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Purpose: In high-dose-rate (HDR) prostate brachytherapy procedures, the pattern of needle placement solely relies on physician experience. We investigated the feasibility of using reinforcement learning (RL) to provide needle positions and…

Medical Physics · Physics 2025-06-12 Tonghe Wang , Yining Feng , Xiaofeng Yang

Radiotherapy treatment for prostate cancer relies on computed tomography (CT) and/or magnetic resonance imaging (MRI) for segmentation of target volumes and organs at risk (OARs). Manual segmentation of these volumes is regarded as the gold…

Fine-tuning large language models (LLMs) to align with human preferences has driven the success of systems such as Gemini and ChatGPT. However, approaches like Reinforcement Learning from Human Feedback (RLHF) remain computationally…

Machine Learning · Computer Science 2026-05-25 Miria Feng , Mert Pilanci

Deep learning (DL) has made notable progress in addressing complex radio access network control challenges that conventional analytic methods have struggled to solve. However, DL has shown limitations in solving constrained NP-hard problems…

Systems and Control · Electrical Eng. & Systems 2025-02-05 Hyeonho Noh , Byonghyo Shim , Hyun Jong Yang

Multi-agent settings are quickly gathering importance in machine learning. This includes a plethora of recent work on deep multi-agent reinforcement learning, but also can be extended to hierarchical RL, generative adversarial networks and…

Artificial Intelligence · Computer Science 2018-09-21 Jakob N. Foerster , Richard Y. Chen , Maruan Al-Shedivat , Shimon Whiteson , Pieter Abbeel , Igor Mordatch

Recent clinical studies suggest that the efficacy of hormone therapy for prostate cancer depends on the characteristics of individual patients. In this paper, we develop a computational framework for identifying patient-specific androgen…

Quantitative Methods · Quantitative Biology 2015-05-20 Bing Liu , Soonho Kong , Sicun Gao , Paolo Zuliani , Edmund M. Clarke

With the rapid advancement of Large Language Models (LLMs), LLM-based agents exhibit exceptional abilities in understanding and generating natural language, enabling human-like collaboration and information transmission in LLM-based…

Artificial Intelligence · Computer Science 2025-10-07 Hailong Yang , Renhuo Zhao , Guanjin Wang , Zhaohong Deng

Personalized Large Language Models (PLLMs) aim to align model outputs with individual user preferences, a crucial capability for user-centric applications. However, the prevalent approach of fine-tuning a separate module for each user faces…

Computation and Language · Computer Science 2025-11-27 Xiaopeng Li , Yuanjin Zheng , Wanyu Wang , wenlin zhang , Pengyue Jia , Yiqi Wang , Maolin Wang , Xuetao Wei , Xiangyu Zhao

Large Language Models (LLMs) have shown remarkable capabilities in natural language tasks requiring complex reasoning, yet their application in agentic, multi-step reasoning within interactive environments remains a difficult challenge.…

Artificial Intelligence · Computer Science 2024-08-15 Pranav Putta , Edmund Mills , Naman Garg , Sumeet Motwani , Chelsea Finn , Divyansh Garg , Rafael Rafailov

The applicability of Large Language Models (LLMs) in temporal reasoning tasks over data that is not present during training is still a field that remains to be explored. In this paper we work on this topic, focusing on structured and…

Computation and Language · Computer Science 2025-12-03 Alfredo Garrachón Ruiz , Tomás de la Rosa , Daniel Borrajo

Vision Language Models (VLMs) have recently been leveraged to generate robotic actions, forming Vision-Language-Action (VLA) models. However, directly adapting a pretrained VLM for robotic control remains challenging, particularly when…

This research paper investigates the application of Large Language Models (LLMs) in healthcare, specifically focusing on enhancing medical decision support through Retrieval-Augmented Generation (RAG) integrated with hospital-specific data…

Computation and Language · Computer Science 2025-05-07 Mohammad Shoaib Ansari , Mohd Sohail Ali Khan , Shubham Revankar , Aditya Varma , Anil S. Mokhade

We primarily focus on the field of large language models (LLMs) for recommendation, which has been actively explored recently and poses a significant challenge in effectively enhancing recommender systems with logical reasoning abilities…

Information Retrieval · Computer Science 2024-08-13 Jiachen Zhu , Jianghao Lin , Xinyi Dai , Bo Chen , Rong Shan , Jieming Zhu , Ruiming Tang , Yong Yu , Weinan Zhang

To accelerate mechanical design and enhance design quality and innovation, we present a Multidisciplinary Design and Optimization (MDO) Agent driven by Large Language Models (LLMs). The agent semi-automates the end-to-end workflow by…

Human-Computer Interaction · Computer Science 2025-11-25 Bingkun Guo , Wentian Li , Xiaojian Liu , Jiaqi Luo , Zibin Yu , Dalong Dong , Shuyou Zhang , Yiming Zhang

Background: The radiation oncology clinical practice involves many steps relying on the dynamic interplay of abundant text data. Large language models have displayed remarkable capabilities in processing complex text information. But their…

Deep learning-based automated contouring and treatment planning has been proven to improve the efficiency and accuracy of radiotherapy. However, conventional radiotherapy treatment planning process has the automated contouring and treatment…

Medical Physics · Physics 2024-12-02 Sangwook Kim , Aly Khalifa , Thomas G. Purdie , Chris McIntosh

Recently, reinforcement learning (RL) has been applied to task-oriented dialogue systems by using latent actions to solve shortcomings of supervised learning (SL). In this paper, we propose a multi-domain task-oriented dialogue system,…

Computation and Language · Computer Science 2021-07-08 Hyunmin Jeon , Gary Geunbae Lee

Thematic analysis (TA) is a widely used qualitative approach for uncovering latent meanings in unstructured text data. TA provides valuable insights in healthcare but is resource-intensive. Large Language Models (LLMs) have been introduced…

Human-Computer Interaction · Computer Science 2025-03-27 Huimin Xu , Seungjun Yi , Terence Lim , Jiawei Xu , Andrew Well , Carlos Mery , Aidong Zhang , Yuji Zhang , Heng Ji , Keshav Pingali , Yan Leng , Ying Ding

In complex clinical decision-making, clinicians must often track a variety of competing metrics defined by aim (ideal) and limit (strict) thresholds. Sifting through these high-dimensional tradeoffs to infer the optimal patient-specific…

Machine Learning · Computer Science 2026-02-17 Edward Chen , Natalie Dullerud , Pang Wei Koh , Thomas Niedermayr , Elizabeth Kidd , Sanmi Koyejo , Carlos Guestrin

Autonomous driving demands safe motion planning, especially in critical "long-tail" scenarios. Recent end-to-end autonomous driving systems leverage large language models (LLMs) as planners to improve generalizability to rare events.…

Computer Vision and Pattern Recognition · Computer Science 2025-01-17 Deepti Hegde , Rajeev Yasarla , Hong Cai , Shizhong Han , Apratim Bhattacharyya , Shweta Mahajan , Litian Liu , Risheek Garrepalli , Vishal M. Patel , Fatih Porikli