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Background: The potential of large language models (LLMs) to automate and support pharmacoepidemiologic study design is an emerging area of interest, yet their reliability remains insufficiently characterized. General-purpose LLMs often…

Computation and Language · Computer Science 2026-04-21 Xinyao Zhang , Nicole Sonne Heckmann , Manuela Del Castillo Suero , Francesco Paolo Speca , Maurizio Sessa

The rapid advancement of large language models (LLMs) has accelerated their integration into clinical decision support, particularly in prescription review. To enable systematic and fine-grained evaluation, we developed RxBench, a…

Computation and Language · Computer Science 2025-12-03 Yan Yang , Mouxiao Bian , Peiling Li , Bingjian Wen , Ruiyao Chen , Kangkun Mao , Xiaojun Ye , Tianbin Li , Pengcheng Chen , Bing Han , Jie Xu , Kaifeng Qiu , Junyan Wu

Large Language Models~(LLMs) have demonstrated capabilities across various applications but face challenges such as hallucination, limited reasoning abilities, and factual inconsistencies, especially when tackling complex, domain-specific…

Recent advances in the intrinsic reasoning capabilities of large language models (LLMs) have given rise to LLM-based agent systems that exhibit near-human performance on a variety of automated tasks. However, although these systems share…

Artificial Intelligence · Computer Science 2025-08-26 Bingxi Zhao , Lin Geng Foo , Ping Hu , Christian Theobalt , Hossein Rahmani , Jun Liu

Large Language Models (LLMs) offer new opportunities to accelerate complex interdisciplinary research domains. Epidemic modeling, characterized by its complexity and reliance on network science, dynamical systems, epidemiology, and…

Social and Information Networks · Computer Science 2026-02-26 Mohammad Hossein Samaei , Faryad Darabi Sahneh , Lee W. Cohnstaedt , Caterina Scoglio

As large language models have shown remarkable capabilities in conversing via natural language, the question arises as to how LLMs could potentially assist chemical engineers in research and industry with domain-specific tasks. We generate…

Programming Languages · Computer Science 2025-03-24 Sophia Rupprecht , Yassine Hounat , Monisha Kumar , Giacomo Lastrucci , Artur M. Schweidtmann

Conversational agents have made significant progress since ELIZA, expanding their role across various domains, including healthcare, education, and customer service. As these agents become increasingly integrated into daily human…

Human-Computer Interaction · Computer Science 2025-07-04 Paulo Ricardo Knob , Leonardo Scholler , Juliano Rigatti , Soraia Raupp Musse

There is an increasing interest in developing LLMs for medical diagnosis to improve diagnosis efficiency. Despite their alluring technological potential, there is no unified and comprehensive evaluation criterion, leading to the inability…

Computation and Language · Computer Science 2023-08-16 Xiaoming Shi , Jie Xu , Jinru Ding , Jiali Pang , Sichen Liu , Shuqing Luo , Xingwei Peng , Lu Lu , Haihong Yang , Mingtao Hu , Tong Ruan , Shaoting Zhang

We introduce Youtu-LLM, a lightweight yet powerful language model that harmonizes high computational efficiency with native agentic intelligence. Unlike typical small models that rely on distillation, Youtu-LLM (1.96B) is pre-trained from…

Automated sentiment analysis using Large Language Model (LLM)-based models like ChatGPT, Gemini or LLaMA2 is becoming widespread, both in academic research and in industrial applications. However, assessment and validation of their…

Computation and Language · Computer Science 2024-02-06 Alessio Buscemi , Daniele Proverbio

Large Language Model (LLM) based agents are powerful yet fundamentally static after deployment, lacking the ability to autonomously expand capabilities, generate new tools, or evolve their reasoning. This work introduces a hierarchical…

Computation and Language · Computer Science 2026-01-21 Indrajit Kar , Sammy Zonunpuia , Zonunfeli Ralte

While large language models (LLMs) have shown promise in diagnostic dialogue, their capabilities for effective management reasoning - including disease progression, therapeutic response, and safe medication prescription - remain…

Chemical synthesis, as a foundational methodology in the creation of transformative molecules, exerts substantial influence across diverse sectors from life sciences to materials and energy. Current chemical synthesis practices emphasize…

While Large Language Models (LLMs) are being quickly adapted to many domains, including healthcare, their strengths and pitfalls remain under-explored. In our study, we examine the effects of prompt engineering to guide Large Language…

Computation and Language · Computer Science 2024-09-04 Daniil Filienko , Yinzhou Wang , Caroline El Jazmi , Serena Xie , Trevor Cohen , Martine De Cock , Weichao Yuwen

The integration of a complex set of Electronic Design Automation (EDA) tools to enhance interoperability is a critical concern for circuit designers. Recent advancements in large language models (LLMs) have showcased their exceptional…

Hardware Architecture · Computer Science 2024-09-24 Zhuolun He , Haoyuan Wu , Xinyun Zhang , Xufeng Yao , Su Zheng , Haisheng Zheng , Bei Yu

As Large Language Models (LLMs) have become integral to both research and daily operations, rigorous evaluation is crucial. This assessment is important not only for individual tasks but also for understanding their societal impact and…

Software Engineering · Computer Science 2024-04-02 Zeeshan Rasheed , Muhammad Waseem , Kari Systä , Pekka Abrahamsson

Recent advancements in machine learning have significantly improved the identification of disease-associated genes from gene expression datasets. However, these processes often require extensive expertise and manual effort, limiting their…

Machine Learning · Computer Science 2025-04-09 Haoyang Liu , Shuyu Chen , Ye Zhang , Haohan Wang

This study investigates the efficacy of Large Language Models (LLMs) in interactive language therapy for high-functioning autistic adolescents. With the rapid advancement of artificial intelligence, particularly in natural language…

Human-Computer Interaction · Computer Science 2023-11-17 Yujin Cho , Mingeon Kim , Seojin Kim , Oyun Kwon , Ryan Donghan Kwon , Yoonha Lee , Dohyun Lim

Large language models (LLMs) have revolutionized natural language processing (NLP) with impressive performance across various text-based tasks. However, the extension of text-dominant LLMs to with speech generation tasks remains…

Computation and Language · Computer Science 2024-10-29 Maohao Shen , Shun Zhang , Jilong Wu , Zhiping Xiu , Ehab AlBadawy , Yiting Lu , Mike Seltzer , Qing He

Recently, large language models (LLMs) have demonstrated remarkable problem-solving capabilities by autonomously integrating with external tools for collaborative reasoning. However, due to the inherently complex and diverse nature of…

Artificial Intelligence · Computer Science 2025-11-03 Mengjie Deng , Guanting Dong , Zhicheng Dou