substantial components of the overall global disease burden. One of the key drivers of adverse health effects is fine…

This paper presents an approach to estimating the health effects of an environmental hazard. The approach is general in nature, but is applied here to the case of air pollution. It uses a computer model involving ambient pollution and…

Applications · Statistics 2007-11-01 Gavin Shaddick , Duncan Lee , James V. Zidek , Ruth Salway