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Purpose: To develop and evaluate an automated system for extracting structured clinical information from unstructured radiology and pathology reports using open-weights large language models (LMs) and retrieval augmented generation (RAG),…

In this work we explore the performance and behavior of reasoning large language models to autonomously optimize atomic layer deposition (ALD) processes. In the ALD process optimization task, an agent built on top of a reasoning LLM has to…

Materials Science · Physics 2026-01-16 Angel Yanguas-Gil

Large language models (LLMs) are revolutionizing self driving laboratories (SDLs) for materials research, promising unprecedented acceleration of scientific discovery. However, current SDL implementations rely on rigid protocols that fail…

Low-Rank Adaptation (LoRA) has become a widely adopted parameter-efficient fine-tuning method for large language models, with its effectiveness largely influenced by the allocation of ranks and scaling factors, as well as initialization.…

Computation and Language · Computer Science 2026-04-21 Weicheng Lin , Yi Zhang , Jiawei Dang , Liang-Jie Zhang

Latent Dirichlet Allocation (LDA) is a popular topic modeling technique for hidden semantic discovery of text data and serves as a fundamental tool for text analysis in various applications. However, the LDA model as well as the training…

Machine Learning · Computer Science 2020-10-12 Fangyuan Zhao , Xuebin Ren , Shusen Yang , Qing Han , Peng Zhao , Xinyu Yang

Despite the impressive capabilities of Large Language Models (LLMs), existing Conversational Health Agents (CHAs) remain static and brittle, incapable of adaptive multi-turn reasoning, symptom clarification, or transparent decision-making.…

Computation and Language · Computer Science 2025-07-11 Xinyi Liu , Dachun Sun , Yi R. Fung , Dilek Hakkani-Tür , Tarek Abdelzaher

Anatomical changes during intensity-modulated proton therapy (IMPT) for head-and-neck cancer (HNC) can shift Bragg peaks, risking tumor underdosing and organ-at-risk overdosing. Treatment replanning is often required to maintain clinically…

Medical Physics · Physics 2025-08-13 Malvern Madondo , Yuan Shao , Yingzi Liu , Jun Zhou , Xiaofeng Yang , Zhen Tian

With the rapid advancement of large language models (LLMs), their deployment in real-world applications has become increasingly widespread. LLMs are expected to deliver robust performance across diverse tasks, user preferences, and…

Computation and Language · Computer Science 2025-11-21 Wei Xia , Zhi-Hong Deng

Seed implant brachytherapy (SIBT) is an effective cancer treatment modality; however, clinical planning often relies on manual adjustment of objective function weights, leading to inefficiencies and suboptimal results. This study proposes…

Medical Physics · Physics 2025-09-11 Zhuo Xiao , Qinglong Yao , Jingjing Wang , Fugen Zhou , Bo Liu , Haitao Sun , Zhe Ji , Yuliang Jiang , Junjie Wang , Qiuwen Wu

Curation is a significant barrier to using 'big data' radiotherapy planning databases of 100,000+ patients. Anatomic site stratification is essential for downstream analyses, but current methods rely on inconsistent plan labels or target…

Medical Physics · Physics 2026-03-02 Justin Hink , Yasin Abdulkadir , Jack Neylon , James Lamb

This paper presents a novel application of large language models (LLMs) to enhance user comprehension of privacy policies through an interactive dialogue agent. We demonstrate that LLMs significantly outperform traditional models in tasks…

Human-Computer Interaction · Computer Science 2024-10-17 Bolun Sun , Yifan Zhou , Haiyun Jiang

Background: Clinical documentation represents a significant burden for healthcare providers, with physicians spending up to 2 hours daily on administrative tasks. Recent advances in large language models (LLMs) offer promising solutions,…

Computation and Language · Computer Science 2025-07-08 Johnson Thomas , Ayush Mudgal , Wendao Liu , Nisten Tahiraj , Zeeshaan Mohammed , Dhruv Diddi

Traditionally, optimization of radiation therapy (RT) treatment plans has been done before the initiation of RT course, using population-wide estimates for patients' response to therapy. However, recent technological advancements have…

Medical Physics · Physics 2021-02-15 Stefan C. M. ten Eikelder , Ali Ajdari , Thomas Bortfeld , Dick den Hertog

The predicted increase in the number of patients receiving radiation therapy (RT) to treat cancer calls for an optimized use of resources. To manually schedule patients on the linear accelerators delivering RT is a time-consuming and…

Optimization and Control · Mathematics 2023-03-29 Sara Frimodig , Carole Mercier , Geert De Kerf

Large Language Models (LLMs) are increasingly integrating memory functionalities to provide personalized and context-aware interactions. However, user understanding, practices and expectations regarding these memory systems are not yet well…

Human-Computer Interaction · Computer Science 2025-08-12 Shuning Zhang , Rongjun Ma , Ying Ma , Shixuan Li , Yiqun Xu , Xin Yi , Hewu Li

Purpose: Various dose calculation algorithms are available for radiation therapy for cancer patients. However, these algorithms are faced with the tradeoff between efficiency and accuracy. The fast algorithms are generally less accurate,…

Medical Physics · Physics 2020-07-01 Yixun Xing , Dan Nguyen , Weiguo Lu , Ming Yang , Steve Jiang

Large language models (LLMs) have shown impressive capabilities in natural language processing tasks, including dialogue generation. This research aims to conduct a novel comparative analysis of two prominent techniques, fine-tuning with…

The performance of large language models (LLMs) depends on how they are prompted, with choices spanning both the high-level prompting pattern (e.g., Zero-Shot, CoT, ReAct, ReWOO) and the specific prompt content (instructions and few-shot…

Machine Learning · Computer Science 2025-11-05 Claudio Spiess , Mandana Vaziri , Louis Mandel , Martin Hirzel

The pursuit of human-level artificial intelligence (AI) has significantly advanced the development of autonomous agents and Large Language Models (LLMs). LLMs are now widely utilized as decision-making agents for their ability to interpret…

Hyperparameter optimization is critical in modern machine learning, requiring expert knowledge, numerous trials, and high computational and human resources. Despite the advancements in Automated Machine Learning (AutoML), challenges in…

Machine Learning · Computer Science 2025-02-27 Siyi Liu , Chen Gao , Yong Li
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