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Dementia is under-recognized in the community, under-diagnosed by healthcare professionals, and under-coded in claims data. Information on cognitive dysfunction, however, is often found in unstructured clinician notes within medical records…

Dementia is a neurodegenerative disease that causes gradual cognitive impairment, which is very common in the world and undergoes a lot of research every year to prevent and cure it. It severely impacts the patient's ability to remember…

Dementia is a progressive neurological disorder that profoundly affects the daily lives of older adults, impairing abilities such as verbal communication and cognitive function. Early diagnosis is essential for enhancing both lifespan and…

Computational Engineering, Finance, and Science · Computer Science 2023-11-07 Kaiying Lin , Peter Washington

United States healthcare systems are struggling to meet the growing demand for neurological care, particularly in Alzheimer's disease and related dementias (ADRD). Generative AI built on language models (LLMs) now enables agentic AI systems…

We introduce Agentic Reasoning, a framework that enhances large language model (LLM) reasoning by integrating external tool-using agents. Agentic Reasoning dynamically leverages web search, code execution, and structured memory to address…

Artificial Intelligence · Computer Science 2025-07-16 Junde Wu , Jiayuan Zhu , Yuyuan Liu , Min Xu , Yueming Jin

Large language model (LLM) agents are constrained by limited context windows, necessitating external memory systems for long-term information understanding. Current memory-augmented agents typically depend on pre-defined instructions and…

Computation and Language · Computer Science 2025-10-01 Yu Wang , Ryuichi Takanobu , Zhiqi Liang , Yuzhen Mao , Yuanzhe Hu , Julian McAuley , Xiaojian Wu

Artificial intelligence (AI) is reshaping modern healthcare by advancing disease diagnosis, treatment decision-making, and biomedical research. Among AI technologies, large language models (LLMs) have become especially impactful, enabling…

Artificial Intelligence · Computer Science 2025-11-18 Zhengda Wang , Daqian Shi , Jingyi Zhao , Xiaolei Diao , Xiongfeng Tang , Yanguo Qin

The rapid evolution of Large Language Model (LLM) agents has necessitated robust memory systems to support cohesive long-term interaction and complex reasoning. Benefiting from the strong capabilities of LLMs, recent research focus has…

Artificial Intelligence · Computer Science 2026-04-16 Weiquan Huang , Zixuan Wang , Hehai Lin , Sudong Wang , Bo Xu , Qian Li , Beier Zhu , Linyi Yang , Chengwei Qin

Dementia care requires healthcare professionals to balance a patient's medical needs with a deep understanding of their personal needs, preferences, and emotional cues. However, current digital tools prioritise quantitative metrics over…

Human-Computer Interaction · Computer Science 2025-09-11 Rhiannon Owen , Jonathan C. Roberts

Early diagnosis of Alzheimer's Disease (AD) faces multiple data-related challenges, including high variability in patient data, limited access to specialized diagnostic tests, and overreliance on single-type indicators. These challenges are…

Quantitative Methods · Quantitative Biology 2025-03-05 Yizong Xing , Dhita Putri Pratama , Yuke Wang , Yufan Zhang , Brian E. Chapman

Large language models (LLMs) as autonomous agents offer a novel avenue for tackling real-world challenges through a knowledge-driven manner. These LLM-enhanced methodologies excel in generalization and interpretability. However, the…

Artificial Intelligence · Computer Science 2024-07-22 Kemou Jiang , Xuan Cai , Zhiyong Cui , Aoyong Li , Yilong Ren , Haiyang Yu , Hao Yang , Daocheng Fu , Licheng Wen , Pinlong Cai

Mental health issues, particularly depressive disorders, present significant challenges in contemporary society, necessitating the development of effective automated diagnostic methods. This paper introduces the Agent Mental Clinic (AMC), a…

Computation and Language · Computer Science 2024-10-10 Kunyao Lan , Bingrui Jin , Zichen Zhu , Siyuan Chen , Shu Zhang , Kenny Q. Zhu , Mengyue Wu

In remote healthcare monitoring, time series representation learning reveals critical patient behavior patterns from high-frequency data. This study analyzes home activity data from individuals living with dementia by proposing a two-stage,…

Machine Learning · Computer Science 2025-02-17 Jin Cui , Alexander Capstick , Payam Barnaghi , Gregory Scott

Since individuals may struggle to recall all life details and often confuse events, establishing a system to assist users in recalling forgotten experiences is essential. While numerous studies have proposed memory recall systems, these…

Computation and Language · Computer Science 2026-02-26 Chia Cheng Chang , An-Zi Yen , Hen-Hsen Huang , Hsin-Hsi Chen

Reminiscence therapy (RT) is a common non-pharmacological intervention in dementia care. Recent technology-mediated interventions have largely focused on people with dementia through solutions that replace human facilitators with…

Human-Computer Interaction · Computer Science 2026-02-20 Celeste Seah , Yoke Chuan Lee , Jung-Joo Lee , Ching-Chiuan Yen , Clement Zheng

Despite the significant progress of large language models (LLMs) in various tasks, they often produce factual errors due to their limited internal knowledge. Retrieval-Augmented Generation (RAG), which enhances LLMs with external knowledge…

Computation and Language · Computer Science 2024-10-10 Yuanjie Lyu , Zihan Niu , Zheyong Xie , Chao Zhang , Tong Xu , Yang Wang , Enhong Chen

The emergence of Large Language Models (LLMs) has significantly advanced natural language processing, but these models often generate factually incorrect information, known as "hallucination". Initial retrieval-augmented generation (RAG)…

Computation and Language · Computer Science 2024-11-12 Yujia Zhou , Zheng Liu , Zhicheng Dou

As the global burden of Alzheimer's disease (AD) continues to grow, early and accurate detection has become increasingly critical, especially in regions with limited access to advanced diagnostic tools. We propose BRAINS (Biomedical…

Machine Learning · Computer Science 2025-11-05 Rajan Das Gupta , Md Kishor Morol , Nafiz Fahad , Md Tanzib Hosain , Sumaya Binte Zilani Choya , Md Jakir Hossen

Personalized AI assistants often struggle to incorporate complex personal data and causal knowledge, leading to generic advice that lacks explanatory power. We propose REMI, a Causal Schema Memory architecture for a multimodal lifestyle…

Artificial Intelligence · Computer Science 2025-09-09 Vishal Raman , Vijai Aravindh R , Abhijith Ragav

Dementia encompasses a group of syndromes that impair cognitive functions such as memory, reasoning, and the ability to perform daily activities. As populations globally age, over 10 million new dementia diagnoses are reported annually.…

Audio and Speech Processing · Electrical Eng. & Systems 2026-04-24 Marko Niemelä , Mikaela von Bonsdorff , Sami Äyrämö , Tommi Kärkkäinen