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We develop a general analytical and numerical framework for estimating intra- and extra-neurite water fractions and diffusion coefficients, as well as neurite orientational dispersion, in each imaging voxel. By employing a set of rotational…
Purpose: To develop a deep network architecture that would achieve fully automated radiologist-level segmentation of cancers at breast MRI. Materials and Methods: In this retrospective study, 38229 examinations (composed of 64063 individual…
Adaptive radiotherapy is a growing field of study in cancer treatment due to it's objective in sparing healthy tissue. The standard of care in several institutions includes longitudinal cone-beam computed tomography (CBCT) acquisitions to…
In lung radiotherapy, the primary objective is to optimize treatment outcomes by minimizing exposure to healthy tissues while delivering the prescribed dose to the target volume. The challenge lies in accounting for lung tissue motion due…
Plastic scintillation detectors are increasingly used to measure dose distributions in the context of radiotherapy treatments. Their water-equivalence, real-time response and high spatial resolution distinguish them from traditional…
Purpose: Cell size is a fundamental characteristic of all tissues, and changes in cell size in cancer reflect tumor status and response to treatments, such as apoptosis and cell cycle arrest. Unfortunately, cell size can only be obtained by…
Proton therapy offers superior organ-at-risk sparing but is highly sensitive to anatomical changes, making accurate deformable image registration (DIR) across longitudinal CT scans essential. Conventional DIR methods are often too slow for…
Breast cancer screening, primarily conducted through mammography, is often supplemented with ultrasound for women with dense breast tissue. However, existing deep learning models analyze each modality independently, missing opportunities to…
Breast cancer is a significant public health concern and early detection is critical for triaging high risk patients. Sequential screening mammograms can provide important spatiotemporal information about changes in breast tissue over time.…
We propose a novel framework to learn the spatiotemporal variability in longitudinal 3D shape data sets, which contain observations of objects that evolve and deform over time. This problem is challenging since surfaces come with arbitrary…
To track tumors during surgery, information from preoperative CT scans is used to determine their position. However, as the surgeon operates, the tumor may be deformed which presents a major hurdle for accurately resecting the tumor, and…
Objective: In this work, we perform margin assessment of human breast tissue from optical coherence tomography (OCT) images using deep neural networks (DNNs). This work simulates an intraoperative setting for breast cancer lumpectomy.…
Purpose: This study quantifies the variation in dose-volume histogram (DVH) and normal tissue complication probability (NTCP) metrics for head-and-neck (HN) cancer patients when alternative organ-at-risk (OAR) delineations are used for…
Diffusion-weighted magnetic resonance imaging (DW-MRI) is a critical imaging method for capturing and modeling tissue microarchitecture at a millimeter scale. A common practice to model the measured DW-MRI signal is via fiber orientation…
Malignant and benign breast tumors present differently in their shape and size on sonography. Morphological information provided by tumor contours are important in clinical diagnosis. However, ultrasound images contain noises and tissue…
In this paper, an innovative microwave imaging (MI) approach for breast tumor diagnosis is proposed that employs a differential formulation of the inverse scattering problem (ISP) at hand to exploit arbitrary-fidelity priors on the…
A SPAMM tagged MRI methodology is presented allowing continuous (3.3-3.6 Hz) sampling of 3D dynamic soft tissue deformation using non-segmented 3D acquisitions. The 3D deformation is reconstructed by the combination of 3 mutually orthogonal…
Objective: To develop an automatic image normalization algorithm for intensity correction of images from breast dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) acquired by different MRI scanners with various imaging…
Intensity modulated radiotherapy (IMRT) is one of the most common modalities for treating cancer patients. One of the biggest challenges is precise treatment delivery that accounts for varying motion patterns originating from…
Melanoma brain metastases (MBM) are common and spatially heterogeneous lesions, complicating cohort-level analyses due to anatomical variability and differing MRI protocols. We propose a fully differentiable, deep-learning-based deformable…