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Recent advances in text-to-image generation with diffusion models present transformative capabilities in image quality. However, user controllability of the generated image, and fast adaptation to new tasks still remains an open challenge,…

Computer Vision and Pattern Recognition · Computer Science 2023-02-17 Omer Bar-Tal , Lior Yariv , Yaron Lipman , Tali Dekel

Recent advances in Diffusion Probabilistic Models (DPMs) have set new standards in high-quality image synthesis. Yet, controlled generation remains challenging, particularly in sensitive areas such as medical imaging. Medical images feature…

Computer Vision and Pattern Recognition · Computer Science 2025-10-09 Sarah Cechnicka , Matthew Baugh , Weitong Zhang , Mischa Dombrowski , Zhe Li , Johannes C. Paetzold , Candice Roufosse , Bernhard Kainz

Graph generation is a fundamental problem in graph learning with broad applications across Web-scale systems, knowledge graphs, and scientific domains such as drug and material discovery. Recent approaches leverage diffusion models for…

Machine Learning · Computer Science 2026-03-18 Jiachi Zhao , Zehong Wang , Yamei Liao , Chuxu Zhang , Yanfang Ye

Proteins adopt multiple structural conformations to perform their diverse biological functions, and understanding these conformations is crucial for advancing drug discovery. Traditional physics-based simulation methods often struggle with…

Biomolecules · Quantitative Biology 2025-03-14 Jiarui Lu , Xiaoyin Chen , Stephen Zhewen Lu , Chence Shi , Hongyu Guo , Yoshua Bengio , Jian Tang

Adapting text-to-image (T2I) latent diffusion models (LDMs) to video editing has shown strong visual fidelity and controllability, but challenges remain in maintaining causal relationships inherent to the video data generating process.…

Computer Vision and Pattern Recognition · Computer Science 2025-08-06 Nikos Spyrou , Athanasios Vlontzos , Paraskevas Pegios , Thomas Melistas , Nefeli Gkouti , Yannis Panagakis , Giorgos Papanastasiou , Sotirios A. Tsaftaris

Recent advancements in generative models have revolutionized the field of artificial intelligence, enabling the creation of highly-realistic and detailed images. In this study, we propose a novel Mask Conditional Text-to-Image Generative…

Computer Vision and Pattern Recognition · Computer Science 2024-10-02 Rami Skaik , Leonardo Rossi , Tomaso Fontanini , Andrea Prati

Continuous Conditional Generative Modeling (CCGM) estimates high-dimensional data distributions, such as images, conditioned on scalar continuous variables (aka regression labels). While Continuous Conditional Generative Adversarial…

Computer Vision and Pattern Recognition · Computer Science 2025-08-19 Xin Ding , Yongwei Wang , Kao Zhang , Z. Jane Wang

Code generation is increasingly critical for real-world applications. Still, diffusion-based large language models continue to struggle with this demand. Unlike free-form text, code requires syntactic precision; even minor structural…

Computation and Language · Computer Science 2026-01-07 Yiming Zeng , Jinghan Cao , Zexin Li , Yiming Chen , Tao Ren , Zhuochun Li , Dawei Xiang , Xidong Wu , Shangqian Gao , Tingting Yu

Diffusion probabilistic models have been shown to generate state-of-the-art results on several competitive image synthesis benchmarks but lack a low-dimensional, interpretable latent space, and are slow at generation. On the other hand,…

Machine Learning · Computer Science 2022-11-30 Kushagra Pandey , Avideep Mukherjee , Piyush Rai , Abhishek Kumar

The design of protein sequences with desired functionalities is a fundamental task in protein engineering. Deep generative methods, such as autoregressive models and diffusion models, have greatly accelerated the discovery of novel protein…

Machine Learning · Computer Science 2025-04-16 Zitai Kong , Yiheng Zhu , Yinlong Xu , Hanjing Zhou , Mingzhe Yin , Jialu Wu , Hongxia Xu , Chang-Yu Hsieh , Tingjun Hou , Jian Wu

Content is created for a well-defined purpose, often described by a metric or signal represented in the form of structured information. The relationship between the goal (metrics) of target content and the content itself is non-trivial.…

Computation and Language · Computer Science 2022-03-29 Navita Goyal , Roodram Paneri , Ayush Agarwal , Udit Kalani , Abhilasha Sancheti , Niyati Chhaya

The acquisition of annotated datasets with paired images and segmentation masks is a critical challenge in domains such as medical imaging, remote sensing, and computer vision. Manual annotation demands significant resources, faces ethical…

Computer Vision and Pattern Recognition · Computer Science 2025-03-26 Rupak Bose , Chinedu Innocent Nwoye , Aditya Bhat , Nicolas Padoy

Designing protein binders targeting specific sites, which requires to generate realistic and functional interaction patterns, is a fundamental challenge in drug discovery. Current structure-based generative models are limited in generating…

Machine Learning · Computer Science 2025-10-17 Zishen Zhang , Xiangzhe Kong , Wenbing Huang , Yang Liu

The biological functions of proteins often depend on dynamic structural ensembles. In this work, we develop a flow-based generative modeling approach for learning and sampling the conformational landscapes of proteins. We repurpose highly…

Biomolecules · Quantitative Biology 2024-09-04 Bowen Jing , Bonnie Berger , Tommi Jaakkola

Diffusion-based generative image compression has demonstrated remarkable potential for achieving realistic reconstruction at ultra-low bitrates. The key to unlocking this potential lies in making the entire compression process…

Computer Vision and Pattern Recognition · Computer Science 2026-03-26 Xihua Sheng , Lingyu Zhu , Tianyu Zhang , Dong Liu , Shiqi Wang , Jing Wang

Cardiac Magnetic Resonance (CMR) imaging is a vital non-invasive tool for diagnosing heart diseases and evaluating cardiac health. However, the limited availability of large-scale, high-quality CMR datasets poses a major challenge to the…

Computer Vision and Pattern Recognition · Computer Science 2025-05-07 Ziyu Li , Yujian Hu , Zhengyao Ding , Yiheng Mao , Haitao Li , Fan Yi , Hongkun Zhang , Zhengxing Huang

We present a novel character control framework that effectively utilizes motion diffusion probabilistic models to generate high-quality and diverse character animations, responding in real-time to a variety of dynamic user-supplied control…

Graphics · Computer Science 2024-04-24 Rui Chen , Mingyi Shi , Shaoli Huang , Ping Tan , Taku Komura , Xuelin Chen

Recently, the Diffusion Probabilistic Model (DPM)-based methods have achieved substantial success in the field of medical image segmentation. However, most of these methods fail to enable the diffusion model to learn edge features and…

Image and Video Processing · Electrical Eng. & Systems 2024-06-21 Tingwei Liu , Miao Zhang , Leiye Liu , Jialong Zhong , Shuyao Wang , Yongri Piao , Huchuan Lu

While significant progress has been achieved in multimodal facial generation using semantic masks and textual descriptions, conventional feature fusion approaches often fail to enable effective cross-modal interactions, thereby leading to…

Computer Vision and Pattern Recognition · Computer Science 2026-01-08 Yushe Cao , Dianxi Shi , Xing Fu , Xuechao Zou , Haikuo Peng , Xueqi Li , Chun Yu , Junliang Xing

Sequence generative models are transforming protein engineering. However, no principled framework exists for conditioning these models on auxiliary information, such as experimental data, without additional training of a generative model.…

Machine Learning · Computer Science 2026-01-19 Junhao Xiong , Ishan Gaur , Maria Lukarska , Hunter Nisonoff , Luke M. Oltrogge , David F. Savage , Jennifer Listgarten
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