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Medical image segmentation is vital for clinical diagnosis, yet current deep learning methods often demand extensive expert effort, i.e., either through annotating large training datasets or providing prompts at inference time for each new…

Computer Vision and Pattern Recognition · Computer Science 2025-10-07 Xingjian Li , Qifeng Wu , Adithya S. Ubaradka , Yiran Ding , Colleen Que , Runmin Jiang , Jianhua Xing , Tianyang Wang , Min Xu

Vision foundation models like the Segment Anything Model (SAM), pretrained on large-scale natural image datasets, often struggle in medical image segmentation due to a lack of domain-specific adaptation. In clinical practice, fine-tuning…

Computer Vision and Pattern Recognition · Computer Science 2025-11-03 Zelin Liu , Sicheng Dong , Bocheng Li , Yixuan Yang , Jiacheng Ruan , Chenxu Zhou , Suncheng Xiang

Medical vision foundation models remain limited in downstream tasks, particularly volumetric medical image segmentation. While fine-tuning on labeled target-domain data improves performance, existing approaches typically rely on randomly…

Image and Video Processing · Electrical Eng. & Systems 2026-05-07 Jin Yang , Daniel S. Marcus , Aristeidis Sotiras

Promptable segmentation foundation models have emerged as a transformative approach to addressing the diverse needs in medical images, but most existing models require expensive computing, posing a big barrier to their adoption in clinical…

Medical image segmentation is an important analysis task in clinical practice and research. Deep learning has massively advanced the field, but current approaches are mostly based on models trained for a specific task. Training such models…

Image and Video Processing · Electrical Eng. & Systems 2025-12-18 Anwai Archit , Luca Freckmann , Constantin Pape

The Segment Anything Model (SAM) is a powerful foundation model that introduced revolutionary advancements in natural image segmentation. However, its performance remains sub-optimal when delineating the intricate structure of biomedical…

Image and Video Processing · Electrical Eng. & Systems 2023-10-05 Xiangru Li , Yifei Zhang , Liang Zhao

The Medical Segment Anything Model (MedSAM) has shown remarkable performance in medical image segmentation, drawing significant attention in the field. However, its sensitivity to varying prompt types and locations poses challenges. This…

Computer Vision and Pattern Recognition · Computer Science 2024-09-04 Nan Zhou , Ke Zou , Kai Ren , Mengting Luo , Linchao He , Meng Wang , Yidi Chen , Yi Zhang , Hu Chen , Huazhu Fu

Medical image segmentation is critical for clinical diagnosis, treatment planning, and monitoring, yet segmentation models often struggle with uncertainties stemming from occlusions, ambiguous boundaries, and variations in imaging devices.…

Computer Vision and Pattern Recognition · Computer Science 2026-01-05 Xiao Ma , Yuhui Tao , Zetian Zhang , Yuhan Zhang , Xi Wang , Sheng Zhang , Zexuan Ji , Yizhe Zhang , Qiang Chen , Guang Yang

Medical image segmentation has been traditionally approached by training or fine-tuning the entire model to cater to any new modality or dataset. However, this approach often requires tuning a large number of parameters during training.…

Computer Vision and Pattern Recognition · Computer Science 2024-08-14 Jay N. Paranjape , Shameema Sikder , S. Swaroop Vedula , Vishal M. Patel

Recent advances in foundation models have brought promising results in computer vision, including medical image segmentation. Fine-tuning foundation models on specific low-resource medical tasks has become a standard practice. However,…

Computer Vision and Pattern Recognition · Computer Science 2025-02-04 Jingyun Yang , Guoqing Zhang , Jingge Wang , Yang Li

Foundation models (FMs) such as CLIP and SAM have recently shown great promise in image segmentation tasks, yet their adaptation to 3D medical imaging-particularly for pathology detection and segmentation-remains underexplored. A critical…

Image and Video Processing · Electrical Eng. & Systems 2025-08-28 Sirui Li , Linkai Peng , Zheyuan Zhang , Gorkem Durak , Ulas Bagci

Foundation segmentation models such as SAM and SAM-2 perform well on natural images but struggle with brain MRIs where structures like the caudate and thalamus lack sharp boundaries and have low contrast. Rather than fine tune these models…

Image and Video Processing · Electrical Eng. & Systems 2025-11-26 Keith Moore

The Segment Anything Model (SAM) has demonstrated remarkable capabilities of scaled-up segmentation models, enabling zero-shot generalization across a variety of domains. By leveraging large-scale foundational models as pre-trained models,…

Computer Vision and Pattern Recognition · Computer Science 2023-08-29 Weijia Feng , Lingting Zhu , Lequan Yu

Segmentation is an important analysis task for biomedical images, enabling the study of individual organelles, cells or organs. Deep learning has massively improved segmentation methods, but challenges remain in generalization to new…

Computer Vision and Pattern Recognition · Computer Science 2025-06-03 Carolin Teuber , Anwai Archit , Constantin Pape

Test-time adaptation (TTA) seeks to tackle potential distribution shifts between training and testing data by adapting a given model w.r.t. any testing sample. This task is particularly important for deep models when the test environment…

Machine Learning · Computer Science 2022-06-01 Shuaicheng Niu , Jiaxiang Wu , Yifan Zhang , Yaofo Chen , Shijian Zheng , Peilin Zhao , Mingkui Tan

Medical image segmentation is crucial for clinical diagnosis. The Segmentation Anything Model (SAM) serves as a powerful foundation model for visual segmentation and can be adapted for medical image segmentation. However, medical imaging…

Image and Video Processing · Electrical Eng. & Systems 2024-11-07 Yuxi Liu , Guibo Luo , Yuesheng Zhu

Cancer detection and prognosis relies heavily on medical imaging, particularly CT and PET scans. Deep Neural Networks (DNNs) have shown promise in tumor segmentation by fusing information from these modalities. However, a critical…

Computer Vision and Pattern Recognition · Computer Science 2025-04-21 Numan Saeed , Shahad Hardan , Muhammad Ridzuan , Nada Saadi , Karthik Nandakumar , Mohammad Yaqub

Segment Anything Model (SAM) is one of the pioneering prompt-based foundation models for image segmentation and has been rapidly adopted for various medical imaging applications. However, in clinical settings, creating effective prompts is…

Computer Vision and Pattern Recognition · Computer Science 2024-11-26 Chengyin Li , Prashant Khanduri , Yao Qiang , Rafi Ibn Sultan , Indrin Chetty , Dongxiao Zhu

We propose a model-agnostic, progressive test-time energy adaptation approach for medical image segmentation. Maintaining model performance across diverse medical datasets is challenging, as distribution shifts arise from inconsistent…

Computer Vision and Pattern Recognition · Computer Science 2025-03-24 Xiaoran Zhang , Byung-Woo Hong , Hyoungseob Park , Daniel H. Pak , Anne-Marie Rickmann , Lawrence H. Staib , James S. Duncan , Alex Wong

Vision foundation models have demonstrated exceptional generalization capabilities in segmentation tasks for both generic and specialized images. However, a performance gap persists between foundation models and task-specific, specialized…

Computer Vision and Pattern Recognition · Computer Science 2025-01-31 Chengxi Zeng , David Smithard , Alberto M Gambaruto , Tilo Burghardt