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Proteins inherently possess a consistent sequence-structure duality. The abundance of protein sequence data, which can be readily represented as discrete tokens, has driven fruitful developments in protein language models (pLMs). A key…

Computational Engineering, Finance, and Science · Computer Science 2026-05-29 Yi Zhou , Haohao Qu , Yunqing Liu , Shanru Lin , Le Song , Wenqi Fan

For protein sequence datasets, unlabeled data has greatly outpaced labeled data due to the high cost of wet-lab characterization. Recent deep-learning approaches to protein prediction have shown that pre-training on unlabeled data can yield…

Machine Learning · Computer Science 2020-12-02 Pascal Sturmfels , Jesse Vig , Ali Madani , Nazneen Fatema Rajani

Panoptic and instance segmentation networks are often trained with specialized object detection modules, complex loss functions, and ad-hoc post-processing steps to manage the permutation-invariance of the instance masks. This work builds…

Computer Vision and Pattern Recognition · Computer Science 2024-07-17 Wouter Van Gansbeke , Bert De Brabandere

To successfully apply trained neural network models to new domains, powerful transfer learning solutions are essential. We propose to introduce a novel cross-domain latent modulation mechanism to a variational autoencoder framework so as to…

Machine Learning · Computer Science 2024-02-01 Jinyong Hou , Jeremiah D. Deng , Stephen Cranefield , Xuejie Din

Learning effective protein representations is critical in a variety of tasks in biology such as predicting protein functions. Recent sequence representation learning methods based on Protein Language Models (PLMs) excel in sequence-based…

Quantitative Methods · Quantitative Biology 2023-10-19 Zuobai Zhang , Chuanrui Wang , Minghao Xu , Vijil Chenthamarakshan , Aurélie Lozano , Payel Das , Jian Tang

This paper introduces a novel hierarchical autoencoder that maps 3D models into a highly compressed latent space. The hierarchical autoencoder is specifically designed to tackle the challenges arising from large-scale datasets and…

Computer Vision and Pattern Recognition · Computer Science 2024-10-03 Biao Zhang , Peter Wonka

The analysis of data sets arising from multiple sensors has drawn significant research attention over the years. Traditional methods, including kernel-based methods, are typically incapable of capturing nonlinear geometric structures. We…

Data Analysis, Statistics and Probability · Physics 2017-08-04 Ronen Talmon , Hau-tieng Wu

Self-supervised learning has proved effective for skeleton-based human action understanding. However, previous works either rely on contrastive learning that suffers false negative problems or are based on reconstruction that learns too…

Computer Vision and Pattern Recognition · Computer Science 2024-09-17 Lehong Wu , Lilang Lin , Jiahang Zhang , Yiyang Ma , Jiaying Liu

Latent diffusion models (LDMs) enable high-fidelity synthesis by operating in learned latent spaces. However, training state-of-the-art LDMs requires complex staging: a tokenizer must be trained first, before the diffusion model can be…

Computer Vision and Pattern Recognition · Computer Science 2026-03-24 Shivam Duggal , Xingjian Bai , Zongze Wu , Richard Zhang , Eli Shechtman , Antonio Torralba , Phillip Isola , William T. Freeman

While many unsupervised learning models focus on one family of tasks, either generative or discriminative, we explore the possibility of a unified representation learner: a model which uses a single pre-training stage to address both…

Computer Vision and Pattern Recognition · Computer Science 2023-07-18 Soumik Mukhopadhyay , Matthew Gwilliam , Vatsal Agarwal , Namitha Padmanabhan , Archana Swaminathan , Srinidhi Hegde , Tianyi Zhou , Abhinav Shrivastava

Latent representation learned from multi-layered neural networks via hierarchical feature abstraction enables recent success of deep learning. Under the deep learning framework, generalization performance highly depends on the learned…

Machine Learning · Computer Science 2016-11-07 Hyo-Eun Kim , Sangheum Hwang , Kyunghyun Cho

We tackle the problem disentangling the latent space of an autoencoder in order to separate labelled attribute information from other characteristic information. This then allows us to change selected attributes while preserving other…

Machine Learning · Computer Science 2020-08-18 Xiao Li , Chenghua Lin , Ruizhe Li , Chaozheng Wang , Frank Guerin

When Masked Diffusion Models (MDMs) generate sequences through iterative refinement, the rich internal computation over masked positions is discarded, forcing every subsequent refinement step to recompute the valuable internal information…

Semantic segmentation is essential in computer vision for various applications, yet traditional approaches face significant challenges, including the high cost of annotation and extensive training for supervised learning. Additionally, due…

Computer Vision and Pattern Recognition · Computer Science 2024-03-19 Yasufumi Kawano , Yoshimitsu Aoki

Diffusion models are primarily trained for image synthesis, yet their denoising trajectories encode rich, spatially aligned visual priors. In this paper, we demonstrate that these priors can be utilized for text-conditioned semantic and…

Computer Vision and Pattern Recognition · Computer Science 2026-04-28 Haoxiao Wang , Antao Xiang , Haiyang Sun , Peilin Sun , Changhao Pan , Yifu Chen , Minjie Hong , Weijie Wang , Shuang Chen , Yue Chen , Zhou Zhao

Autoencoders receive latent models of input data. It was shown in recent works that they also estimate probability density functions of the input. This fact makes using the Bayesian decision theory possible. If we obtain latent models of…

Computer Vision and Pattern Recognition · Computer Science 2018-11-07 Vasily Morzhakov

The predominant success of diffusion models in generative modeling has spurred significant interest in understanding their theoretical foundations. In this work, we propose a feature learning framework aimed at analyzing and comparing the…

Machine Learning · Statistics 2025-03-04 Andi Han , Wei Huang , Yuan Cao , Difan Zou

The steep computational cost of diffusion models at inference hinders their use as fast physics emulators. In the context of image and video generation, this computational drawback has been addressed by generating in the latent space of an…

Machine Learning · Computer Science 2025-11-04 François Rozet , Ruben Ohana , Michael McCabe , Gilles Louppe , François Lanusse , Shirley Ho

Temporal abstraction and efficient planning pose significant challenges in offline reinforcement learning, mainly when dealing with domains that involve temporally extended tasks and delayed sparse rewards. Existing methods typically plan…

Machine Learning · Computer Science 2023-10-03 Wenhao Li

By decomposing the image formation process into a sequential application of denoising autoencoders, diffusion models (DMs) achieve state-of-the-art synthesis results on image data and beyond. Additionally, their formulation allows for a…

Computer Vision and Pattern Recognition · Computer Science 2022-04-14 Robin Rombach , Andreas Blattmann , Dominik Lorenz , Patrick Esser , Björn Ommer
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