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Drug repurposing plays a critical role in accelerating treatment discovery, especially for complex and rare diseases. Biomedical knowledge graphs (KGs), which encode rich clinical associations, have been widely adopted to support this task.…

Computation and Language · Computer Science 2025-10-15 Chengrui Xiang , Tengfei Ma , Xiangzheng Fu , Yiping Liu , Bosheng Song , Xiangxiang Zeng

Large Language Models (LLMs) have shown remarkable progress in medical question answering (QA), yet their effectiveness remains predominantly limited to English due to imbalanced multilingual training data and scarce medical resources for…

Large language models (LLMs) acquire knowledge across diverse domains such as science, history, and geography encountered during generative pre-training. However, due to their stochasticity, it is difficult to predict what LLMs have…

Computation and Language · Computer Science 2026-01-27 Kartik Sharma , Yiqiao Jin , Rakshit Trivedi , Srijan Kumar

In today's rapidly evolving landscape of Artificial Intelligence, large language models (LLMs) have emerged as a vibrant research topic. LLMs find applications in various fields and contribute significantly. Despite their powerful language…

Computation and Language · Computer Science 2024-09-10 Tuan Bui , Oanh Tran , Phuong Nguyen , Bao Ho , Long Nguyen , Thang Bui , Tho Quan

Medical large vision-language Models (Med-LVLMs) have shown promise in clinical applications but suffer from factual inaccuracies and unreliable outputs, posing risks in real-world diagnostics. While RAG has emerged as a potential solution,…

Computation and Language · Computer Science 2026-05-05 Zhe Chen , Yusheng Liao , Zhiyuan Zhu , Haolin Li , Hongcheng Liu , Yanfeng Wang , Yu Wang

With the rapid development of precision medicine, a large amount of health data (such as electronic health records, gene sequencing, medical images, etc.) has been produced. It encourages more and more interest in data-driven insight…

Computation and Language · Computer Science 2019-12-10 Sendong Zhao , Fei Wang

Large language models (LLMs) have been extensively studied for their abilities to generate convincing natural language sequences, however their utility for quantitative information retrieval is less well understood. Here we explore the…

Retrieval-Augmented Generation (RAG) enhances Large Language Models (LLMs) by integrating them with an external knowledge base to improve the answer relevance and accuracy. In real-world scenarios, beyond pure text, a substantial amount of…

Computation and Language · Computer Science 2025-10-07 Jiaru Zou , Dongqi Fu , Sirui Chen , Xinrui He , Zihao Li , Yada Zhu , Jiawei Han , Jingrui He

Large Language Models (LLMs) have shown promising performance on diverse medical benchmarks, highlighting their potential in supporting real-world clinical tasks. Retrieval-Augmented Generation (RAG) has emerged as a key approach for…

Computation and Language · Computer Science 2025-09-30 Kaishuai Xu , Wenjun Hou , Yi Cheng , Wenjie Li

The causal relationships between biomarkers are essential for disease diagnosis and medical treatment planning. One notable application is Alzheimer's disease (AD) diagnosis, where certain biomarkers may influence the presence of others,…

Information Retrieval · Computer Science 2025-06-13 Xiaofan Zhou , Liangjie Huang , Pinyang Cheng , Wenpen Yin , Rui Zhang , Wenrui Hao , Lu Cheng

Large language models (LLM) hold significant potential for applications in biomedicine, but they struggle with hallucinations and outdated knowledge. While retrieval-augmented generation (RAG) is generally employed to address these issues,…

Computation and Language · Computer Science 2025-09-23 Jiwoong Sohn , Yein Park , Chanwoong Yoon , Sihyeon Park , Hyeon Hwang , Mujeen Sung , Hyunjae Kim , Jaewoo Kang

Retrieval-Augmented Generation (RAG) enhances large language models (LLMs) by integrating external knowledge, where the LLM's ability to generate responses based on the combination of a given query and retrieved documents is crucial.…

Computation and Language · Computer Science 2025-08-01 Zhehao Tan , Yihan Jiao , Dan Yang , Lei Liu , Jie Feng , Duolin Sun , Yue Shen , Jian Wang , Peng Wei , Jinjie Gu

Answering complex real-world questions in the medical domain often requires accurate retrieval from medical Textual Knowledge Graphs (medical TKGs), as the relational path information from TKGs could enhance the inference ability of Large…

Computation and Language · Computer Science 2026-04-14 Jiatan Huang , Mingchen Li , Zonghai Yao , Dawei Li , Yuxin Zhang , Zhichao Yang , Yongkang Xiao , Feiyun Ouyang , Xiaohan Li , Shuo Han , Hong Yu

The increasing use of large language models (LLMs) in causal discovery as a substitute for human domain experts highlights the need for optimal model selection. This paper presents the first hallucination survey of popular LLMs for causal…

Computation and Language · Computer Science 2024-11-21 Grace Sng , Yanming Zhang , Klaus Mueller

Multimodal Entity Linking (MEL) is a fundamental task in data management that maps ambiguous mentions with diverse modalities to the multimodal entities in a knowledge base. However, most existing MEL approaches primarily focus on…

Computation and Language · Computer Science 2026-04-23 Mo Zhou , Jianwei Wang , Kai Wang , Helen Paik , Ying Zhang , Wenjie Zhang

Retrieval-augmented generation (RAG) enables large language models (LLMs) to dynamically access external information, which is powerful for answering questions over previously unseen documents. Nonetheless, they struggle with high-level…

Artificial Intelligence · Computer Science 2026-04-21 Chi-Hsiang Hsiao , Yi-Cheng Wang , Tzung-Sheng Lin , Yi-Ren Yeh , Chu-Song Chen

Recent advances in large language models (LLMs) have shown great potential to accelerate drug discovery. However, the specialized nature of biochemical data often necessitates costly domain-specific fine-tuning, posing major challenges.…

Machine Learning · Computer Science 2025-11-17 Namkyeong Lee , Edward De Brouwer , Ehsan Hajiramezanali , Tommaso Biancalani , Chanyoung Park , Gabriele Scalia

Large Language Models (LLMs) have demonstrated significant potential in medical Question Answering (QA), yet they remain prone to hallucinations and ungrounded reasoning, limiting their reliability in high-stakes clinical scenarios. While…

Information Retrieval · Computer Science 2026-01-09 Jessica Ryan , Alexander I. Gumilang , Robert Wiliam , Derwin Suhartono

Biomedical question answering (QA) requires accurate interpretation of complex medical knowledge. Large language models (LLMs) have shown promising capabilities in this domain, with retrieval-augmented generation (RAG) systems enhancing…

Computation and Language · Computer Science 2025-10-21 Yingpeng Ning , Yuanyuan Sun , Ling Luo , Yanhua Wang , Yuchen Pan , Hongfei Lin

Large language models (LLMs) incorporated with Retrieval-Augmented Generation (RAG) have demonstrated powerful capabilities in generating counterspeech against misinformation. However, current studies rely on limited evidence and offer less…

Computation and Language · Computer Science 2025-09-16 Anirban Saha Anik , Xiaoying Song , Elliott Wang , Bryan Wang , Bengisu Yarimbas , Lingzi Hong