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Deep networks are prone to performance degradation when there is a domain shift between the source (training) data and target (test) data. Recent test-time adaptation methods update batch normalization layers of pre-trained source models…

Despite their recent success, deep neural networks continue to perform poorly when they encounter distribution shifts at test time. Many recently proposed approaches try to counter this by aligning the model to the new distribution prior to…

Deep learning (DL) has shown remarkable success in various medical imaging data analysis applications. However, it remains challenging for DL models to achieve good generalization, especially when the training and testing datasets are…

We propose a test-time adaptation method for cross-domain image segmentation. Our method is simple: Given a new unseen instance at test time, we adapt a pre-trained model by conducting instance-specific BatchNorm (statistics) calibration.…

Machine learning algorithms have achieved remarkable success across various disciplines, use cases and applications, under the prevailing assumption that training and test samples are drawn from the same distribution. Consequently, these…

Deep neural networks have useful applications in many different tasks, however their performance can be severely affected by changes in the data distribution. For example, in the biomedical field, their performance can be affected by…

For medical image analysis, segmentation models trained on one or several domains lack generalization ability to unseen domains due to discrepancies between different data acquisition policies. We argue that the degeneration in segmentation…

Cardiac segmentation is in great demand for clinical practice. Due to the enormous labor of manual delineation, unsupervised segmentation is desired. The ill-posed optimization problem of this task is inherently challenging, requiring…

Test-time adaptation (TTA) aims to improve model generalizability when test data diverges from training distribution, offering the distinct advantage of not requiring access to training data and processes, especially valuable in the context…

Electroencephalography (EEG) foundation models have shown strong potential for learning generalizable representations from large-scale neural data, yet their clinical deployment is hindered by distribution shifts across clinical settings,…

Many segmentation tasks for biomedical images can be modeled as the minimization of an energy function and solved by a class of max-flow and min-cut optimization algorithms. However, the segmentation accuracy is sensitive to the contrasting…

Deep learning-based models in medical imaging often struggle to generalize effectively to new scans due to data heterogeneity arising from differences in hardware, acquisition parameters, population, and artifacts. This limitation presents…

We propose to adapt segmentation networks with a constrained formulation, which embeds domain-invariant prior knowledge about the segmentation regions. Such knowledge may take the form of simple anatomical information, e.g., structure size…

Deep learning algorithms have demonstrated tremendous success on challenging medical imaging problems. However, post-deployment, these algorithms are susceptible to data distribution variations owing to \emph{limited data issues} and…

Domain shift, the mismatch between training and testing data characteristics, causes significant degradation in the predictive performance in multi-source imaging scenarios. In medical imaging, the heterogeneity of population, scanners and…

Foundation models (FMs) have emerged as a transformative paradigm in medical image analysis, offering the potential to provide generalizable, task-agnostic solutions across a wide range of clinical tasks and imaging modalities. Their…

Widely adopted medical image segmentation methods, although efficient, are primarily deterministic and remain poorly amenable to natural language prompts. Thus, they lack the capability to estimate multiple proposals, human interaction, and…

Deep learning models trained on medical images from a source domain (e.g. imaging modality) often fail when deployed on images from a different target domain, despite imaging common anatomical structures. Deep unsupervised domain adaptation…

For medical image segmentation, imagine if a model was only trained using MR images in source domain, how about its performance to directly segment CT images in target domain? This setting, namely generalizable cross-modality segmentation,…

Machine learning techniques used in computer-aided medical image analysis usually suffer from the domain shift problem caused by different distributions between source/reference data and target data. As a promising solution, domain…