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The inference of gene regulatory networks (GRNs) is a foundational stride towards deciphering the fundamentals of complex biological systems. Inferring a possible regulatory link between two genes can be formulated as a link prediction…

Machine Learning · Computer Science 2025-04-25 Binon Teji , Swarup Roy

The way we analyse clinical texts has undergone major changes over the last years. The introduction of language models such as BERT led to adaptations for the (bio)medical domain like PubMedBERT and ClinicalBERT. These models rely on large…

Computation and Language · Computer Science 2023-09-15 Tom van Sonsbeek , Xiantong Zhen , Marcel Worring

Thanks to the increasing availability of genomics and other biomedical data, many machine learning approaches have been proposed for a wide range of therapeutic discovery and development tasks. In this survey, we review the literature on…

Machine Learning · Computer Science 2021-05-05 Kexin Huang , Cao Xiao , Lucas M. Glass , Cathy W. Critchlow , Greg Gibson , Jimeng Sun

Vector representations have been pivotal in advancing natural language processing (NLP), with prior research focusing on embedding techniques for mathematical expressions using mathematically equivalent formulations. While effective, these…

Machine Learning · Computer Science 2025-03-11 Hongbo Zheng , Suyuan Wang , Neeraj Gangwar , Nickvash Kani

Disease forecasting models typically rely on a single data stream, making models brittle when histories are short or noisy. Recent top-performing models have shown that synthesizing multiple reporting systems for the same disease improves…

Machine Learning · Computer Science 2026-05-27 Lauren J Beesley , Alexander C Murph , Dave Osthus , Lauren A Castro

Intensive Care Units (ICU) require comprehensive patient data integration for enhanced clinical outcome predictions, crucial for assessing patient conditions. Recent deep learning advances have utilized patient time series data, and fusion…

Machine Learning · Computer Science 2023-11-14 Samyak Jain , Manuel Burger , Gunnar Rätsch , Rita Kuznetsova

Routine clinical visits of a patient produce not only image data, but also non-image data containing clinical information regarding the patient, i.e., medical data is multi-modal in nature. Such heterogeneous modalities offer different and…

Computer Vision and Pattern Recognition · Computer Science 2023-03-16 Sein Kim , Namkyeong Lee , Junseok Lee , Dongmin Hyun , Chanyoung Park

Gene expression data represents a unique challenge in predictive model building, because of the small number of samples $(n)$ compared to the huge amount of features $(p)$. This "$n<<p$" property has hampered application of deep learning…

Machine Learning · Statistics 2018-02-13 Yunchuan Kong , Tianwei Yu

Understanding how small molecules perturb gene expression is essential for uncovering drug mechanisms, predicting off-target effects, and identifying repurposing opportunities. While prior deep learning frameworks have integrated multimodal…

Machine Learning · Computer Science 2026-01-01 Pascal Passigan , Kevin Zhu , Angelina Ning

Knowledge graphs represent facts about real-world entities. Most of these facts are defined as positive statements. The negative statements are scarce but highly relevant under the open-world assumption. Furthermore, they have been…

Artificial Intelligence · Computer Science 2023-11-16 Rita T. Sousa , Sara Silva , Catia Pesquita

A graph neural network (GNN) for image understanding based on multiple cues is proposed in this paper. Compared to traditional feature and decision fusion approaches that neglect the fact that features can interact and exchange information,…

Computer Vision and Pattern Recognition · Computer Science 2020-03-02 Xin Guo , Luisa F. Polania , Bin Zhu , Charles Boncelet , Kenneth E. Barner

Knowledge graphs are an efficient method for representing and connecting information across various concepts, useful in reasoning, question answering, and knowledge base completion tasks. They organize data by linking points, enabling…

Artificial Intelligence · Computer Science 2025-02-25 Saher Mohamed , Kirollos Farah , Abdelrahman Lotfy , Kareem Rizk , Abdelrahman Saeed , Shahenda Mohamed , Ghada Khouriba , Tamer Arafa

Drug repurposing is more relevant than ever due to drug development's rising costs and the need to respond to emerging diseases quickly. Knowledge graph embedding enables drug repurposing using heterogeneous data sources combined with…

Medical diagnosis is the process of making a prediction of the disease a patient is likely to have, given a set of symptoms and observations. This requires extensive expert knowledge, in particular when covering a large variety of diseases.…

Artificial Intelligence · Computer Science 2022-04-29 Niclas Heilig , Jan Kirchhoff , Florian Stumpe , Joan Plepi , Lucie Flek , Heiko Paulheim

The ubiquity of machine learning, particularly deep learning, applied to graphs is evident in applications ranging from cheminformatics (drug discovery) and bioinformatics (protein interaction prediction) to knowledge graph-based query…

Databases · Computer Science 2025-02-04 Arijit Khan , Xiangyu Ke , Yinghui Wu

Knowledge graphs are used to represent relational information in terms of triples. To enable learning about domains, embedding models, such as tensor factorization models, can be used to make predictions of new triples. Often there is…

Machine Learning · Computer Science 2018-12-11 Bahare Fatemi , Siamak Ravanbakhsh , David Poole

To leverage machine learning in any decision-making process, one must convert the given knowledge (for example, natural language, unstructured text) into representation vectors that can be understood and processed by machine learning model…

Machine Learning · Computer Science 2023-07-11 Shibo Yao

Pathology diagnosis based on EEG signals and decoding brain activity holds immense importance in understanding neurological disorders. With the advancement of artificial intelligence methods and machine learning techniques, the potential…

In this thesis, we study the problem of feature learning on heterogeneous knowledge graphs. These features can be used to perform tasks such as link prediction, classification and clustering on graphs. Knowledge graphs provide rich…

Machine Learning · Computer Science 2018-09-11 Sebastian Bischoff

Biological systems are governed by structured molecular interactions, where pathways, regulatory circuits, and functional gene relationships shape cellular behavior and disease progression. Much of this knowledge is naturally represented as…

Machine Learning · Computer Science 2026-05-26 Yuwei Xue , Sakib Mostafa , James Zou , Joseph Liao , Maximilian Diehn , Ash A. Alizadeh , Lei Xing , Md. Tauhidul Islam