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Large language models (LLMs) often need to incorporate external knowledge to solve theme-specific problems. Retrieval-augmented generation (RAG) has shown its high promise, empowering LLMs to generate more qualified responses with retrieved…

Machine Learning · Computer Science 2025-08-05 Jimeng Shi , Sizhe Zhou , Bowen Jin , Wei Hu , Runchu Tian , Shaowen Wang , Giri Narasimhan , Jiawei Han

Understanding mechanistic relationships among genes and their impacts on biological pathways is essential for elucidating disease mechanisms and advancing precision medicine. Despite the availability of extensive molecular interaction and…

Molecular Networks · Quantitative Biology 2026-03-24 Fujian Jia , Jiwen Gu , Cheng Lu , Dezhi Zhao , Mengjiang Huang , Yuanzhi Lu , Xin Liu , Kang Liu

Large Language Models (LLMs) excel in data synthesis but can be inaccurate in domain-specific tasks, which retrieval-augmented generation (RAG) systems address by leveraging user-provided data. However, RAGs require optimization in both…

Computation and Language · Computer Science 2024-11-05 Kazi Ahmed Asif Fuad , Lizhong Chen

In this paper, we present a new approach to improving the relevance and reliability of medical IR, which builds upon the concept of Level of Evidence (LoE). LoE framework categorizes medical publications into 7 distinct levels based on the…

Information Retrieval · Computer Science 2025-05-20 Sameh Frihat , Norbert Fuhr

This paper introduces a system that integrates large language models (LLMs) into the clinical trial retrieval process, enhancing the effectiveness of matching patients with eligible trials while maintaining information privacy and allowing…

Information Retrieval · Computer Science 2024-11-01 Georgios Peikos , Pranav Kasela , Gabriella Pasi

Retrieval-Augmented Generation (RAG) has recently demonstrated the performance of Large Language Models (LLMs) in the knowledge-intensive tasks such as Question-Answering (QA). RAG expands the query context by incorporating external…

Machine Learning · Computer Science 2024-06-18 Zijian Hei , Weiling Liu , Wenjie Ou , Juyi Qiao , Junming Jiao , Guowen Song , Ting Tian , Yi Lin

Large language models (LLMs) have demonstrated remarkable capabilities across various domains, although their susceptibility to hallucination poses significant challenges for their deployment in critical areas such as healthcare. To address…

Computation and Language · Computer Science 2024-05-13 Mengjia Niu , Hao Li , Jie Shi , Hamed Haddadi , Fan Mo

Large language models (LLMs) are widely used in retrieval-augmented generation (RAG) to incorporate external knowledge at inference time. However, when retrieved contexts are noisy, incomplete, or heterogeneous, a single generation process…

Computation and Language · Computer Science 2026-04-22 Xingchen Xiao , Heyan Huang , Runheng Liu , Jincheng Xie

Large-scale language models (LLMs) have achieved remarkable success across various language tasks but suffer from hallucinations and temporal misalignment. To mitigate these shortcomings, Retrieval-augmented generation (RAG) has been…

Computation and Language · Computer Science 2024-04-30 Zhongzhen Huang , Kui Xue , Yongqi Fan , Linjie Mu , Ruoyu Liu , Tong Ruan , Shaoting Zhang , Xiaofan Zhang

Teaching large language models (LLMs) to use tools is crucial for improving their problem-solving abilities and expanding their applications. However, effectively using tools is challenging because it requires a deep understanding of tool…

Machine Learning · Computer Science 2025-06-27 Jingwei Wang , Zai Zhang , Hao Qian , Chunjing Gan , Binbin Hu , Ziqi Liu , Zhiqiang Zhang , Jun Zhou , Bin Shi , Bo Dong

Retrieval-augmented generation (RAG) is a paradigm that augments large language models (LLMs) with external knowledge to tackle knowledge-intensive question answering. While several benchmarks evaluate Multimodal LLMs (MLLMs) under…

Computation and Language · Computer Science 2025-08-18 Yin Wu , Quanyu Long , Jing Li , Jianfei Yu , Wenya Wang

Recent advances in Large Language Models (LLMs) have positioned them as a prominent solution for Natural Language Processing tasks. Notably, they can approach these problems in a zero or few-shot manner, thereby eliminating the need for…

Machine Learning · Computer Science 2025-05-07 Gerard Pons , Besim Bilalli , Anna Queralt

Large language models (LLMs) have emerged as powerful tools for knowledge-intensive tasks across domains. In materials science, to find novel materials for various energy efficient devices for various real-world applications, requires…

Materials Science · Physics 2025-08-12 Agada Joseph Oche , Arpan Biswas

With the rise of knowledge graph based retrieval-augmented generation (RAG) techniques such as GraphRAG and Pike-RAG, the role of knowledge graphs in enhancing the reasoning capabilities of large language models (LLMs) has become…

Information Retrieval · Computer Science 2025-04-15 Hairong Zhang , Jiaheng Si , Guohang Yan , Boyuan Qi , Pinlong Cai , Song Mao , Ding Wang , Botian Shi

Causal structure discovery from observations can be improved by integrating background knowledge provided by an expert to reduce the hypothesis space. Recently, Large Language Models (LLMs) have begun to be considered as sources of prior…

Machine Learning · Computer Science 2024-05-24 Victor-Alexandru Darvariu , Stephen Hailes , Mirco Musolesi

Retrieval-Augmented Generation (RAG) improves Large Language Models (LLMs) by retrieving supporting documents into the prompt, but existing methods do not explicitly target queries that require fetching multiple documents with substantially…

Large Language Models (LLMs) often generate inaccurate responses (hallucinations) when faced with questions beyond their knowledge scope. Retrieval-Augmented Generation (RAG) addresses this by leveraging external knowledge, but a critical…

Information Retrieval · Computer Science 2025-09-10 Haoxiang Jin , Ronghan Li , Zixiang Lu , Qiguang Miao

Generating multiple-choice questions (MCQs) with difficulty estimation remains challenging in automated MCQ-generation systems used in adaptive, AI-assisted education. This study proposes a novel methodology for generating MCQs with…

Computation and Language · Computer Science 2026-04-14 Mehmet Can Şakiroğlu , H. Altay Güvenir , Kamer Kaya

Harnessing the robust capabilities of Large Language Models (LLMs) for narrative generation, logical reasoning, and common-sense knowledge integration, this study delves into utilizing LLMs to enhance automated radiology report generation…

Computer Vision and Pattern Recognition · Computer Science 2024-10-08 Yingshu Li , Zhanyu Wang , Yunyi Liu , Lei Wang , Lingqiao Liu , Luping Zhou

A common way to extend the memory of large language models (LLMs) is by retrieval augmented generation (RAG), which inserts text retrieved from a larger memory into an LLM's context window. However, the context window is typically limited…

Computation and Language · Computer Science 2025-02-14 Marc Pickett , Jeremy Hartman , Ayan Kumar Bhowmick , Raquib-ul Alam , Aditya Vempaty
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