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Medicine is inherently a multimodal discipline. Medical images can reflect the pathological changes of cancer and tumors, while the expression of specific genes can influence their morphological characteristics. However, most deep learning…

Computer Vision and Pattern Recognition · Computer Science 2024-06-04 Jiaying Zhou , Mingzhou Jiang , Junde Wu , Jiayuan Zhu , Ziyue Wang , Yueming Jin

Drug Mechanism of Action (MoA) mainly investigates how drug molecules interact with cells, which is crucial for drug discovery and clinical application. Recently, deep learning models have been used to recognize MoA by relying on…

Computer Vision and Pattern Recognition · Computer Science 2025-07-11 Fengqian Pang , Chunyue Lei , Hongfei Zhao , Chenghao Liu , Zhiqiang Xing , Huafeng Wang , Chuyang Ye

The scarcity of annotated data has sparked significant interest in unsupervised pre-training methods that leverage medical reports as auxiliary signals for medical visual representation learning. However, existing research overlooks the…

Computer Vision and Pattern Recognition · Computer Science 2024-02-06 Zhe Li , Laurence T. Yang , Bocheng Ren , Xin Nie , Zhangyang Gao , Cheng Tan , Stan Z. Li

Multimodal sentiment analysis (MSA) is a fundamental complex research problem due to the heterogeneity gap between different modalities and the ambiguity of human emotional expression. Although there have been many successful attempts to…

Machine Learning · Computer Science 2022-07-05 Jiahao Zheng , Sen Zhang , Xiaoping Wang , Zhigang Zeng

Contrastive learning based vision-language joint pre-training has emerged as a successful representation learning strategy. In this paper, we present a prototype representation learning framework incorporating both global and local…

Computer Vision and Pattern Recognition · Computer Science 2024-03-12 Pujin Cheng , Li Lin , Junyan Lyu , Yijin Huang , Wenhan Luo , Xiaoying Tang

Machine learning (ML) is increasingly used to support decision-making in the healthcare sector. While ML approaches provide promising results with regard to their classification performance, most share a central limitation, namely their…

The development of therapeutic antibodies heavily relies on accurate predictions of how antigens will interact with antibodies. Existing computational methods in antibody design often overlook crucial conformational changes that antigens…

Quantitative Methods · Quantitative Biology 2025-03-05 Cheng Tan , Yijie Zhang , Zhangyang Gao , Yufei Huang , Haitao Lin , Lirong Wu , Fandi Wu , Mathieu Blanchette , Stan. Z. Li

Predicting the binding affinity between antigens and antibodies is fundamental to drug discovery and vaccine development. Traditional computational approaches often rely on experimentally determined 3D structures, which are scarce and…

Machine Learning · Computer Science 2025-12-29 Aicha Boutorh , Soumia Bouyahiaoui , Sara Belhadj , Nour El Yakine Guendouz , Manel Kara Laouar

In the field of multimodal large language models (MLLMs), common methods typically involve unfreezing the language model during training to foster profound visual understanding. However, the fine-tuning of such models with vision-language…

Artificial Intelligence · Computer Science 2025-04-16 Bin Wang , Chunyu Xie , Dawei Leng , Yuhui Yin

Adversarial attacks (AAs) pose a significant threat to the reliability and robustness of deep neural networks. While the impact of these attacks on model predictions has been extensively studied, their effect on the learned representations…

Machine Learning · Computer Science 2024-03-26 Georgii Mikriukov , Gesina Schwalbe , Franz Motzkus , Korinna Bade

In recent years, artificial intelligence has played an important role on accelerating the whole process of drug discovery. Various of molecular representation schemes of different modals (e.g. textual sequence or graph) are developed. By…

Machine Learning · Computer Science 2022-11-28 Tianyu Wu , Yang Tang , Qiyu Sun , Luolin Xiong

This paper introduces a novel framework that accelerates the discovery of actionable relationships in high-dimensional temporal data by integrating machine learning (ML), explainable AI (XAI), and natural language processing (NLP) to…

Machine Learning · Computer Science 2025-06-09 Jiztom Kavalakkatt Francis , Matthew J Darr

Learning spatial-temporal relation among multiple actors is crucial for group activity recognition. Different group activities often show the diversified interactions between actors in the video. Hence, it is often difficult to model…

Computer Vision and Pattern Recognition · Computer Science 2022-04-07 Mingfei Han , David Junhao Zhang , Yali Wang , Rui Yan , Lina Yao , Xiaojun Chang , Yu Qiao

In the health domain, decisions are often based on different data modalities. Thus, when creating prediction models, multimodal fusion approaches that can extract and combine relevant features from different data modalities, can be highly…

Artificial Intelligence · Computer Science 2024-02-20 Mafalda Malafaia , Thalea Schlender , Peter A. N. Bosman , Tanja Alderliesten

In facial action unit (AU) recognition tasks, regional feature learning and AU relation modeling are two effective aspects which are worth exploring. However, the limited representation capacity of regional features makes it difficult for…

Computer Vision and Pattern Recognition · Computer Science 2021-02-25 Jingwei Yan , Boyuan Jiang , Jingjing Wang , Qiang Li , Chunmao Wang , Shiliang Pu

Self-supervised learning has recently gained growing interest in molecular modeling for scientific tasks such as AI-assisted drug discovery. Current studies consider leveraging both 2D and 3D molecular structures for representation…

Machine Learning · Computer Science 2023-10-10 Qiying Yu , Yudi Zhang , Yuyan Ni , Shikun Feng , Yanyan Lan , Hao Zhou , Jingjing Liu

Unified multimodal models for image generation and understanding represent a significant step toward AGI and have attracted widespread attention from researchers. The main challenge of this task lies in the difficulty in establishing an…

Computer Vision and Pattern Recognition · Computer Science 2026-05-13 Dian Zheng , Manyuan Zhang , Hongyu Li , Kai Zou , Hongbo Liu , Ziyu Guo , Kaituo Feng , Yexin Liu , Ying Luo , Hongsheng Li

Large multimodal model-based Multi-Agent Systems (MASs) enable collaborative complex problem solving through specialized agents. However, MASs are vulnerable to infectious jailbreak, where compromising a single agent can spread to others,…

Artificial Intelligence · Computer Science 2026-05-15 Yue Ma , Ziyuan Yang , Yi Zhang

Investigating children's embodied learning in mixed-reality environments, where they collaboratively simulate scientific processes, requires analyzing complex multimodal data to interpret their learning and coordination behaviors. Learning…

This paper presents a simple yet effective two-stage framework for semi-supervised medical image segmentation. Unlike prior state-of-the-art semi-supervised segmentation methods that predominantly rely on pseudo supervision directly on…

Computer Vision and Pattern Recognition · Computer Science 2023-08-01 Huimin Wu , Xiaomeng Li , Kwang-Ting Cheng
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