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Large Language Models (LLMs) are revolutionizing bioinformatics, enabling advanced analysis of DNA, RNA, proteins, and single-cell data. This survey provides a systematic review of recent advancements, focusing on genomic sequence modeling,…

Computation and Language · Computer Science 2026-03-03 Zhenyu Wang , Zikang Wang , Jiyue Jiang , Pengan Chen , Xiangyu Shi , Yu Li

Detecting semantic types of columns in data lake tables is an important application. A key bottleneck in semantic type detection is the availability of human annotation due to the inherent complexity of data lakes. In this paper, we propose…

Databases · Computer Science 2024-08-30 Chenjie Li , Dan Zhang , Jin Wang

Span annotation - annotating specific text features at the span level - can be used to evaluate texts where single-score metrics fail to provide actionable feedback. Until recently, span annotation was done by human annotators or fine-tuned…

Recent advancements in Large Language Models (LLMs) have led to the development of intelligent LLM-based agents capable of interacting with graphical user interfaces (GUIs). These agents demonstrate strong reasoning and adaptability,…

Artificial Intelligence · Computer Science 2025-04-16 Wenjia Jiang , Yangyang Zhuang , Chenxi Song , Xu Yang , Joey Tianyi Zhou , Chi Zhang

The believable simulation of multi-user behavior is crucial for understanding complex social systems. Recently, large language models (LLMs)-based AI agents have made significant progress, enabling them to achieve human-like intelligence…

Artificial Intelligence · Computer Science 2024-12-16 Yijun Liu , Wu Liu , Xiaoyan Gu , Yong Rui , Xiaodong He , Yongdong Zhang

The era of intelligent agents is upon us, driven by revolutionary advancements in large language models. Large Language Model (LLM) agents, with goal-driven behaviors and dynamic adaptation capabilities, potentially represent a critical…

Large language model (LLM)-based computer-use agents represent a convergence of AI and OS capabilities, enabling natural language to control system- and application-level functions. However, due to LLMs' inherent uncertainty issues,…

Cryptography and Security · Computer Science 2026-01-15 Haochen Gong , Chenxiao Li , Rui Chang , Wenbo Shen

We present scPilot, the first systematic framework to practice omics-native reasoning: a large language model (LLM) converses in natural language while directly inspecting single-cell RNA-seq data and on-demand bioinformatics tools. scPilot…

Artificial Intelligence · Computer Science 2026-02-13 Yiming Gao , Zhen Wang , Jefferson Chen , Mark Antkowiak , Mengzhou Hu , JungHo Kong , Dexter Pratt , Jieyuan Liu , Enze Ma , Zhiting Hu , Eric P. Xing

Annotated data plays a critical role in Natural Language Processing (NLP) in training models and evaluating their performance. Given recent developments in Large Language Models (LLMs), models such as ChatGPT demonstrate zero-shot…

Computation and Language · Computer Science 2024-03-18 Minzhi Li , Taiwei Shi , Caleb Ziems , Min-Yen Kan , Nancy F. Chen , Zhengyuan Liu , Diyi Yang

Designing de novo proteins beyond those found in nature holds significant promise for advancements in both scientific and engineering applications. Current methodologies for protein design often rely on AI-based models, such as surrogate…

Soft Condensed Matter · Physics 2024-02-08 A. Ghafarollahi , M. J. Buehler

The advancement of single cell RNA-sequencing technologies has led to an explosion of cell type definitions across multiple organs and organisms. While standards for data and metadata intake are arising, organization of cell types has…

Large language models (LLMs) and vision-language models (VLMs) have the potential to transform biological research by enabling autonomous experimentation. Yet, their application remains constrained by rigid protocol design, limited…

Robotics · Computer Science 2025-07-03 Yibo Qiu , Zan Huang , Zhiyu Wang , Handi Liu , Yiling Qiao , Yifeng Hu , Shu'ang Sun , Hangke Peng , Ronald X Xu , Mingzhai Sun

Traditional image annotation tasks rely heavily on human effort for object selection and label assignment, making the process time-consuming and prone to decreased efficiency as annotators experience fatigue after extensive work. This paper…

Computer Vision and Pattern Recognition · Computer Science 2025-03-17 He Zhang , Xinyi Fu , John M. Carroll

With the rapid advancement of post-training techniques for reasoning and information seeking, large language models (LLMs) can incorporate a large quantity of retrieved knowledge to solve complex tasks. However, the limited context window…

Computation and Language · Computer Science 2026-04-21 Zijun Liu , Zhennan Wan , Peng Li , Ming Yan , Fei Huang , Yang Liu

Large Language Models (LLMs) have revolutionized software engineering (SE), showcasing remarkable proficiency in various coding tasks. Despite recent advancements that have enabled the creation of autonomous software agents utilizing LLMs…

Software Engineering · Computer Science 2025-09-08 Huy Nhat Phan , Tien N. Nguyen , Phong X. Nguyen , Nghi D. Q. Bui

Entity alignment (EA) aims to identify entities across different knowledge graphs (KGs) that refer to the same real-world object and plays a critical role in knowledge fusion and integration. Traditional EA methods mainly rely on knowledge…

Information Retrieval · Computer Science 2026-04-14 Yixuan Nan , Xixun Lin , Yanmin Shang , Ge Zhang , Zheng Fang , Fang Fang , Yanan Cao

Smart contracts are the backbone of the decentralized web, yet ensuring their functional correctness and security remains a critical challenge. While Large Language Models (LLMs) have shown promise in code generation, they often struggle…

Software Engineering · Computer Science 2026-02-02 Wei Chen , Zhiyuan Peng , Xin Yin , Chao Ni , Chenhao Ying , Bang Xie , Yuan Luo

Human placenta is a complex and heterogeneous organ interfacing between the mother and the fetus that supports fetal development. Alterations to placental structural components are associated with various pregnancy complications. To reveal…

Tissues and Organs · Quantitative Biology 2020-08-11 Hui Li , Qianhui Huang , Yu Liu , Lana X Garmire

Climate research is pivotal for mitigating global environmental crises, yet the accelerating volume of multi-scale datasets and the complexity of analytical tools have created significant bottlenecks, constraining scientific discovery to…

Artificial Intelligence · Computer Science 2026-04-28 Hao Wang , Jindong Han , Wei Fan , Hao Liu

Vehicle motion planning is an essential component of autonomous driving technology. Current rule-based vehicle motion planning methods perform satisfactorily in common scenarios but struggle to generalize to long-tailed situations.…

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