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Recent trends in cell segmentation have shifted towards universal models to handle diverse cell morphologies and imaging modalities. However, for continuously emerging cell types and imaging techniques, these models still require hundreds…

Computer Vision and Pattern Recognition · Computer Science 2024-12-03 Peilin Zhou , Bo Du , Yongchao Xu

Single-cell RNA sequencing (scRNA-seq) has revolutionized our ability to analyze gene expression at the resolution of individual cells, providing unprecedented insights into cellular heterogeneity and complex biological systems. This paper…

Other Quantitative Biology · Quantitative Biology 2024-06-11 Megha Patel , Nimish Magre , Himanshi Motwani , Nik Bear Brown

Relational learning is a challenging problem that has motivated a wide range of approaches, including graph-based models (e.g., graph neural networks, graph transformers), tabular methods (e.g., tabular foundation models), and…

Machine Learning · Computer Science 2026-05-11 Xingyue Huang , Louis Tichelman , Jinwoo Kim , Krzysztof Olejniczak , İsmail İlkan Ceylan

Large language models (LLMs) are increasingly used for complex tasks that require multiple generation calls, advanced prompting techniques, control flow, and structured inputs/outputs. However, efficient systems are lacking for programming…

Advancements in large language models (LLMs) allow them to address diverse questions using human-like interfaces. Still, limitations in their training prevent them from answering accurately in scenarios that could benefit from multiple…

Artificial Intelligence · Computer Science 2025-04-09 Yoshitaka Inoue , Tianci Song , Xinling Wang , Augustin Luna , Tianfan Fu

Cell type identification from single-cell transcriptomic data is a common goal of single-cell RNA sequencing (scRNAseq) data analysis. Neural networks have been employed to identify cell types from scRNAseq data with high performance.…

Genomics · Quantitative Biology 2020-05-11 Xishuang Dong , Shanta Chowdhury , Uboho Victor , Xiangfang Li , Lijun Qian

The exploration of cellular heterogeneity within the tumor microenvironment (TME) via single-cell RNA sequencing (scRNA-seq) is essential for understanding cancer progression and response to therapy. Current scRNA-seq approaches, however,…

Genomics · Quantitative Biology 2025-02-06 Yu-An Huang , Yue-Chao Li , Hai-Ru You , Jie Pan , Xiyue Cao , Xinyuan Li , Zhi-An Huang , Zhu-Hong You

Large Language Model (LLM)-based agents exhibit significant potential across various domains, operating as interactive systems that process environmental observations to generate executable actions for target tasks. The effectiveness of…

Computation and Language · Computer Science 2024-08-20 Mengkang Hu , Tianxing Chen , Qiguang Chen , Yao Mu , Wenqi Shao , Ping Luo

Medical Decision-Making (MDM) is a multi-faceted process that requires clinicians to assess complex multi-modal patient data patient, often collaboratively. Large Language Models (LLMs) promise to streamline this process by synthesizing…

In recent years, several unsupervised cell segmentation methods have been presented, trying to omit the requirement of laborious pixel-level annotations for the training of a cell segmentation model. Most if not all of these methods handle…

Computer Vision and Pattern Recognition · Computer Science 2023-12-04 Mehdi Naouar , Gabriel Kalweit , Anusha Klett , Yannick Vogt , Paula Silvestrini , Diana Laura Infante Ramirez , Roland Mertelsmann , Joschka Boedecker , Maria Kalweit

Data annotation remains a significant bottleneck in the Humanities and Social Sciences, particularly for complex semantic tasks such as metaphor identification. While Large Language Models (LLMs) show promise, a significant gap remains…

Computation and Language · Computer Science 2026-02-06 Bingru Li

Large language models (LLMs) are transforming cellular biology by enabling the development of "virtual cells"--computational systems that represent, predict, and reason about cellular states and behaviors. This work provides a comprehensive…

Computation and Language · Computer Science 2025-10-10 Krinos Li , Xianglu Xiao , Shenglong Deng , Lucas He , Zijun Zhong , Yuanjie Zou , Zhonghao Zhan , Zheng Hui , Weiye Bao , Guang Yang

Fault diagnosis of lithium-ion batteries is critical for system safety. While existing deep learning methods exhibit superior detection accuracy, their "black-box" nature hinders interpretability. Furthermore, restricted by binary…

Artificial Intelligence · Computer Science 2026-01-01 Songqi Zhou , Ruixue Liu , Boman Su , Jiazhou Wang , Yixing Wang , Benben Jiang

Large language models (LLMs) excel at natural language tasks but are limited by their static parametric knowledge, especially in knowledge-intensive task. Retrieval-augmented generation (RAG) mitigates this by integrating external…

Artificial Intelligence · Computer Science 2025-10-10 Yi Jiang , Lei Shen , Lujie Niu , Sendong Zhao , Wenbo Su , Bo Zheng

Code translation transforms code between programming languages while preserving functionality, which is critical in software development and maintenance. While traditional learning-based code translation methods have limited effectiveness…

Software Engineering · Computer Science 2026-04-08 Zhiqiang Yuan , Weitong Chen , Hanlin Wang , Xin Peng , Zhenpeng Chen , Yiling Lou

Cell detection is an essential task in cell image analysis. Recent deep learning-based detection methods have achieved very promising results. In general, these methods require exhaustively annotating the cells in an entire image. If some…

Computer Vision and Pattern Recognition · Computer Science 2021-07-22 Kazuma Fujii , Daiki Suehiro , Kazuya Nishimura , Ryoma Bise

We present a multi-agent system for automation of scientific research tasks, cmbagent (https://github.com/CMBAgents/cmbagent). The system is formed by about 30 Large Language Model (LLM) agents and implements a Planning & Control strategy…

Understanding cell identity and function through single-cell level sequencing data remains a key challenge in computational biology. We present a novel framework that leverages gene-specific textual annotations from the NCBI Gene database…

Genomics · Quantitative Biology 2025-05-14 Douglas Jiang , Zilin Dai , Luxuan Zhang , Qiyi Yu , Haoqi Sun , Feng Tian

Knowledge tagging for questions is vital in modern intelligent educational applications, including learning progress diagnosis, practice question recommendations, and course content organization. Traditionally, these annotations have been…

Computation and Language · Computer Science 2024-12-20 Hang Li , Tianlong Xu , Ethan Chang , Qingsong Wen

Alzheimer's disease (AD) is a progressive and irreversible neurodegenerative disease. Early and precise diagnosis of AD is crucial for timely intervention and treatment planning to alleviate the progressive neurodegeneration. However, most…

Image and Video Processing · Electrical Eng. & Systems 2025-07-29 Wenlong Hou , Guangqian Yang , Ye Du , Yeung Lau , Lihao Liu , Junjun He , Ling Long , Shujun Wang